Výsledky vyhledávání - "Osteoblasts/metabolism"

Physiological Mineralization during In Vitro Osteogenesis in a Biomimetic Spheroid Culture Model

Autor: Maximilian Koblenzer, Marek Weiler, Athanassios Fragoulis, Stephan Rütten, Thomas Pufe, Holger Jahr

Publikováno v: Cells; Volume 11; Issue 17; Pages: 2702
Cells : open access journal 11(17), 2702 (2022). doi:10.3390/cells11172702 special issue: "Topical Collection "Advances in 3D Cell Culture" / Editor: Dr. Julia Schueler, Guest Editor"
Cells, 11(17):2702. Multidisciplinary Digital Publishing Institute (MDPI)

Cells : open access journal 11(17), 2702 (2022). doi:10.3390/cells11172702 special issue: "Topical Collection "Advances in 3D Cell Culture" / Editor: Dr. Julia Schueler, Guest Editor"
Published by MDPI, Basel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b74731a5a1ef8d7d71dbabcee427674

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TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases

Autor: Rachel Deplus, Martine Duterque-Coquillaud, Anne Flourens, Edith Bonnelye, Nathalie Vanpouille, Tian V. Tian, Philippe Clézardin, Anais Fradet, Carine Delliaux, Xavier Leroy, Yvan de Launoit, Mathilde Bouchet, Arnauld Villers

Publikováno v: Cancer Letters
Cancer Letters, Elsevier, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩
Cancer Letters, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩

International audience; Abstract : Prostate cancers have a strong propensity to metastasize to bone and promote osteoblastic lesions. TMPRSS2:ERG is the most frequent gene rearrangement identified in prostate cancer, but whether it is involved in pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2efdc0696479c6db9b921256206c223
https://doi.org/10.1016/j.canlet.2018.08.027

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A soluble activin type IIA receptor mitigates the loss of femoral neck bone strength and cancellous bone mass in a mouse model of disuse osteopenia

Autor: Jesper Skovhus Thomsen, Marco Eijken, Andreas Lodberg, Bram C. J. van der Eerden, Mette Wendelboe Okkels, Annemarie Brüel

Publikováno v: Bone, 110, 326-334. Elsevier Inc.
Lodberg, A, Eijken, M, van der Eerden, B C J, Okkels, M W, Thomsen, J S & Brüel, A 2018, ' A soluble activin type IIA receptor mitigates the loss of femoral neck bone strength and cancellous bone mass in a mouse model of disuse osteopenia ', Bone, vol. 110, pp. 326-334 . https://doi.org/10.1016/j.bone.2018.02.026

Disuse causes a rapid and substantial bone loss distinct in its pathophysiology from the bone loss associated with cancers, age, and menopause. While inhibitors of the activin-receptor signaling pathway (IASPs) have been shown to prevent ovariectomy-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f433b191154dbdfc94b8f2ac409a97ca
https://doi.org/10.1016/j.bone.2018.02.026

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Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2

Autor: Christopher R. Paradise, Joanna S. Price, Gabriel L. Galea, Andre J. van Wijnen, Emily T. Camilleri, Gary S. Stein, Lance E. Lanyon, Amel Dudakovic, Lee B Meakin, Hanna Taipaleenmäki

Publikováno v: Gene: X
Galea, G L, Paradise, C R, Meakin, L B, Camilleri, E T, Taipaleenmaki, H, Stein, G S, Lanyon, L E, Price, J S, van Wijnen, A J & Dudakovic, A 2020, ' Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2 ', Gene, vol. 763S, 100027, pp. 100027 . https://doi.org/10.1016/j.gene.2020.100027
Gene: X, Vol 5, Iss, Pp 100027-(2020)

Mechanical loading-related strains trigger bone formation by osteoblasts while suppressing resorption by osteoclasts, uncoupling the processes of formation and resorption. Osteocytes may orchestrate this process in part by secreting sclerostin (SOST)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25bf36d9a55ee08ac308c9e986aaf2e
http://europepmc.org/articles/PMC7285908

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Do RANKL inhibitors (denosumab) affect inflammation and immunity?

Autor: Serge Ferrari, Sylvie Ferrari-Lacraz

Publikováno v: Osteoporosis International, Vol. 22, No 2 (2011) pp. 435-46

Receptor activator of nuclear factor kappa B ligand (RANKL) and its natural antagonist, osteoprotegerin (OPG), are, respectively, an indispensable factor and a potent inhibitor for osteoclast differentiation, activity, and survival. The development o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93590c4b9c41bd23603b324ca0f98b02
http://doc.rero.ch/record/317114/files/198_2010_Article_1326.pdf

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The purinergic P2X7 ion channel receptor — a ‘repair’ receptor in bone

Autor: Niklas Rye Jørgensen

Publikováno v: Jørgensen, N R 2018, ' The purinergic P2X7 ion channel receptor — a ‘repair’ receptor in bone ', Current Opinion in Immunology, vol. 52, pp. 32-38 . https://doi.org/10.1016/j.coi.2018.03.016

A strong skeleton relies on adaptation to varying physical demands and on maintenance of the bone tissue in order to avoid accumulation of micro-damage. In bone, the purinergic P2X7 ion channel receptor is expressed on both cells of the stromal linea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0cbf6c9dac758442404957701789c7
https://portal.findresearcher.sdu.dk/da/publications/38f359d8-2779-45ae-8693-3ba4d1277729

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Interleukin-17A Inhibition Diminishes Inflammation and New Bone Formation in Experimental Spondyloarthritis

Autor: Lukas Roth, Dominique Baeten, Peter Ingold, Sabina Pfister, Leonie M. van Duivenvoorde, Melissa N van Tok, Ina Kramer, Marleen G H van de Sande, Frank Kolbinger, Joel D. Taurog, Iris C Blijdorp

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.), 71(4), 612-625. John Wiley and Sons Ltd

Objective It remains unclear if and how inflammation and new bone formation in spondyloarthritis (SpA) are coupled. We undertook this study to assess the hypothesis that interleukin-17A (IL-17A) is a pivotal driver of both processes. Methods The effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde7bc3dbdca58d472f85325f9e2e9aa
https://pubmed.ncbi.nlm.nih.gov/30663867

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Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice

Autor: Anne Wilson, He Fu, Mariano Schiffrin, Carine Winkler, Meriem Koufany, Jean-Yves Jouzeau, Nicolas Bonnet, Federica Gilardi, François Renevey, Sanjiv A. Luther, David Moulin, Béatrice Desvergne

Publikováno v: Frontiers in Immunology, Vol. 9, No Art. 2573 (2018)
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2018, 9, pp.2573. ⟨10.3389/fimmu.2018.02573⟩
Frontiers in immunology, vol. 9, pp. 2573

Adult hematopoiesis takes place in the perivascular zone of the bone cavity, where endothelial cells, mesenchymal stromal/stem cells and their derivatives such as osteoblasts are key components of bone marrow (BM) niches. Defining the contribution of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf48045a873f472936d5f9184e31b5d0
https://archive-ouverte.unige.ch/unige:112931

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