Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Osman Shabir"'
Autor:
Luke W. Boorman, Samuel S. Harris, Osman Shabir, Llywelyn Lee, Beth Eyre, Clare Howarth, Jason Berwick
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
A multimodal approach is developed in rats, which enables the interrogation of effects of temperature changes on neurovascular coupling.
Externí odkaz:
https://doaj.org/article/403d445fedda42e4b91ea86010dc1326
Autor:
Beth Eyre, Kira Shaw, Paul Sharp, Luke Boorman, Llywelyn Lee, Osman Shabir, Jason Berwick, Clare Howarth
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Investigating neurovascular coupling in awake rodents is becoming ever more popular due, in part, to our increasing knowledge of the profound impacts that anaesthesia can have upon brain physiology. Although awake imaging brings with it many
Externí odkaz:
https://doaj.org/article/052d21db476048348b63a531dd200bc9
Autor:
Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S Sharp, Monica A Rebollar, David Drew, Clare Howarth, Paul R Heath, Stephen B Wharton, Sheila E Francis, Jason Berwick
Publikováno v:
eLife, Vol 11 (2022)
Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. The breakdown of neurovascular coupling is linked to the development and progression of several neurological conditions including
Externí odkaz:
https://doaj.org/article/92e57f89b041496cb62439a786902073
Publikováno v:
BMC Neuroscience, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Efficient blood supply to the brain is of paramount importance to its normal functioning and improper blood flow can result in potentially devastating neurological consequences. Cerebral blood flow in response to neural activity is intrinsic
Externí odkaz:
https://doaj.org/article/f96857803dbe4e9fa2e62ce38d65eefe
Autor:
Tatyana A. Shelkovnikova, Michail S. Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul R. Heath, Vladimir L. Buchman
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-17 (2018)
Abstract Background Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA) NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral sclerosis (ALS) patients has been reported but underlying mechanisms
Externí odkaz:
https://doaj.org/article/32909fe494c245dd9eff4f5d0cc93bdf
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd9d0cf32c1253baaf9f35c8882e4514
https://doi.org/10.1002/alz.069266
https://doi.org/10.1002/alz.069266
Autor:
Osman Shabir
Publikováno v:
TheScienceBreaker. 8
In our study, we investigated a crucial brain blood flow regulation mechanism in mouse models of heart disease and dementia. We found that there was a breakdown of this crucial mechanism in the brains of mice with heart disease. Furthermore, the comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::026599c1efe822badbfb9804036693da
https://doi.org/10.25250/thescbr.brk642
https://doi.org/10.25250/thescbr.brk642
Autor:
Luke W. Boorman, Samuel S. Harris, Osman Shabir, Llywelyn Lee, Beth Eyre, Clare Howarth, Jason Berwick
Neurovascular coupling (NVC) is a mechanism that, amongst other known and latent critical functions, ensures activated brain regions are adequately supplied with oxygen and glucose. This biological phenomenon underpins non-invasive perfusion-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1959d3dcecde807a215b5776bd2b8241
https://doi.org/10.1101/2022.04.14.488315
https://doi.org/10.1101/2022.04.14.488315
Autor:
Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S Sharp, Monica A Rebollar, David Drew, Clare Howarth, Paul R Heath, Stephen B Wharton, Sheila E Francis, Jason Berwick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d44d1cd2ade9d853388b46b8b4e87fd
https://doi.org/10.7554/elife.68242.sa2
https://doi.org/10.7554/elife.68242.sa2
Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia
Autor:
Jason Berwick, Manmohi D Dake, Tobias Moll, Beth Eyre, Osman Shabir, Sheila E. Francis, Martyna M. Matuszyk
Publikováno v:
Mechanisms of ageing and development. 192
The use of animal models is fundamental to furthering our understanding of human disease mechanisms, as well as identifying potential therapeutic targets. Diseases of ageing often involve multiple body systems; however, multi-systemic features are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56af8fa1f6be11dcf1652035e97110c
https://pubmed.ncbi.nlm.nih.gov/32998028
https://pubmed.ncbi.nlm.nih.gov/32998028