Novel 3,6-Disubstituted Pyridazine Derivatives Targeting JNK1 Pathway: Scaffold Hopping and Hybridization-Based Design, Synthesis, Molecular Modeling, and In Vitro and In Vivo Anticancer Evaluation.

Autor: Shaalan MM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, Al-Sherouk City, Cairo-Suez Desert Road, Cairo 11837, Egypt., Osman EEA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt., Attia YM; Pharmacology Department, Faculty of Pharmacy, The British University in Egypt, Al-Sherouk City, Cairo-Suez Desert Road, Cairo 11837, Egypt., Hammam OA; Pathology Department, Theodor Bilharz Research Institute, Imbaba, Giza 12411, Egypt., George RF; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt., Naguib BH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, Al-Sherouk City, Cairo-Suez Desert Road, Cairo 11837, Egypt.; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.

Publikováno v: ACS omega [ACS Omega] 2024 Aug 19; Vol. 9 (35), pp. 37310-37329. Date of Electronic Publication: 2024 Aug 19 (Print Publication: 2024).

Platanosides from Platanus × acerifolia: New molecules, SAR, and target validation of a strong lead for drug-resistant bacterial infections and the associated sepsis.

Autor: Wu XY; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Zhejiang 318000, PR China; School of Pharmacy, Fudan University, Shanghai 201203, PR China; Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, PR China., Zhao ZY; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Zhejiang 318000, PR China; School of Pharmacy, Fudan University, Shanghai 201203, PR China., Osman EEA; Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornaish El-Nile St., Giza 12411, Egypt., Wang XJ; School of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, PR China; Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston 29425-5700, USA., Choo YM; Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. Electronic address: ymchoo@um.edu.my., Benjamin MM; Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston 29425-5700, USA., Xiong J; School of Pharmacy, Fudan University, Shanghai 201203, PR China., Hamann MT; Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston 29425-5700, USA. Electronic address: hamannm@musc.edu., Luo C; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China., Hu JF; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Zhejiang 318000, PR China; School of Pharmacy, Fudan University, Shanghai 201203, PR China; Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston 29425-5700, USA. Electronic address: jfhu@fudan.edu.cn.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Feb; Vol. 143, pp. 107103. Date of Electronic Publication: 2024 Jan 06.

Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer.

Autor: Roy J; Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States., Kyani A; Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States., Hanafi M; Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Xu Y; Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States., Takyi-Williams J; Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States.; Pharmaceutical Sciences, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States., Sun D; Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States.; Pharmaceutical Sciences, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States., Osman EEA; Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Neamati N; Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Feb 09; Vol. 66 (3), pp. 1990-2019. Date of Electronic Publication: 2023 Jan 24.

Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXV. Structurally diverse triterpenoids and diterpenoids from two endangered Pinaceae plants endemic to the Chinese Qinling Mountains and their bioactivities.

Autor: Jiang W; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Zhejiang, 318000, PR China; School of Life Science and Technology, Wuhan Polytechnic University, Hubei, 430023, PR China; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, PR China., Zhao ZY; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Zhejiang, 318000, PR China; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, PR China., Tong YP; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Zhejiang, 318000, PR China., Ma GL; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, PR China., Zang Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, PR China., Osman EEA; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, PR China; Department of Biochemistry, Molecular Biology and Medicinal Chemistry, Theodor Bilharz Research Institute, P. O. Box 30 Imbaba, Giza, 12411, Egypt., Jin ZX; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Zhejiang, 318000, PR China., Xiong J; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, PR China. Electronic address: jxiong@fudan.edu.cn., Li J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, PR China., Hu JF; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Zhejiang, 318000, PR China; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, PR China. Electronic address: jfhu@tzc.edu.cn.

Publikováno v: Phytochemistry [Phytochemistry] 2022 Nov; Vol. 203, pp. 113366. Date of Electronic Publication: 2022 Aug 12.

Bioassay-Guided Isolation of New Flavonoid Glycosides from Platanus × acerifolia Leaves and Their Staphylococcus aureus Inhibitory Effects.

Autor: Wu X; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China.; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Taizhou 318000, China.; Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China., Tang Y; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Osman EEA; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China.; Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornaish El-Nile St., Giza 12411, Egypt., Wan J; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Taizhou 318000, China., Jiang W; School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China., Yang G; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China., Xiong J; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China., Zhu Q; Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China., Hu JF; Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China.; Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Taizhou 318000, China.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 Aug 23; Vol. 27 (17). Date of Electronic Publication: 2022 Aug 23.