Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Osnat Bohana-Kashtan"'
Autor:
Bruno Bockorny, Jaime Feliu, Katrina S. Pedersen, Amnon Peled, Stephen M. Shaw, Osnat Bohana-Kashtan, Brian M. Wolpin, Marya F. Chaney, Abi Vainstein Haras, Ella Sorani, Daniel D. Von Hoff, Mariano Ponz-Sarvise, Manuel Hidalgo, Tzipora M. Lustig, Ravit Geva, David Gutierrez Abad, Valerya Semenisty, Robert A. Ramirez, Salomon M. Stemmer, Mitesh J. Borad, Erkut Borazanci, Andrés Muñoz, Shaul Kadosh, Teresa Macarulla, Talia Golan, Joon Oh Park
Publikováno v:
Nature Medicine. 26:878-885
Programmed cell death 1 (PD-1) inhibitors have limited effect in pancreatic ductal adenocarcinoma (PDAC), underscoring the need to co-target alternative pathways. CXC chemokine receptor 4 (CXCR4) blockade promotes T cell tumor infiltration and is syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::268e508d34a101dc8785f1599c78596a
https://doi.org/10.1038/s41591-020-0880-x
https://doi.org/10.1038/s41591-020-0880-x
Autor:
Osnat Bohana-Kashtan, Margaret M. Showel, Martin S. Tallman, Jessica K. Altman, Abi Vainstein-Haras, James M. Foran, Avichai Shimoni, Arnon Aharon, Michal Abraham, Yaron Pereg, Shaul Kadosh, Arnon Nagler, Ella Sorani, Yishai Ofran, Galia Oberkovitz, Naveen Pemmaraju, Amnon Peled, Ahmed AlRawi, Emil Samara, Geoffrey L. Uy, Tzipi Lustig, Michael Andreeff, Irit Glicko-Kabir, Stephen Shaw, Jorge E. Cortes, Carlos E. Bueso-Ramos, Adam Foley-Comer, Gautam Borthakur, John F. DiPersio, Jacob M. Rowe
Publikováno v:
CancerReferences. 127(8)
Background CXCR4 mediates the retention and survival of acute myelogenous leukemia blasts in bone marrow and contributes to their resistance to chemotherapy. The authors evaluated a combination of the high-affinity CXCR4 antagonist BL-8040 with high-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361f91de0dbad69405fb83eb9466f1d7
https://pubmed.ncbi.nlm.nih.gov/33270904
https://pubmed.ncbi.nlm.nih.gov/33270904
Publikováno v:
Cancer Research. 81:1320-1320
Mesenchymal stem cells (MSC) have been extensively investigated as cell carriers or cell therapies for treating a wide range of malignant and inflammatory diseases. In addition, recent studies show that MSCs' tropism to malignant and inflamed tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08168785ca7deb6da97d727fb386a7fa
https://doi.org/10.1158/1538-7445.am2021-1320
https://doi.org/10.1158/1538-7445.am2021-1320
Autor:
Jaime Feliu, D. Gutierrez Abad, Teresa Macarulla, Shaul Kadosh, Bruno Bockorny, Y. Gozlan, M. Ponz Sarvise, Ella Sorani, A.V. Vainstein, Amnon Peled, Osnat Bohana-Kashtan, Marya F. Chaney, Manuel Hidalgo, Valerya Semenisty, Erkut Borazanci, D. D. Von Hoff
Publikováno v:
Annals of Oncology. 30:xi33
Background Current treatment options for PDAC are limited. While PD-1/PD-L1 antagonists have shown promising results in other cancer types, this approach has been ineffective in PDAC. In Cohort 1 of the COMBAT study, the dual combination of BL-8040 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::685df07c3749de9fbe9684788557f7b4
https://doi.org/10.1093/annonc/mdz451
https://doi.org/10.1093/annonc/mdz451
Autor:
Geoffrey L. Uy, Amnon Peled, Osnat Bohana-Kashtan, Daniel C. Link, Jun Xia, Ella Sorani, Matthew Rm Jotte, Stephanie Sun, Abi Vainstein
Publikováno v:
Blood. 134:2745-2745
