Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

Autor: Payne, RO, Silk, SE, Elias, SC, Miura, K, Diouf, A, Galaway, F, de Graaf, H, Brendish, NJ, Poulton, ID, Griffiths, OJ, Edwards, NJ, Jin, J, Labbé, GM, Alanine, DG, Siani, L, Di Marco, S, Roberts, R, Green, N, Berrie, E, Ishizuka, A.S., Nielsen, C.M., Bardelli, M., Partey, F.D., Ofori, M.F., Barfod, L., Wambua, J., Murungi, L.M., Osier, F.H., Biswas, S., McCarthy, J.S., Minassian, A.M., Ashfield, R., Viebig, N.K., Nugent, F.L., Douglas, A.D., Vekemans, J., Wright, G.J., Faust, S.N., Hill, A.V., Long, C.A., Lawrie, A.M., Draper, S.J.

Publikováno v: Payne, R O, Silk, S E, Elias, S C, Miura, K, Diouf, A, Galaway, F, de Graaf, H, Brendish, N J, Poulton, I D, Griffiths, O J, Edwards, N J, Jin, J, Labbé, G M, Alanine, D G, Siani, L, Di Marco, S, Roberts, R, Green, N, Berrie, E, Ishizuka, A S, Nielsen, C M, Bardelli, M, Partey, F D, Ofori, M F, Barfod, L, Wambua, J, Murungi, L M, Osier, F H, Biswas, S, McCarthy, J S, Minassian, A M, Ashfield, R, Viebig, N K, Nugent, F L, Douglas, A D, Vekemans, J, Wright, G J, Faust, S N, Hill, A V, Long, C A, Lawrie, A M & Draper, S J 2017, ' Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions ', JCI insight, vol. 2, no. 21, e96381 . https://doi.org/10.1172/jci.insight.96381

The development of a highly effective vaccine remains a key strategic goal to aid the control and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte-binding protein homolog 5 (RH5) has emerged as the most promisi

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The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum.

Autor: Takashima, Eizo¹ (AUTHOR) morita.masayuki.ls@ehime-u.ac.jp, Otsuki, Hitoshi² (AUTHOR) otsuki@tottori-u.ac.jp, Morita, Masayuki¹ (AUTHOR) nhikvip@tmd.ac.jp, Ito, Daisuke² (AUTHOR) dito@tottori-u.ac.jp, Nagaoka, Hikaru¹ (AUTHOR) ilyiukie@gmail.com, Yuguchi, Takaaki¹ (AUTHOR) ifra.razaq3627@gmail.com, Hassan, Ifra¹ (AUTHOR), Tsuboi, Takafumi³ (AUTHOR) takashima.eizo.mz@ehime-u.ac.jp

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New Derivatives of the Multi-Stage Active Malaria Box Compound MMV030666 and Their Antiplasmodial Potencies.

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