RSPO3 is important for trabecular bone and fracture risk in mice and humans

Autor: Karin H Nilsson, Pedro P. C. Souza, Linda Engstrom Ruud, Charlotte Ejersted, Maha El Shahawy, Maria Nethander, Terho Lehtimäki, Thomas Levin Andersen, Jonathan H Tobias, Ulf H. Lerner, Antti Koskela, Sirui Zhou, Petra Henning, Juha Tuukkanen, Mattias Lorentzon, Karin Gustafsson, Sofia Movérare-Skrtic, J. Brent Richards, Claes Ohlsson, Jianyao Wu, Jan Tuckermann

Publikováno v: Nilsson, K H, Henning, P, Shahawy, M E, Nethander, M, Andersen, T L, Ejersted, C, Wu, J, Gustafsson, K L, Koskela, A, Tuukkanen, J, Souza, P P C, Tuckermann, J, Lorentzon, M, Ruud, L E, Lehtimäki, T, Tobias, J H, Zhou, S, Lerner, U H, Richards, J B, Movérare-Skrtic, S & Ohlsson, C 2021, ' RSPO3 is important for trabecular bone and fracture risk in mice and humans ', Nature Communications, vol. 12, 4923 . https://doi.org/10.1038/s41467-021-25124-2
Nilsson, K H, Henning, P, Shahawy, M E, Nethander, M, Andersen, T L, Ejersted, C, Wu, J, Gustafsson, K L, Koskela, A, Tuukkanen, J, Souza, P P C, Tuckermann, J, Lorentzon, M, Engstrom Ruud, L, Lehtimaki, T, Tobias, J H, Zhou, S, Lerner, U H, Richards, J B, Moverare-Skrtic, S & Ohlsson, C 2021, ' RSPO3 is important for trabecular bone and fracture risk in mice and humans ', Nature Communications, vol. 12, no. 1, 4923 . https://doi.org/10.1038/s41467-021-25124-2
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

With increasing age of the population, countries across the globe are facing a substantial increase in osteoporotic fractures. Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557d192dd887d01d6cc7db570daad747
https://findresearcher.sdu.dk:8443/ws/files/190718747/s41467_021_25124_2.pdf

Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway

Autor: Moustapha Kassem, Abdullah M. Alzahrani, Basem M. Abdallah

Publikováno v: Abdallah, B, Alzahrani, A M & Kassem, M 2018, ' Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway ', Bone, vol. 110, pp. 221-229 . https://doi.org/10.1016/j.bone.2018.02.018

Secreted Clusterin (sCLU, also known as Apolipoprotein J) is an anti-apoptotic glycoprotein involved in the regulation of cell proliferation, lipid transport, extracellular tissue remodeling and apoptosis. sCLU is expressed and secreted by mouse bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87a65599f7d54cacaef9ad69e0e2ae0
https://doi.org/10.1016/j.bone.2018.02.018

A Growth Factor-Free Co-Culture System of Osteoblasts and Peripheral Blood Mononuclear Cells for the Evaluation of the Osteogenesis Potential of Melt-Electrowritten Polycaprolactone Scaffolds

Publikováno v: International Journal of Molecular Sciences. 20(5)

Scaffolds made of biodegradable biomaterials are widely used to guide bone regeneration. Commonly, in vitro assessment of scaffolds' osteogenesis potential has been performed predominantly in monoculture settings. Hence, this study evaluated the pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od________83::11ad745ada6538f45937cd9f4d94708f
https://cris.maastrichtuniversity.nl/en/publications/49108e6f-038a-401a-9e98-e3e967ff061b

Co-Culture with Human Osteoblasts and Exposure to Extremely Low Frequency Pulsed Electromagnetic Fields Improve Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells

Autor: Sabrina, Ehnert, Martijn, van Griensven, Marina, Unger, Hanna, Scheffler, Karsten, Falldorf, Anne-Kristin, Fentz, Claudine, Seeliger, Steffen, Schröter, Andreas K, Nussler, Elizabeth R, Balmayor

Publikováno v: International journal of molecular sciences, 19(4):994. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 19, Iss 4, p 994 (2018)
International Journal of Molecular Sciences

Human adipose-derived mesenchymal stem cells (Ad-MSCs) have been proposed as suitable option for cell-based therapies to support bone regeneration. In the bone environment, Ad-MSCs will receive stimuli from resident cells that may favor their osteoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a1b137b9432350b1f3c085c494a7a16e
https://cris.maastrichtuniversity.nl/en/publications/ff766cf4-24dd-48f6-8163-3b923ce729df

CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling

Autor: Abdallah, Basem M., Figeac, Florence, Larsen, Kenneth H., Ditzel, Nicholas, Keshari, Pankaj, Isa, Adiba, Jafari, Abbas, Andersen, Thomas L., Delaisse, Jean Marie, Goshima, Yoshio, Ohshima, Toshio, Kassem, Moustapha

Publikováno v: Abdallah, B M, Figeac, F, Larsen, K H, Ditzel, N, Keshari, P, Isa, A, Jafari, A, Andersen, T L, Delaisse, J M, Goshima, Y, Ohshima, T & Kassem, M 2017, ' CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling ', Journal of Bone and Mineral Research, vol. 32, no. 5, pp. 913-926 . https://doi.org/10.1002/jbmr.3069

We identified the neuroprotein collapsing response mediator protein-4 (CRMP4) as a noncanonical osteogenic factor that regulates the differentiation of mouse bone marrow skeletal stem cells (bone marrow stromal stem cells [mBMSCs]) into osteoblastic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3062::f873d1ad5ac71bed7801e385be0bbdd6
https://portal.findresearcher.sdu.dk/da/publications/7d99d343-4853-4a63-a7b2-9ec53e370acf