Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Oskar Knittelfelder"'
Publikováno v:
Microbial Cell, Vol 11, Pp 57-68 (2024)
Lipidomic analysis in diverse biological settings has be-come a frequent tool to increase our understanding of the processes of life. Cellular lipids play important roles not only as being the main components of cellular membranes, but also in the re
Externí odkaz:
https://doaj.org/article/e6183d0593c74617913d6e11bf2cc3cf
Autor:
Jack Davis, Thorsten Meyer, Martin Smolnig, Daniel G.J. Smethurst, Lisa Neuhaus, Jonas Heyden, Filomena Broeskamp, Elizabeth S.M. Edrich, Oskar Knittelfelder, Dagmar Kolb, Tobias von der Haar, Campbell W. Gourlay, Patrick Rockenfeller
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107539- (2023)
Summary: The dynamic nature of the actin cytoskeleton is required to coordinate many cellular processes, and a loss of its plasticity has been linked to accelerated cell aging and attenuation of adaptive response mechanisms. Cofilin is an actin-bindi
Externí odkaz:
https://doaj.org/article/be50f411dace449ba5f7ff725e47e81c
Autor:
Victor Girard, Florence Jollivet, Oskar Knittelfelder, Marion Celle, Jean-Noel Arsac, Gilles Chatelain, Daan M Van den Brink, Thierry Baron, Andrej Shevchenko, Ronald P Kühnlein, Nathalie Davoust, Bertrand Mollereau
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009921 (2021)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein (αSyn) aggregation and associated with abnormalities in lipid metabolism. The accumulation of lipids in cytoplasmic organelles called lipid droplets (LDs) was
Externí odkaz:
https://doaj.org/article/703475648ac1456b96f0b77a62b8af93
Autor:
Mukesh Kumar, Canan Has, Khanh Lam-Kamath, Sophie Ayciriex, Deepshe Dewett, Mhamed Bashir, Clara Poupault, Kai Schuhmann, Oskar Knittelfelder, Bharath Kumar Raghuraman, Robert Ahrends, Jens Rister, Andrej Shevchenko
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1083 (2022)
The requirement of vitamin A for the synthesis of the visual chromophore and the light-sensing pigments has been studied in vertebrate and invertebrate model organisms. To identify the molecular mechanisms that orchestrate the ocular response to vita
Externí odkaz:
https://doaj.org/article/0eb43aaadd854db1a2466198d3e4489c
Autor:
Tingting Fu, Oskar Knittelfelder, Olivier Geffard, Yohann Clément, Eric Testet, Nicolas Elie, David Touboul, Khedidja Abbaci, Andrej Shevchenko, Jerome Lemoine, Arnaud Chaumot, Arnaud Salvador, Davide Degli-Esposti, Sophie Ayciriex
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102115- (2021)
Summary: Sentinel species are playing an indispensable role in monitoring environmental pollution in aquatic ecosystems. Many pollutants found in water prove to be endocrine disrupting chemicals that could cause disruptions in lipid homeostasis in aq
Externí odkaz:
https://doaj.org/article/4e103fea0472490aa8775c4c8823c58e
Autor:
Christoph Heier, Oskar Knittelfelder, Harald F Hofbauer, Wolfgang Mende, Ingrid Pörnbacher, Laura Schiller, Gabriele Schoiswohl, Hao Xie, Sebastian Grönke, Andrej Shevchenko, Ronald P Kühnlein
Publikováno v:
eLife, Vol 10 (2021)
Triacylglycerol (TG) and steryl ester (SE) lipid storage is a universal strategy to maintain organismal energy and membrane homeostasis. Cycles of building and mobilizing storage fat are fundamental in (re)distributing lipid substrates between tissue
Externí odkaz:
https://doaj.org/article/f44cb629f0a14f5886e00d24a7b6c7ad
Autor:
Olga Vvedenskaya, Tim Daniel Rose, Oskar Knittelfelder, Alessandra Palladini, Judith Andrea Heidrun Wodke, Kai Schuhmann, Jacobo Miranda Ackerman, Yuting Wang, Canan Has, Mario Brosch, Veera Raghavan Thangapandi, Stephan Buch, Thomas Züllig, Jürgen Hartler, Harald C. Köfeler, Christoph Röcken, Ünal Coskun, Edda Klipp, Witigo von Schoenfels, Justus Gross, Clemens Schafmayer, Jochen Hampe, Josch Konstantin Pauling, Andrej Shevchenko
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100104- (2021)
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly understood. Using high-resolution shotgun mass spectrometry, we quantified the mol
Externí odkaz:
https://doaj.org/article/baf15b6381f843daa555ad1b8cabc9ef
Autor:
Filomena Broeskamp, Elizabeth S. M. Edrich, Oskar Knittelfelder, Lisa Neuhaus, Thorsten Meyer, Jonas Heyden, Lukas Habernig, Florian Kreppel, Campbell W. Gourlay, Patrick Rockenfeller
Publikováno v:
Cells, Vol 10, Iss 9, p 2416 (2021)
Autophagy is a cellular recycling program which efficiently reduces the cellular burden of ageing. Autophagy is characterised by nucleation of isolation membranes, which grow in size and further expand to form autophagosomes, engulfing cellular mater
Externí odkaz:
https://doaj.org/article/1a6f54ffecae44a8a599bd8710dcc9dc
Autor:
Martina Schweiger, Matthias Romauch, Renate Schreiber, Gernot F. Grabner, Sabrina Hütter, Petra Kotzbeck, Pia Benedikt, Thomas O. Eichmann, Sohsuke Yamada, Oskar Knittelfelder, Clemens Diwoky, Carina Doler, Nicole Mayer, Werner De Cecco, Rolf Breinbauer, Robert Zimmermann, Rudolf Zechner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The enzyme Atgl participates in the breakdown of lipids in adipose tissue. Here the authors show that pharmacological inhibition of Atgl reduces weight gain and improves metabolic health in mice fed a high-fat diet, without causing adverse effects in
Externí odkaz:
https://doaj.org/article/6897b936ca4b4463ba1c491fe09495d6
Autor:
Albert Thommen, Steffen Werner, Olga Frank, Jenny Philipp, Oskar Knittelfelder, Yihui Quek, Karim Fahmy, Andrej Shevchenko, Benjamin M Friedrich, Frank Jülicher, Jochen C Rink
Publikováno v:
eLife, Vol 8 (2019)
Kleiber’s law, or the 3/4 -power law scaling of the metabolic rate with body mass, is considered one of the few quantitative laws in biology, yet its physiological basis remains unknown. Here, we report Kleiber’s law scaling in the planarian Schm
Externí odkaz:
https://doaj.org/article/9d111b98f2b0407e9fd964f430ecd904