Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Oskar Lechner"'
Publikováno v:
Current Biology. 11:587-595
Peripheral T cell tolerance may result from activation-induced cell death [1], anergy [1], and/or immune response modulation by regulatory T cells [2] . In mice that express a transgenic receptor specific for peptide 111–119 of influenza hemaggluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f010885636d2860f1ca6ea610c1e107
https://doi.org/10.1016/s0960-9822(01)00160-9
https://doi.org/10.1016/s0960-9822(01)00160-9
Autor:
Adelaida Sarukhan, Carole Zober, Oskar Lechner, Ulrich Walter, Jan Buer, Anke Franzke, Harald von Boehmer
Publikováno v:
European Journal of Immunology. 30:1224-1232
Autoimmune diabetes results from destruction of pancreatic beta-cells by islet-infiltrating leukocytes. Different molecular mechanisms seem to be involved in this destruction but the results from many studies have not provided a clear picture so far.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::511737093f8ad4ca3df03d84ddaef893
https://doi.org/10.1002/1521-4141(200004)30:4<1224::aid-immu1224>3.0.co
https://doi.org/10.1002/1521-4141(200004)30:4<1224::aid-immu1224>3.0.co
Autor:
G. Jan Wiegers, Michael R. Waterman, Oskar Lechner, Hermann Dietrich, Georg Wick, Antonio J. Oliveira-dos-Santos, Richard L. Boyd, Heidrun Recheis
Publikováno v:
European Journal of Immunology. 30:337-346
Glucocorticoid hormones are known to act as important modulatory factors in the development of autoimmune diseases, and to play an important role in thymic T-cell selection. There seems to be a finely balanced equilibrium between the apoptosis-induci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbef0ec18df5cb707e70aeeec6ba075a
https://doi.org/10.1002/1521-4141(200002)30:2<337::aid-immu337>3.0.co
https://doi.org/10.1002/1521-4141(200002)30:2<337::aid-immu337>3.0.co
Publikováno v:
European Journal of Immunology. 29:3410-3416
Autoimmune diabetes develops following recognition of organ-specific antigens by T cells. The disease begins with peri-islet infiltration by mononuclear cells, proceeds with insulitis and becomes manifest with destruction of insulin-producing islet b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f9dd0be82467fca7dc10a70df3fe346
https://doi.org/10.1002/(sici)1521-4141(199910)29:10<3410::aid-immu3410>3.0.co
https://doi.org/10.1002/(sici)1521-4141(199910)29:10<3410::aid-immu3410>3.0.co
Autor:
Ulrich Walter, Jan Buer, Orly Azogui, Claude Saint-Ruf, Iannis Aifantis, Oskar Lechner, Jacqueline Feinberg, Harald von Boehmer
Publikováno v:
Current Opinion in Immunology. 11:135-142
The construction of various gene-deficient mice has facilitated the understanding of the role of various receptors and signaling pathways that control the generation of alphabeta lineage cells. A predominant role is occupied by the pre-TCR, which not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685ef1f13bc592bf78f461201ad02458
https://doi.org/10.1016/s0952-7915(99)80024-7
https://doi.org/10.1016/s0952-7915(99)80024-7
Publikováno v:
European Journal of Immunology. 28:3824-3831
The pre-TCR, which is minimally composed of the TCRbeta chain, the pre-Talpha chain, and the CD3 complex, regulates early T cell development. The pre-Talpha chain is a 33-kDa type I transmembrane glycoprotein with an extracellular part similar to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f4068e04ee01b243fb4fcc7da043ec
https://doi.org/10.1002/(sici)1521-4141(199811)28:11<3824::aid-immu3824>3.0.co
https://doi.org/10.1002/(sici)1521-4141(199811)28:11<3824::aid-immu3824>3.0.co
Publikováno v:
Annals of the New York Academy of Sciences. 840:591-598
According to our concept, the development of autoimmune disease depends on the presence of two sets of essential genes, one coding for an abnormal autoreactivity of the immune system, the other for a primary susceptibility of the target organ/structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4afa99535a9c95b1499a3bf229cef80
https://doi.org/10.1111/j.1749-6632.1998.tb09598.x
https://doi.org/10.1111/j.1749-6632.1998.tb09598.x
Autor:
Siegfried Schwarz, Mehrnaz Jafarian-Tehrani, Oskar Lechner, Hermann Dietrich, F. Haour, Yanhua Hu, Manfred Herold, Georg Wick
Publikováno v:
Brain, Behavior, and Immunity. 10:337-350
Immune reactions and mitogen stimulation of mammals and chickens lead to an increase of glucocorticoid (GC) plasma levels concomitant with the immune response. Interleukin (IL) 1, one of the most important glucocorticoid increasing factors produced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3d716c173894d5d1057286492d5e04
https://doi.org/10.1006/brbi.1996.0030
https://doi.org/10.1006/brbi.1996.0030
Autor:
Stefan R. Bornstein, Ulrich Walter, T. Toepfer, Oskar Lechner, Jörg Lauber, Karsten Kretschmer, H. von Boehmer, G. Servos, Kurt E.J. Dittmar, S. Weiss, Jan Buer, Werner A. Scherbaum
Publikováno v:
Diabetologia. 46(8)
In the NOD mouse model, attempts to show MHC class II expression by pancreatic beta cells were unsuccessful so far. We readdressed this question by analysing I-A(g7) expression in single pancreatic beta cells.Single-cell multiplex RT PCR and single-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95c77fdc3fe1f62ae52f5b905ec1d33
https://pubmed.ncbi.nlm.nih.gov/14666365
https://pubmed.ncbi.nlm.nih.gov/14666365
Autor:
Jan Buer, Anke Franzke, M Templin, T Wollensak, Patricia Gatzlaff, Michael Mengel, Andres J. Schrader, Jens Atzpodien, Kurt E.J. Dittmar, Michael Probst-Kepper, S Machtens, Oskar Lechner, Jörg Lauber
Publikováno v:
British Journal of Cancer
CXCL12 (SDF-1), a CXC-chemokine, and its specific receptor, CXCR4, have recently been shown to be involved in tumourgenesis, proliferation and angiogenesis. Therefore, we analysed CXCL12α/CXCR4 expression and function in four human kidney cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3af0b2811c9370d6e46be3107a2c21
https://pubmed.ncbi.nlm.nih.gov/11953881
https://pubmed.ncbi.nlm.nih.gov/11953881