GLP-2 Is Locally Produced From Human Islets and Balances Inflammation Through an Inter-Islet-Immune Cell Crosstalk

Autor: Wei He, Osmond D. Rebello, Antonia Henne, Fabian Nikolka, Thomas Klein, Kathrin Maedler

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Glucagon-like peptide-1 (GLP-1) shows robust protective effects on β-cell survival and function and GLP-1 based therapies are successfully applied for type-2 diabetes (T2D) and obesity. Another cleavage product of pro-glucagon, Glucagon-like peptide

Externí odkaz: https://doaj.org/article/9359f562c4114846818c92981c1b5bfc

Fucosidases from the human gut symbiont Ruminococcus gnavus

Autor: Samuel Walpole, Osmond D. Rebello, Haiyang Wu, Martin A. Walsh, Serena Monaco, Paulina A. Urbanowicz, Emmanuelle H. Crost, Didier Ndeh, Anna Colvile, Jesús Angulo, Daniel I. R. Spencer, C. David Owen, Nathalie Juge, Thomas Hicks, Chloe Bennati-Granier

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Cellular and Molecular Life Sciences
Digital.CSIC. Repositorio Institucional del CSIC

The availability and repartition of fucosylated glycans within the gastrointestinal tract contributes to the adaptation of gut bacteria species to ecological niches. To access this source of nutrients, gut bacteria encode α-l-fucosidases (fucosidase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c8eccedd9c993dbc2ee490ad597258

A Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Assay for the Relative Quantitation of Antennary Fucosylated

Autor: Osmond D, Rebello, Simone, Nicolardi, Guinevere S M, Lageveen-Kammeijer, Jan, Nouta, Richard A, Gardner, Wilma E, Mesker, Rob A E M, Tollenaar, Daniel I R, Spencer, Manfred, Wuhrer, David, Falck

Publikováno v: Frontiers in Chemistry

Changes in the abundance of antennary fucosylated glycans in human total plasma N-glycome (TPNG) have been associated with several diseases ranging from diabetes to various forms of cancer. However, it is challenging to address this important part of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d76af26772259d1658d16853d2298f0
https://pubmed.ncbi.nlm.nih.gov/32185163

Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

Autor: Neil G. Paterson, Justina Briliūtė, Paulina A. Urbanowicz, Ana S. Luis, Eric C. Martens, Arnaud Baslé, Osmond D. Rebello, Didier Ndeh, Elisabeth C. Lowe, Lucy I. Crouch, Daniel I. R. Spencer, Jenifer L. Hendel, David N. Bolam

Publikováno v: Nature Microbiology

Glycans are the major carbon sources available to the human colonic microbiota. Numerous N-glycosylated proteins are found in the human gut, from both dietary and host sources, including immunoglobulins such as IgA that are secreted into the intestin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a696ff5bcef10a5fc2f57360925f745