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Publikováno v:
Journal of Cell Science. May2020, Vol. 133 Issue 10, p1-1. 1p.
Autor:
Mathilda M. Willoughby, Arushi Saini, Iryna Bohovych, Amit R. Reddi, Oleh Khalimonchuk, Jonathan V. Dietz, Amy E. Medlock, Osiris Martinez-Guzman
Publikováno v:
Journal of Cell Science.
Heme is a cofactor and signaling molecule that is essential for much of aerobic life. All heme-dependent processes in eukaryotes require that heme is trafficked from its site of synthesis in the mitochondria to hemoproteins located throughout the cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f04ea186cbbfa0af9457843f5fa9f131
https://doi.org/10.1242/jcs.237917
https://doi.org/10.1242/jcs.237917
Autor:
David A. Hanna, Hyojung Kim, Rebecca Hu, Amit R. Reddi, Osiris Martinez-Guzman, Matthew P. Torres
Publikováno v:
Journal of Biological Chemistry. 293:12378-12393
Protoheme (hereafter referred to as heme) is an essential cellular cofactor and signaling molecule that is also potentially cytotoxic. To mitigate heme toxicity, heme synthesis and degradation are tightly coupled to heme utilization in order to limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b45b4c3a3b4d57333546fb1844090b
https://doi.org/10.1074/jbc.ra118.002125
https://doi.org/10.1074/jbc.ra118.002125
Autor:
Oleh Khalimonchuk, Osiris Martinez-Guzman, Jonathan V. Dietz, Iryna Bohovych, Amit R. Reddi, Amy E. Medlock
Heme is an essential cofactor and signaling molecule. All heme-dependent processes require that heme is trafficked from its site of synthesis in the mitochondria to hemoproteins in virtually every subcellular compartment. However, the mechanisms gove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9106d438499c95b8f45b913d14773393
Autor:
Anuradha Bharara Singh, Ritu Chakravarti, Elizabeth A. Sweeny, Luciana Hannibal, Dennis J. Stuehr, Arushi Saini, Pablo D. Dans, Greer Garee, Osiris Martinez-Guzman, Amit R. Reddi, Mohammad Mahfuzul Haque
Cellular heme is thought to be distributed between a pool of sequestered heme that is tightly bound within hemeproteins and a labile heme pool required for signaling and transfer into proteins. A heme chaperone that can hold and allocate labile heme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c367dbe254a910180e3c406e3f10e712
https://europepmc.org/articles/PMC6139559/
https://europepmc.org/articles/PMC6139559/
Publikováno v:
Biochemistry. 56(13)
Heme (iron protoporphyrin IX) is an essential protein prosthetic group and signaling molecule required for most life on Earth. All heme-dependent processes require the dynamic and rapid mobilization of heme from sites of synthesis or uptake to hemopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1279dfbdce427f3a9233a1c416665c2f
https://pubmed.ncbi.nlm.nih.gov/28316240
https://pubmed.ncbi.nlm.nih.gov/28316240
Autor:
Gheevarghese Raju, Xiaojing Yuan, Iqbal Hamza, F. Wayne Outten, Raven M. Harvey, David A. Hanna, Amit R. Reddi, Bindu Chandrasekharan, Osiris Martinez-Guzman
Heme is an essential cofactor and signaling molecule. Heme acquisition by proteins and heme signaling are ultimately reliant on the ability to mobilize labile heme (LH). However, the properties of LH pools, including concentration, oxidation state, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9182b691fece3b4ea76d970a58862682
https://europepmc.org/articles/PMC4941510/
https://europepmc.org/articles/PMC4941510/
Autor:
Osiris Martinez-Guzman, Oleh Khalimonchuk, Amit R. Reddi, Amy E. Medlock, Iryna Bohovych, Jonathan V. Dietz
Publikováno v:
Free Radical Biology and Medicine. 128:S51
Heme is an essential cofactor involved in a plethora of vital functions. Heme is required to be in most subcellular compartments, but the way, in which it is transported from the mitochondria - its site of synthesis - to those compartments is poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c5d411f12c2585de04f846957984df2
https://doi.org/10.1016/j.freeradbiomed.2018.10.088
https://doi.org/10.1016/j.freeradbiomed.2018.10.088
Autor:
Edmarie Martinez, Vivian Rodriguez Cruz, Vibha Bansal, Amaris Borges, Yiaslin Ruiz Reyes, Ezio Fasoli, Alexandra Rosado, Osiris Martinez Guzman
Despite membrane-based separations offering superior alternative to packed bed chromatographic processes, there has been a substantial lacuna in their actual application to separation processes. One of the major reasons behind this is the lack of ava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d59dc2cdb7fdcfc1d38c4a86c84a71
https://europepmc.org/articles/PMC3687526/
https://europepmc.org/articles/PMC3687526/