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that accounts for 10-15% of pediatric and 25% of adult ALL cases. CXCL12 is a CXC chemokine that is constitutively expressed at high levels in the bone marrow. CXCR4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6beea3f36bbc1e2782da9d1462cf36fa
https://doi.org/10.1182/blood-2019-128881
https://doi.org/10.1182/blood-2019-128881
Autor:
Daniel C. Link, Geoffrey L. Uy, Jonathan E. Brammer, Wendy Stock, John F. DiPersio, Tapan M. Kadia, Hemda Chen, Abi Vainstein, Osnat Bohana-Kashtan, Ella Sorani
Publikováno v:
Blood. 134:2630-2630
Background: The chemokine receptor, CXCR4, mediates the trafficking and retention of hematopoietic stem cells to the marrow through its interaction with the chemokine, CXCL12. CXCR4 is the most highly expressed chemokine receptor on T-ALL cells, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9770ed46268b785bcb61c71da55b720
https://doi.org/10.1182/blood-2019-127121
https://doi.org/10.1182/blood-2019-127121
Autor:
Alex Aizikovich, Alexander Konson, Nili Schutz, Alina Shitrit, Avihai Yacovan, Sima Mirilashvili, Rachel Ozeri, Daniel Sherman, Osnat Bohana-Kashtan, Oren M. Becker, Tzofit Kehat, Vered Behar, Efrat Ben-Zeev
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6460-6468
Cancer cells preferentially use glycolysis rather than oxidative phosphorylation for their rapid growth. They consume large amount of glucose to produce lactate even when oxygen is abundant, a phenomenon known as the Warburg effect. This metabolic ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79338c894668e99725151e301339abfd
https://doi.org/10.1016/j.bmcl.2012.08.054
https://doi.org/10.1016/j.bmcl.2012.08.054
Autor:
Peter Westervelt, Ella Sorani, Osnat Bohana-Kashtan, Michael P. Rettig, Samantha Jaglowski, Steven M. Devine, John F. DiPersio, Abi Vainstein, Hemda Chen, Asad Bashey, Stephen Shaw, Geoffrey L. Uy
Publikováno v:
Blood. 132:118-118
Background. Mobilized hematopoietic stem/progenitor cells (HSPCs) are the most commonly used graft source for hematopoietic cell transplantation (HCT). Current practices for harvesting HSPCs with G-CSF and/or plerixafor are costly, involve a multi-da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a3050e6939a02745d7e39f4a7a5221a
https://doi.org/10.1182/blood-2018-99-109701
https://doi.org/10.1182/blood-2018-99-109701
Autor:
Stephen Shaw, Abi Vainstein, Jun Xia, Ella Sorani, Stephanie Sun, Matthew Rm Jotte, Geoffrey L. Uy, Daniel C. Link, Osnat Bohana-Kashtan
Publikováno v:
Blood. 132:2700-2700
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that accounts for 10-15% of pediatric and 25% of adult ALL cases. Approximately 20-25% of pediatric and 50% of adult patients with T-ALL relapse following induction t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::584e4a7c33c0b39328d1e1427365568b
https://doi.org/10.1182/blood-2018-99-117213
https://doi.org/10.1182/blood-2018-99-117213
Publikováno v:
Transplantation. 82:471-478
Allogeneic bone marrow transplantation (BMT) and donor lymphocyte infusion (DLI) provide valuable treatments for a range of diseases. However, the therapeutic utility of BMT and DLI is reduced by the high incidence of graft-versus-host disease (GvHD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90340c515c2dc824e6cea061c9c30ae
https://doi.org/10.1097/01.tp.0000229435.58898.c5
https://doi.org/10.1097/01.tp.0000229435.58898.c5