Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Oskar Laur"'
Autor:
Dongdong Chen, Julie Cox, Jayabhargav Annam, Melanie Weingart, Grace Essien, Komal S. Rathi, Jo Lynne Rokita, Priya Khurana, Selma M. Cuya, Kristopher R. Bosse, Adeiye Pilgrim, Daisy Li, Cara Shields, Oskar Laur, John M. Maris, Robert W. Schnepp
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 6, Pp 231-241 (2020)
Neuroblastoma is an aggressive pediatric malignancy of the neural crest with suboptimal cure rates and a striking predilection for widespread metastases, underscoring the need to identify novel therapeutic vulnerabilities. We recently identified the
Externí odkaz:
https://doaj.org/article/ad151ae47c9f49dea91c5b91b570dcb8
Autor:
Tatiana A. Chernova, Denis A. Kiktev, Andrey V. Romanyuk, John R. Shanks, Oskar Laur, Moiez Ali, Abheek Ghosh, Dami Kim, Zhen Yang, Maggie Mang, Yury O. Chernoff, Keith D. Wilkinson
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 751-761 (2017)
Self-perpetuating ordered protein aggregates (amyloids and prions) are associated with a variety of neurodegenerative disorders. Although environmental agents have been linked to certain amyloid diseases, the molecular basis of their action remains u
Externí odkaz:
https://doaj.org/article/64f3aebe6f7847429f12c88c37d94f93
Autor:
Melanie Weingart, Robert W. Schnepp, Komal S. Rathi, John M. Maris, Dongdong Chen, Julie Cox, Cara E. Shields, Kristopher R. Bosse, Priya Khurana, Adeiye Pilgrim, Jo Lynne Rokita, Oskar Laur, Jayabhargav Annam, Grace Essien, Daisy Li, Selma M. Cuya
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 6, Pp 231-241 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Neuroblastoma is an aggressive pediatric malignancy of the neural crest with suboptimal cure rates and a striking predilection for widespread metastases, underscoring the need to identify novel therapeutic vulnerabilities. We recently identified the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4309a39836c5206ace6754e084152a50
https://doi.org/10.1016/j.neo.2020.04.001
https://doi.org/10.1016/j.neo.2020.04.001
Autor:
Ge Bai, John Shires, Kyla C Ugwu, Richard A. Willis, John D. Altman, Kelly Jeter, Vasanthi Ramachandiran, Dale L Long, Susana Contreras-Alcantara, Tamara Kazarian, Oskar Laur, Donielle L. Bell, Lixia Han
Publikováno v:
Curr Protoc
Class II major histocompatibility complex peptide (MHC-IIp) multimers are precisely engineered reagents used to detect T cells specific for antigens from pathogens, tumors, and self-proteins. While the related Class I MHC/peptide (MHC-Ip) multimers a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3820c512129cd889c3cdb461362dfd58
https://europepmc.org/articles/PMC7880703/
https://europepmc.org/articles/PMC7880703/
Autor:
Lake Rabenold, Duc M. Duong, Isaac Bishof, Juan C. Troncoso, Madhav Thambisetty, Ian Diner, Nicholas T. Seyfried, James J. Lah, Oskar Laur, Allan I. Levey, Chadwick M. Hales, Hong Yi, Marla Gearing
Publikováno v:
Journal of Biological Chemistry. 289:35296-35313
Recent evidence indicates that U1-70K and other U1 small nuclear ribonucleoproteins are Sarkosyl-insoluble and associate with Tau neurofibrillary tangles selectively in Alzheimer disease (AD). Currently, the mechanisms underlying the conversion of so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e272d45de8b90906c90cd1df449d11
https://doi.org/10.1074/jbc.m114.562959
https://doi.org/10.1074/jbc.m114.562959
Autor:
Sindhu Subramanian, Nicholas T. Seyfried, Luming Yin, Gary P. Newnam, Andrew K. Lee, Yury O. Chernoff, Tatiana A. Chernova, Oskar Laur, Dami Kim, Keith D. Wilkinson, Moiez Ali, James G. McNally, John R. Shanks, Tatiana S. Karpova
Publikováno v:
Journal of Biological Chemistry. 289:27625-27639
Yeast prions are self-propagating amyloid-like aggregates of Q/N-rich protein that confer heritable traits and provide a model of mammalian amyloidoses. [PSI(+)] is a prion isoform of the translation termination factor Sup35. Propagation of [PSI(+)]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965f985d60c7731602fe34c79f55c836
https://doi.org/10.1074/jbc.m114.582429
https://doi.org/10.1074/jbc.m114.582429
Publikováno v:
Journal of Cellular Biochemistry. 115:476-487
A- and C-type lamins are intermediate filament proteins responsible for the maintenance of nuclear shape and most likely nuclear architecture. Here, we propose that pronounced invaginations of A/C-type lamins into the nuclear interior represent chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45c5b12b016942553d3ba2e73e82f72
https://doi.org/10.1002/jcb.24681
https://doi.org/10.1002/jcb.24681
Autor:
Charles A. Parkos, Porfirio Nava, Stefan Koch, Asma Nusrat, Timothy L. Denning, Hector Romo-Parra, Ryuta Kamekura, Aurora Candelario, Oskar Laur, Ross Hamilton, Miguel Quiros, Oscar Medina-Contreras, Roland Hilgarth, Keli Kolegraff
Publikováno v:
Molecular Biology of the Cell
Nuclear Akt1 phosphorylates 14.3.3ζ at serine 58 to inhibit β-catenin transactivation. The results outline a dual function of Akt1, which suppresses intestinal epithelial cell proliferation during intestinal inflammation.
The proinflammatory c
The proinflammatory c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa1ae4a7c086f1665b5d0b7eb0c5597
http://europepmc.org/articles/PMC4230580
http://europepmc.org/articles/PMC4230580
Autor:
Andrey V. Romanyuk, Keith D. Wilkinson, Oskar Laur, Maggie Mang, Dami Kim, Yury O. Chernoff, Moiez Ali, John R. Shanks, Zhen Yang, Abheek Ghosh, Denis A. Kiktev, Tatiana A. Chernova
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 751-761 (2017)
Self-perpetuating ordered protein aggregates (amyloids and prions) are associated with a variety of neurodegenerative disorders. Although environmental agents have been linked to certain amyloid diseases, the molecular basis of their action remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9442dc1b019cdf435e5e6aa3b51df0a8
https://pubmed.ncbi.nlm.nih.gov/28099852
https://pubmed.ncbi.nlm.nih.gov/28099852
Autor:
Alexander Z. Robin, Dominique A. Weber, Oskar Laur, Charles A. Parkos, Winston Y. Lee, Rakieb Andargachew, Dennis R. Voelker, Bénédicte Fournier
Publikováno v:
Journal of Biological Chemistry. 287:19386-19398
Signal regulatory protein α (SIRPα), a highly glycosylated type-1 transmembrane protein, is composed of three immunoglobulin-like extracellular loops as well as a cytoplasmic tail containing three classical tyrosine-based inhibitory motifs. Previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a0a3ada9723050e03dc2cc59721c73
https://doi.org/10.1074/jbc.m111.324533
https://doi.org/10.1074/jbc.m111.324533