Tick-borne Encephalitis Virus Vaccines Contain Non-structural Protein 1 (NS1) Antigen and May Elicit NS1-Specific Antibody Responses in Vaccinated Individuals

Autor: Zbyněk Zdráhal, Juraj Petrik, Dana Teislerova, Martin Palus, Jan Haviernik, Aleš Chrdle, Petra Formanová, Osmany Larralde, Daniel Ruzek, Jana Elsterová, Kamil Mikulášek, Jiri Salat, Ludek Eyer

Vaccination against tick-borne encephalitis (TBE) is based on the use of formalin-inactivated, culture-derived whole-virus vaccines. Immune response following vaccination is primarily directed to the viral envelope (E) protein, the major viral surfac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b553b87a5a7085015d390555040047

Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding

Autor: Poonam Malik, Osmany Larralde, Joel W.S. Smith, Ross C. Anderson, Sheila V. Graham, Barbara Gorgoni, Nicola K. Gray, Richard P. Smith, William A. Richardson

Publikováno v: Smith, R W P, Anderson, R C, Larralde, O, Smith, J W S, Gorgoni, B, Richardson, W A, Malik, P, Graham, S V & Gray, N K 2017, ' Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding ', Proceedings of the National Academy of Sciences, vol. 114, no. 24, pp. 6310-6315 . https://doi.org/10.1073/pnas.1610417114

Regulation of mRNA translation is a major control point for gene expression and is critical for life. Of central importance is the complex between cap-bound eukaryotic initiation factor 4E (eIF4E), eIF4G, and poly(A) tail-binding protein (PABP) that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7d4e62d1c83c13f1961b24778ca517
https://hdl.handle.net/20.500.11820/0fe702da-1199-4ad4-8160-e07255230b49

Lamination of the cerebral cortex is disturbed in Gli3 mutant mice

Autor: Thomas Theil, Thomas Skutella, Osmany Larralde, Melanie Friedrichs

Publikováno v: Friedrichs, M, Larralde, O, Skutella, T & Theil, T 2008, ' Lamination of the cerebral cortex is disturbed in Gli3 mutant mice ', Developmental Biology, vol. 318, no. 1, pp. 203-214 . https://doi.org/10.1016/j.ydbio.2008.03.032

The layered organization of the cerebral cortex develops in an inside-out pattern, a process which is controlled by the secreted protein reelin. Here we report on cortical lamination in the Gli3 hypomorphic mouse mutant Xt(J)/Pdn which lacks the cort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18dec49313fb7e8727f5ea3ef1d052d
https://doi.org/10.1016/j.ydbio.2008.03.032

Poly(A)-binding protein 1 partially relocalizes to the nucleus during herpes simplex virus type 1 infection in an ICP27-independent manner and does not inhibit virus replication

Autor: L. Howard, Hannah M. Burgess, K. Lochtie, Matthew Brook, A. I. MacDonald, Poonam Malik, Christine Salaün, Nicola K. Gray, Osmany Larralde, Sheila V. Graham

Publikováno v: Salaun, C, MacDonald, A I, Larralde, O, Howard, L, Lochtie, K, Burgess, H M, Brook, M, Malik, P, Gray, N K & Graham, S V 2010, ' Poly(A)-binding protein 1 partially relocalizes to the nucleus during herpes simplex virus type 1 infection in an ICP27-independent manner and does not inhibit virus replication ', Journal of Virology, vol. 84, no. 17, pp. 8539-8548 . https://doi.org/10.1128/JVI.00668-10

Infection of cells by herpes simplex virus type 1 (HSV-1) triggers host cell shutoff whereby mRNAs are degraded and cellular protein synthesis is diminished. However, virus protein translation continues because the translational apparatus in HSV-infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b60d25b11ac07518f0578305da327c6
https://www.pure.ed.ac.uk/ws/files/8341308/Poly_A_binding_protein_1_partially_relocalizes_to_the_nucleus_during_herpes_simplex_virus_type_1_infection_in_an_ICP27_independent_manner_and_does_not_inhibit_virus_replication.pdf

A novel triple fusion reporter system for use in gene trap mutagenesis

Autor: Joshua M. Brickman, Lesley M. Forrester, Elena Tzouanacou, Osmany Larralde, Anestis Tsakiridis, Tim M Watts, Valerie Wilson

Publikováno v: Genesis (New York, N.Y. : 2000). 45(6)

Gene trapping is an insertional mutagenesis strategy that allows for simultaneous gene identification and mutation in embryonic stem (ES) cells. Gene trap vectors both disrupt coding sequence and report on the genes' endogenous expression. The most p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d1c54526a974eb4b45a4310c9283fd
https://pubmed.ncbi.nlm.nih.gov/17492751