Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Osric A. Forrest"'
Autor:
Camilla Margaroli, Diego Moncada-Giraldo, Dalia Arafat Gulick, Brian Dobosh, Vincent D. Giacalone, Osric A. Forrest, Fangxu Sun, Chunhui Gu, Amit Gaggar, Haydn Kissick, Ronghu Wu, Greg Gibson, Rabindra Tirouvanziam
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100239- (2021)
Summary: Neutrophils are often considered terminally differentiated and poised for bacterial killing. In chronic diseases such as cystic fibrosis (CF), an unexplained paradox pits massive neutrophil presence against prolonged bacterial infections. He
Externí odkaz:
https://doaj.org/article/330b3a1590594f2eba3bc5803c699101
Autor:
Osric A Forrest, Brian Dobosh, Sarah A Ingersoll, Sanjana Rao, Alexander Rojas, Julie Laval, Jessica A Alvarez, Milton R Brown, Vin Tangpricha, Rabindra Tirouvanziam
Publikováno v:
Journal of leukocyte biologyREFERENCES. 112(4)
Cystic fibrosis (CF) airways feature high extracellular levels of the IL-1 family of proinflammatory mediators. These mediators are cleavage products of caspase-1, the final protease in the inflammasome cascade. Due to the proven chronic presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737d34ac5d1ac81a8776325ee67053d4
https://pubmed.ncbi.nlm.nih.gov/35172381
https://pubmed.ncbi.nlm.nih.gov/35172381
Autor:
Limin Peng, Yael Gernez, Daniel M. Chopyk, Milton R. Brown, Rabindra Tirouvanziam, Carol Conrad, Osric A. Forrest, Vin Tangpricha, Richard B. Moss
Publikováno v:
Journal of Cystic Fibrosis. 18:64-70
Background Resistin is an immunometabolic mediator that is elevated in several inflammatory disorders. A ligand for Toll-like receptor 4, resistin modulates the recruitment and activation of myeloid cells, notably neutrophils. Neutrophils are major d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d1f29cc5d72ac62317d9d42affbac8
https://doi.org/10.1016/j.jcf.2018.05.018
https://doi.org/10.1016/j.jcf.2018.05.018
Autor:
Rabindra Tirouvanziam, Liliana Viera, Xin Xu, Osric A. Forrest, Joscelyn C. Mejías, Jindong Li, Camilla Margaroli, David A Frey Rubio, Krishnendu Roy, Amit Gaggar
Pulmonary drug delivery presents a unique opportunity to target lower airway inflammation, which is often characterized by the massive recruitment of neutrophils from blood. However, specific therapies are lacking modulation of airway neutrophil func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e90906be0ec41b7bbf90be3d8d435f
https://europepmc.org/articles/PMC6962027/
https://europepmc.org/articles/PMC6962027/
Autor:
Camilla Margaroli, Diego Moncada Giraldo, Dalia Arafat-Gulick, Brian Dobosh, Vincent Giacalone, Haydn Kissick, Osric A Forrest, Chunhui Gu, Gregory Gibson, Rabindra M Tirouvanziam
Publikováno v:
The Journal of Immunology. 204:148.39-148.39
Rationale Neutrophils are often considered the first line of defense against bacterial infections. In cystic fibrosis (CF), massive neutrophil presence is concomitant with phenotypical changes and prolonged bacterial infections. Here, we sought to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c70b1279dec182a64bc4628622ec5670
https://doi.org/10.4049/jimmunol.204.supp.148.39
https://doi.org/10.4049/jimmunol.204.supp.148.39
Autor:
Julie Laval, Marcela K. Preininger, Ruxana T. Sadikot, Osric A. Forrest, Vin Tangpricha, Joanna B. Goldberg, Frances Eun-Hyung Lee, B. Bedi, Sarah A. Ingersoll, Amit Gaggar, Rabindra Tirouvanziam, Dominique H. Limoli, Milton R. Brown
Publikováno v:
J Leukoc Biol
Recruitment of neutrophils to the airways, and their pathological conditioning therein, drive tissue damage and coincide with the loss of lung function in patients with cystic fibrosis (CF). So far, these key processes have not been adequately recapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d66e6e6b23cb1688186c93050b330f
https://europepmc.org/articles/PMC6956843/
https://europepmc.org/articles/PMC6956843/
Autor:
Zachary C Hand, John P Brandt, Kristian M. Hargadon, Johnathan D Bishop, Osric A. Forrest, Yonathan Ararso
Publikováno v:
Immunology & Cell Biology. 94:24-38
Dendritic cells (DCs) are key regulators of host immunity that are capable of inducing either immune tolerance or activation. In addition to their well-characterized role in shaping immune responses to foreign pathogens, DCs are also known to be crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a9a24afc701ed9e2869daab5d0abcf
https://doi.org/10.1038/icb.2015.58
https://doi.org/10.1038/icb.2015.58
Autor:
Greg Gibson, Vin Tangpricha, Marcela K. Preininger, Osric A. Forrest, Sarah A. Ingersoll, Julie Laval, Dalia Arafat, Rabindra Tirouvanziam, Milton R. Brown
Publikováno v:
The Journal of Immunology. 194:5520-5528
Bacteria colonize cystic fibrosis (CF) airways, and although T cells with appropriate Ag specificity are present in draining lymph nodes, they are conspicuously absent from the lumen. To account for this absence, we hypothesized that polymorphonuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd8f8d588a49b887f198c85626e7a90
https://doi.org/10.4049/jimmunol.1500312
https://doi.org/10.4049/jimmunol.1500312
Publikováno v:
American Journal of Immunology. 8:179-190
Dendritic cells function as potent regulators of both innate and adaptive immunity to tumors and the regulatory activities of these cells are tightly linked to their maturation and activation status. Despite the critical role played by dendritic cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2761a444544cb7977e01723d1568a71
https://doi.org/10.3844/ajisp.2012.179.190
https://doi.org/10.3844/ajisp.2012.179.190
Publikováno v:
Cellular immunology. 272(2)
Dendritic cells play critical roles in both innate and adaptive immunity, and their numerous functions are tightly linked to their maturation and activation status. Here, we characterize the murine dendritic cell line DC2.4 as a model for studying de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390e8f1f3fdca886900d78da6d1ef6c6
https://pubmed.ncbi.nlm.nih.gov/22051048
https://pubmed.ncbi.nlm.nih.gov/22051048