Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy.

Autor: Reinstein ZZ; Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Center for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Zhang Y; Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Ospina OE; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Nichols MD; Department of Tumor Metastasis and Microenvironment, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Chu VA; Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Pulido AM; Department of Tumor Metastasis and Microenvironment, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Prieto K; Department of Tumor Metastasis and Microenvironment, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Nguyen JV; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Yin R; University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland.; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland., Moran Segura C; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Usman A; Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Sell B; Department of Tumor Metastasis and Microenvironment, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Ng S; Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Center for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., de la Iglesia JV; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Chandra S; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Sosman JA; Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Cho RJ; Department of Dermatology, University of California, San Francisco, San Francisco, California., Cheng JB; Department of Dermatology, University of California, San Francisco, San Francisco, California.; Department of Dermatology, Veterans Affairs Medical Center, San Francisco, California., Ivanova E; Department of Pathology, New York University School of Medicine, New York, New York., Koralov SB; Department of Pathology, New York University School of Medicine, New York, New York.; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University, Grossman School of Medicine, New York, New York., Slebos RJC; Department of Head and Neck Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Chung CH; Department of Head and Neck Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Khushalani NI; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.; Donald A. Adam Melanoma and Skin Cancer Center of Excellence, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Messina JL; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.; Donald A. Adam Melanoma and Skin Cancer Center of Excellence, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Sarnaik AA; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.; Donald A. Adam Melanoma and Skin Cancer Center of Excellence, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Zager JS; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.; Donald A. Adam Melanoma and Skin Cancer Center of Excellence, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Sondak VK; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.; Donald A. Adam Melanoma and Skin Cancer Center of Excellence, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Vaske C; Clear Labs, Santa Cruz, California., Kim S; Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Brohl AS; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.; Donald A. Adam Melanoma and Skin Cancer Center of Excellence, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Mi X; Department of Preventive Medicine-Biostatistics Quantitative Data Sciences Core, Northwestern University, Chicago, Illinois., Pierce BG; University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland.; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland.; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland., Wang X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Fridley BL; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Tsai KY; Department of Tumor Metastasis and Microenvironment, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.; Donald A. Adam Melanoma and Skin Cancer Center of Excellence, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Choi J; Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Center for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Center for Synthetic Biology, Northwestern University, Evanston, Illinois.

Publikováno v: Cancer discovery [Cancer Discov] 2024 Sep 04; Vol. 14 (9), pp. 1631-1652.

Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease.

Autor: Alhaddad H; Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA., Ospina OE; Department of Biostatistics and Bioinformatics at the Moffitt Cancer Center, Tampa, FL, USA., Khaled ML; Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Ren Y; Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA., Vallebuona E; Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA; Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL, USA., Boozo MB; Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA., Forsyth PA; Department of Tumor Biology, Moffitt Cancer Center, Tampa, FL, USA; Department of NeuroOncology, Moffitt Cancer Center, Tampa, FL, USA., Pina Y; Department of NeuroOncology, Moffitt Cancer Center, Tampa, FL, USA., Macaulay R; Department of Pathology, Moffitt Cancer Center, Tampa, FL, USA., Law V; Department of Tumor Biology, Moffitt Cancer Center, Tampa, FL, USA; Department of NeuroOncology, Moffitt Cancer Center, Tampa, FL, USA., Tsai KY; Department of Pathology, Moffitt Cancer Center, Tampa, FL, USA., Cress WD; Department of Molecular Oncology at the Moffitt Cancer Center, Tampa, FL, USA., Fridley B; Department of Biostatistics and Bioinformatics at the Moffitt Cancer Center, Tampa, FL, USA; Division of Health Services & Outcomes Research, Children's Mercy Hospital, Kansas City, MO 64108, USA. Electronic address: blfridley@cmh.edu., Smalley I; Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA; Department of Cutaneous Oncology at the Moffitt Cancer Center, Tampa, FL, USA. Electronic address: inna.smalley@moffitt.org.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Jun 18; Vol. 5 (6), pp. 101606. Date of Electronic Publication: 2024 Jun 11.

WITHDRAWN: Impact of spatial clustering of cytotoxic and tumor infiltrating lymphocytes on overall survival in women with high grade serous ovarian cancer.

Autor: Soupir AC, Townsend MK, Hathaway CA, Nguyen J, Moran Segura C, Saeed-Vafa D, Ospina OE, Peres LC, Conejo-Garcia JR, Terry KL, Tworoger SS, Fridley BL

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Feb 28. Date of Electronic Publication: 2024 Feb 28.

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease.

Autor: Khaled ML; The Department of Metabolism and Physiology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA.; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Egypt., Ren Y; The Department of Metabolism and Physiology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Kundalia R; The Department of Metabolism and Physiology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Alhaddad H; The Department of Metabolism and Physiology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Chen Z; Department of Biostatistics and Bioinformatics, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Wallace GC; Department of Hematology/Oncology, Georgia Cancer Center at Medical College of Georgia, Augusta, GA, USA., Evernden B; Department of Neuro Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Ospina OE; Department of Biostatistics and Bioinformatics, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Hall M; Department of Immunology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Liu M; The Proteomics and Metabolomics Core, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Darville LNF; The Proteomics and Metabolomics Core, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Izumi V; The Proteomics and Metabolomics Core, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Chen YA; Department of Biostatistics and Bioinformatics, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Pilon-Thomas S; Department of Immunology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Stewart PA; Department of Biostatistics and Bioinformatics, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Koomen JM; The Proteomics and Metabolomics Core, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA.; Department of Molecular Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Corallo SA; Department of Blood and Marrow Transplant and Cellular Immunotherapy, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Jain MD; Department of Blood and Marrow Transplant and Cellular Immunotherapy, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Robinson TJ; Therapeutic Radiology, Smilow Cancer Hospital at Yale New Haven, 35 Park Street, New Haven, CT, USA., Locke FL; Department of Blood and Marrow Transplant and Cellular Immunotherapy, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Forsyth PA; Department of Neuro Oncology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA.; The Department of Tumor Biology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Smalley I; The Department of Metabolism and Physiology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 18. Date of Electronic Publication: 2023 Dec 18.

spatialTIME and iTIME: R package and Shiny application for visualization and analysis of immunofluorescence data.

Autor: Creed JH; Department of Biostatistics and Bioinformatics, Tampa, FL, USA., Wilson CM; Department of Biostatistics and Bioinformatics, Tampa, FL, USA., Soupir AC; Department of Biostatistics and Bioinformatics, Tampa, FL, USA.; Department of Tumor Biology, Tampa, FL, USA., Colin-Leitzinger CM; Department of Cancer Epidemiology, Tampa, FL, USA., Kimmel GJ; Department of Integrated Mathematical Oncology, Tampa, FL, USA., Ospina OE; Department of Biostatistics and Bioinformatics, Tampa, FL, USA., Chakiryan NH; Department of Genitourinary Oncology, Tampa, FL, USA., Markowitz J; Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA., Peres LC; Department of Cancer Epidemiology, Tampa, FL, USA., Coghill A; Department of Cancer Epidemiology, Tampa, FL, USA., Fridley BL; Department of Biostatistics and Bioinformatics, Tampa, FL, USA.

Publikováno v: Bioinformatics (Oxford, England) [Bioinformatics] 2021 Dec 07; Vol. 37 (23), pp. 4584-4586.