Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ostap Kukhar"'
Autor:
Grant A. Challen, Paul Gontarz, Katherine Y. King, Won Kyun Koh, Hamza Celik, Emily Haussler, Jiameng Sun, Cates Mallaney, Ostap Kukhar, Elizabeth L. Ostrander, Christine R. Zhang
Clonal hematopoiesis (CH) refers to the age-related expansion of specific clones in the blood system, and manifests from somatic mutations acquired in hematopoietic stem cells (HSCs). Most CH variants occur in the gene DNMT3A, but while DNMT3A-mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b62818a0b0bfebc33d5d27553b7205
https://doi.org/10.1158/2643-3230.c.6550686.v1
https://doi.org/10.1158/2643-3230.c.6550686.v1
Autor:
Grant A. Challen, Paul Gontarz, Katherine Y. King, Won Kyun Koh, Hamza Celik, Emily Haussler, Jiameng Sun, Cates Mallaney, Ostap Kukhar, Elizabeth L. Ostrander, Christine R. Zhang
Supplementary Figure from Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616d2d6c65b956e5273592cf8e0eaa10
https://doi.org/10.1158/2643-3230.22544559.v1
https://doi.org/10.1158/2643-3230.22544559.v1
Autor:
Grant A. Challen, Stephen T. Oh, Holly K. Koblish, Matthew C. Stubbs, Terrence N. Wong, Jared S. Fowles, Daniel A.C. Fisher, Tiandao Li, Maggie Allen, Ostap Kukhar, Hassan Bjeije, Won Kyun Koh, Nancy Issa, Wentao Han, Christine R. Zhang, Ethan Krug, Hamza Celik
Myeloproliferative neoplasms (MPN) are chronic blood diseases with significant morbidity and mortality. Although sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a significant prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a567f6f5f98a0e2722cba1117219dcd
https://doi.org/10.1158/2159-8290.c.6549361.v1
https://doi.org/10.1158/2159-8290.c.6549361.v1
Autor:
Grant A. Challen, Stephen T. Oh, Holly K. Koblish, Matthew C. Stubbs, Terrence N. Wong, Jared S. Fowles, Daniel A.C. Fisher, Tiandao Li, Maggie Allen, Ostap Kukhar, Hassan Bjeije, Won Kyun Koh, Nancy Issa, Wentao Han, Christine R. Zhang, Ethan Krug, Hamza Celik
Supplementary Figures 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86778ff5c2d7a876a216678ab35f0a37
https://doi.org/10.1158/2159-8290.22540360
https://doi.org/10.1158/2159-8290.22540360
Autor:
Grant A. Challen, Stephen T. Oh, Holly K. Koblish, Matthew C. Stubbs, Terrence N. Wong, Jared S. Fowles, Daniel A.C. Fisher, Tiandao Li, Maggie Allen, Ostap Kukhar, Hassan Bjeije, Won Kyun Koh, Nancy Issa, Wentao Han, Christine R. Zhang, Ethan Krug, Hamza Celik
Hematological comparison of MF patients versus PDXs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ff66c0f13b2518d81ffaaab1ec8881
https://doi.org/10.1158/2159-8290.22540357
https://doi.org/10.1158/2159-8290.22540357
Autor:
Grant A. Challen, Stephen T. Oh, Holly K. Koblish, Matthew C. Stubbs, Terrence N. Wong, Jared S. Fowles, Daniel A.C. Fisher, Tiandao Li, Maggie Allen, Ostap Kukhar, Hassan Bjeije, Won Kyun Koh, Nancy Issa, Wentao Han, Christine R. Zhang, Ethan Krug, Hamza Celik
Exome sequencing results.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fee595b4886906d48090b82109c6e2
https://doi.org/10.1158/2159-8290.22540354
https://doi.org/10.1158/2159-8290.22540354
Autor:
Christine R. Zhang, Elizabeth L. Ostrander, Ostap Kukhar, Cates Mallaney, Jiameng Sun, Emily Haussler, Hamza Celik, Won Kyun Koh, Katherine Y. King, Paul Gontarz, Grant A. Challen
Publikováno v:
Blood Cancer Discov
Clonal hematopoiesis (CH) refers to the age-related expansion of specific clones in the blood system, and manifests from somatic mutations acquired in hematopoietic stem cells (HSCs). Most CH variants occur in the gene DNMT3A, but while DNMT3A-mutant
Autor:
Christine R. Zhang, Elizabeth Ostrander, Won Kyun Koh, Ostap kukhar, Hamza Celik, Jeffrey Magee, Grant Challen
Publikováno v:
Cancer Research. 82:LB555-LB555
Clonal hematopoiesis (CH), the age-related expansion of specific clones in the blood system has been considered as a pre-malignant condition of blood cancers. Approximately 50% of CH manifests from DNMT3A mutations acquired in the hematopoietic stem
Autor:
Hamza Celik, Stephen T. Oh, Terrence N. Wong, Ostap Kukhar, Wentao Han, Matthew C. Stubbs, Grant A. Challen, Maggie J. Allen, Nancy Issa, Daniel A.C. Fisher, Won Kyun Koh, Holly Koblish, Ethan Krug, Jared S. Fowles, Hassan Bjeije, Tiandao Li, Christine R. Zhang
Publikováno v:
Cancer Discov
Myeloproliferative neoplasms (MPN) are chronic blood diseases with significant morbidity and mortality. Although sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a significant prop
Autor:
Hamza Celik, Ostap Kukhar, Jake Fairchild, Christine R. Zhang, Grant A. Challen, Won Kyun Koh, Paul Gontarz, Jacob Tao
Publikováno v:
Blood. 138:24-24
The balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) is strictly regulated to sustain blood production throughout adult life. De novo DNA methyltransferase 3-alpha (DNMT3A) is one of the major epigenetic regulators