Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Osman, Dadas"'
Autor:
Monika Semmrich, Linda Mårtensson, Ingrid Teige, Björn Frendeus, Mathilda Kovacek, Petra Holmkvist, Carolin Svensson, Therese Blidberg, Andres McAllister, Marie Borggren, Ingrid Karlsson, Mark Cragg, Mimoza Bodén, Kirstie Cleary, Osman Dadas, Benjamin Duell, Jan Anders Nilsson, Stephen Beers, Sean Lim, Johan E Wallin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/e0e8b870548644bdb65e3e93dec0f252
Autor:
Osman Dadas, Joel D. Allen, Sarah L. Buchan, Jinny Kim, H. T. Claude Chan, C. Ian Mockridge, Patrick J. Duriez, Anne Rogel, Max Crispin, Aymen Al-Shamkhani
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionT cell expressed CD27 provides costimulation upon binding to inducible membrane expressed trimeric CD70 and is required for protective CD8 T cell responses. CD27 agonists could therefore be used to bolster cellular vaccines and anti-tumou
Externí odkaz:
https://doaj.org/article/1b431c0777aa4151a8bb65c2e1304139
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The tumor necrosis factor superfamily (TNFSF) and their receptors (TNFRSF) are important regulators of the immune system, mediating proliferation, survival, differentiation, and function of immune cells. As a result, their targeting for immunotherapy
Externí odkaz:
https://doaj.org/article/8b5755ed18974dd39aa3959d301a8ad5
Autor:
Franziska Heckel, Anna H. Turaj, Hayden Fisher, H. T. Claude Chan, Michael J. E. Marshall, Osman Dadas, Christine A. Penfold, Tatyana Inzhelevskaya, C. Ian Mockridge, Diego Alvarado, Ivo Tews, Tibor Keler, Stephen A. Beers, Mark S. Cragg, Sean H. Lim
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Agonistic CD27 monoclonal antibodies can be used to enhance the efficacy of depleting antibodies such as anti-CTLA-4 in a colon adenocarcinoma tumour model. CD27 antibody agonism is dependent on isotype and epitope specificity.
Externí odkaz:
https://doaj.org/article/f7e2de2c168f4f2984754369dc482291
Autor:
Franziska, Heckel, Anna H, Turaj, Hayden, Fisher, H T Claude, Chan, Michael J E, Marshall, Osman, Dadas, Christine A, Penfold, Tatyana, Inzhelevskaya, C Ian, Mockridge, Diego, Alvarado, Ivo, Tews, Tibor, Keler, Stephen A, Beers, Mark S, Cragg, Sean H, Lim
Publikováno v:
Communications biology. 5(1)
Agonistic CD27 monoclonal antibodies (mAb) have demonstrated impressive anti-tumour efficacy in multiple preclinical models but modest clinical responses. This might reflect current reagents delivering suboptimal CD27 agonism. Here, using a novel pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::219a5e95181abdd2dadaf5cdafe03532
https://pubmed.ncbi.nlm.nih.gov/35288635
https://pubmed.ncbi.nlm.nih.gov/35288635
Autor:
Linda Mårtensson, Kirsty Cleary, Petra Holmkvist, Mathilda Kovacek, Carolin Svensson, Monika Semmrich, Therese Blidberg, Mimoza Demiri, Osman Dadas, Marie Borggren, Vici Pitic, Sean H. Lim, Stephen A. Beers, Susanne Gertsson, Kristoffer S. Rohrberg, Ingrid Karlsson, Andres McAllister, Mark S. Cragg, Björn Frendeus, Ingrid Teige
Publikováno v:
Cancer Research. 82:4156-4156
The pleiotropic TNF-α:TNFR axis plays a central role in immune regulation. While the cellular expression of TNFR1 is broad, TNFR2 expression is mainly restricted to immune cells. The therapeutic potential of targeting TNFR2 for cancer treatment has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a48fd1dbbe02c1299113b91d04509751
https://doi.org/10.1158/1538-7445.am2022-4156
https://doi.org/10.1158/1538-7445.am2022-4156
Autor:
Gessa Sugiyarto, Tim Elliott, E David Arcia-Anaya, Eddie A. James, Osman Dadas, David Prossor
Publikováno v:
Immunotherapy Advances
Summary Objectives Regulatory T cells (Treg) play a major role in the suppression of protective anti-tumour T cell responses. In the CT26 BALB/c murine model of colorectal carcinoma, Tregs differentially suppress responses to two characterised CD8+ T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd709ba8c774170e4138ebc2440a482
http://europepmc.org/articles/PMC7958313
http://europepmc.org/articles/PMC7958313
Autor:
Jane E. Willoughby, Ivo Tews, Ruth R. French, Chris Orr, Ali Roghanian, Anne White, Stephen A. Beers, Martin J. Glennie, Xiaojie Yu, Mark S. Cragg, Hayden Fisher, Aymen Al-Shamkhani, Osman Dadas
Publikováno v:
Blood Cancer Discovery. 1:IA03-IA03
Agonistic antibodies directed to immunostimulatory receptors are a currently untapped source for immunotherapy. Whereas checkpoint blockers have translated into the clinic, the rules for agonistic antibodies have been more difficult to discern and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::135699569c9a53250acf43e6b28becda
https://doi.org/10.1158/2643-3249.lymphoma20-ia03
https://doi.org/10.1158/2643-3249.lymphoma20-ia03
Autor:
Caroline Svensson, Ulla-Carin Thornberg, Björn Frendéus, Therese Blidberg, Sean H. Lim, Stephen A. Beers, Mathilda Kovacek, Petra Holmkvist, Mimoza Demiri, Vincentiu Pitic, Monika Semmrich, Linda Mårtensson, Kirstie L. S. Cleary, Osman Dadas, Ingrid Teige, Mark S. Cragg
Publikováno v:
Cancer Research. 80:936-936
The pleiotropic TNF-α:TNFR axis plays a central role in the immune system. While the cellular expression of TNFR1 is broad, TNFR2 expression is mainly restricted to immune cells and especially high on T regs. The therapeutic potential of targeting T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e1ef2fe17d7d552cd54a0cbad2c05cf
https://doi.org/10.1158/1538-7445.am2020-936
https://doi.org/10.1158/1538-7445.am2020-936
Regulatory T cells (Treg) play a major role in the suppression of protective anti-tumour T cell responses. In the CT26 BALB/c murine model of colorectal carcinoma, Tregs differentially suppress responses to two characterised CD8+ T epitopes, AH1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8725e090090faea46bc68b21ab7898
