Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Osigwe Esue"'
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8855 (2010)
Crescentin, the recently discovered bacterial intermediate filament protein, organizes into an extended filamentous structure that spans the length of the bacterium Caulobacter crescentus and plays a critical role in defining its curvature. The mecha
Externí odkaz:
https://doaj.org/article/d66bd1ee9d134d6497f7961bf32b3cee
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4411 (2009)
The close subcellular proximity of different actin filament crosslinking proteins suggests that these proteins may cooperate to organize F-actin structures to drive complex cellular functions during cell adhesion, motility and division. Here we hypot
Externí odkaz:
https://doaj.org/article/cdb6c25f0d5b481cba63fcb3591c9cf0
Publikováno v:
Pharmaceutical Research. 26:2478-2485
This paper shows the first ever assembly of monoclonal antibody using multivalent carboxylate ions into highly ordered structures that feature viscoelastic properties reminiscent of other filamentous proteins.A monoclonal antibody was assembled into
Publikováno v:
Journal of Molecular Biology. 384:324-334
Formins are multidomain proteins that regulate actin filament dynamics and are defined by the formin homology 2 domain. Biochemical assays suggest that mammalian formins display actin-filament nucleation, severing, and bundling activities. Whether fo
Publikováno v:
Journal of Biological Chemistry. 281:30393-30399
The assembly and organization of the three major eukaryotic cytoskeleton proteins, actin, microtubules, and intermediate filaments, are highly interdependent. Through evolution, cells have developed specialized multifunctional proteins that mediate t
Publikováno v:
Journal of Bacteriology. 188:968-976
MreB, a major component of the recently discovered bacterial cytoskeleton, displays a structure homologous to its eukaryotic counterpart actin. Here, we study the assembly and mechanical properties of Thermotoga maritima MreB in the presence of diffe
Publikováno v:
Journal of Biological Chemistry. 279:1819-1826
Reconstituted actin filament networks have been used extensively to understand the mechanics of the actin cortex and decipher the role of actin cross-linking proteins in the maintenance and deformation of cell shape. However, studies of the mechanica
Autor:
William J. Galush, Kelly A. Schwarz, Yilma T. Adem, Thomas W. Patapoff, Eileen T. Duenas, Osigwe Esue
Publikováno v:
Bioconjugate chemistry. 25(4)
The conjugation of hydrophobic cytotoxic agents such as monomethyl auristatin E (MMAE) to the interchain sulfhydryl groups of monoclonal antibodies (Mabs) through a protease-labile linker generates a heterogeneous drug load distribution. The conjugat
Autor:
Yilma T. Adem, Alavattam Sreedhara, Osigwe Esue, Patricia Molina, Thomas W. Patapoff, Hongbin Liu
Publikováno v:
Journal of pharmaceutical sciences. 103(2)
We investigated the photo-protective effect of sugar-based surfactants—hexyl glucoside and hexyl maltoside—against light-induced oxidation of a monoclonal antibody. Reactive oxygen species are generated in solutions in the presence of light; thes
Although extensively studied, protein–protein interactions remain highly elusive and are of increasing interest in drug development. We show the assembly of a monoclonal antibody, using multivalent carboxylate ions, into highly-ordered structures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14894f3fdbf33cdd416a3a5dfc6db44a
https://europepmc.org/articles/PMC3893242/
https://europepmc.org/articles/PMC3893242/