Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Osmar Norberto de Souza"'
Autor:
Lilian Cruz, Bence György, Pike See Cheah, Benjamin P. Kleinstiver, William A. Eimer, Sara P. Garcia, Nutan Sharma, Laurie J. Ozelius, D. Cristopher Bragg, J. Keith Joung, Osmar Norberto de Souza, Luis Fernando Saraiva Macedo Timmers, Xandra O. Breakefield
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 1-12 (2020)
Most individuals affected with DYT1 dystonia have a heterozygous 3-bp deletion in the TOR1A gene (c.907_909delGAG). The mutation appears to act through a dominant-negative mechanism compromising normal torsinA function, and it is proposed that reduci
Externí odkaz:
https://doaj.org/article/7258ef6927e544c29b5663dbd5f40e37
Autor:
Giulia Ramos Faillace, Paula Bacaicoa Caruso, Luis Fernando Saraiva Macedo Timmers, Débora Favero, Frank Lino Guzman, Ciliana Rechenmacher, Luisa Abruzzi de Oliveira-Busatto, Osmar Norberto de Souza, Christian Bredemeier, Maria Helena Bodanese-Zanettini
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Osmotins are multifunctional proteins belonging to the thaumatin-like family related to plant stress responses. To better understand the functions of soybean osmotins in drought stress response, the current study presents the characterisation of four
Externí odkaz:
https://doaj.org/article/b99e1d477d9b45199806f50bd197b922
Autor:
Renata Fioravanti Tarabini, Luís Fernando Saraiva Macedo Timmers, Carlos Eduardo Sequeiros-Borja, Osmar Norberto de Souza
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Flexibility is a feature intimately related to protein function, since conformational changes can be used to describe environmental changes, chemical modifications, protein-protein and protein-ligand interactions. In this study, we have inve
Externí odkaz:
https://doaj.org/article/2aa7a22fd26e4c11bc04ecb42ed434a5
Autor:
Matheus V.C. Grahl, Allan M. Alcará, Ana Paula A. Perin, Carlo F. Moro, Éderson S.M. Pinto, Bruno C. Feltes, Isadora M. Ghilardi, Felipe V.F. Rodrigues, Marcio Dorn, Jaderson C. da Costa, Osmar Norberto de Souza, Rodrigo Ligabue-Braun
Publikováno v:
Informatics in Medicine Unlocked, Vol 23, Iss , Pp 100539- (2021)
In 2020 SARS-CoV-2 reached pandemic status, reaching Brazil in mid-February. As of now, no specific drugs for treating the disease are available. In this work, the possibility of interaction between SARS-CoV-2 viral proteins (open and closed spike pr
Externí odkaz:
https://doaj.org/article/fda32d86fac24b0e9fea4dbe2d44959d
Autor:
Renata De Paris, Christian Vahl Quevedo, Duncan D. Ruiz, Furia Gargano, Osmar Norberto de Souza
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background In the rational drug design process, an ensemble of conformations obtained from a molecular dynamics simulation plays a crucial role in docking experiments. Some studies have found that Fully-Flexible Receptor (FFR) models predict
Externí odkaz:
https://doaj.org/article/471845d5b84a470bb11d91fc2c028932
Autor:
Thaís C Muradás, Bruno L Abbadi, Anne D Villela, Fernanda S Macchi, Pedro F Bergo, Talita F de Freitas, Nathalia D M Sperotto, Luis F S M Timmers, Osmar Norberto de Souza, Jaqueline N Picada, Jean Fachini, Juliana Bondan da Silva, Nayara C P de Albuquerque, Maísa D Habenschus, Daniel B Carrão, Bruno A Rocha, Fernando Barbosa Junior, Anderson R M de Oliveira, Alessandra Mascarello, Patrícia Neuenfeldf, Ricardo J Nunes, Héctor R Morbidoni, Maria M Campos, Luiz A Basso, Valnês S Rodrigues-Junior
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202568 (2018)
New effective compounds for tuberculosis treatment are needed. This study evaluated the effects of a series of quinoxaline-derived chalcones against laboratorial strains and clinical isolates of M. tuberculosis. Six molecules, namely N5, N9, N10, N15
Externí odkaz:
https://doaj.org/article/c7d8583f986f47f0b00f0dee6f5f32de
Autor:
Vanessa Stangherlin Machado Paixão-Cortes, Michele dos Santos da Silva Tanus, Walter Ritzel Paixão-Cortes, Osmar Norberto de Souza, Marcia de Borba Campos, Milene Selbach Silveira
Publikováno v:
Information, Vol 9, Iss 1, p 20 (2018)
Protein structure prediction servers use various computational methods to predict the three-dimensional structure of proteins from their amino acid sequence. Predicted models are used to infer protein function and guide experimental efforts. This can
Externí odkaz:
https://doaj.org/article/56a92c261f4c4a2092f9d98025ffa7fc
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133172 (2015)
Protein receptor conformations, obtained from molecular dynamics (MD) simulations, have become a promising treatment of its explicit flexibility in molecular docking experiments applied to drug discovery and development. However, incorporating the en
Externí odkaz:
https://doaj.org/article/c02ae4df50bd4efbb5905d9c795bfd33
Autor:
Nutan Sharma, Sara P. Garcia, Lilian Cruz, Pike See Cheah, Osmar Norberto de Souza, J. Keith Joung, Luis Fernando Saraiva Macedo Timmers, Bence György, William A. Eimer, D. Cristopher Bragg, Xandra O. Breakefield, Laurie J. Ozelius, Benjamin P. Kleinstiver
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 1-12 (2020)
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 1-12 (2020)
Most individuals affected with DYT1 dystonia have a heterozygous 3-bp deletion in the TOR1A gene (c.907_909delGAG). The mutation appears to act through a dominant-negative mechanism compromising normal torsinA function, and it is proposed that reduci
Autor:
Lucas Santos Chitolina, Osmar Norberto de Souza, Luiz Augusto Basso, Luís Fernando Saraiva Macedo Timmers
Publikováno v:
Journal of molecular modeling. 28(6)
Flexibility and function are related properties in the study of protein dynamics. Flexibility reflects in the conformational potential of proteins and thus in their functionalities. The presence of interactions between protein-ligands and protein-pro