Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers

Autor: Amiram Sananes, Itay Cohen, Irit Allon, Oshrit Ben‐David, Raghda Abu Shareb, Ksenia M. Yegodayev, David Stepensky, Moshe Elkabets, Niv Papo

Publikováno v: Molecular Oncology, Vol 17, Iss 11, Pp 2337-2355 (2023)

Targeted therapies for prostate, breast, and ovarian cancers are based on their activity against primary tumors rather than their anti‐metastatic activity. Consequently, there is an urgent need for new agents targeting the metastatic process. Emerg

Externí odkaz: https://doaj.org/article/a4cefe3f8f3c47aea4beb5cc1ffd954a

Molecular Insights into Bacteriophage Evolution toward Its Host

Autor: Marina de Leeuw, Maayan Baron, Oshrit Ben David, Ariel Kushmaro

Publikováno v: Viruses, Vol 12, Iss 10, p 1132 (2020)

Bacteriophages (phages), viruses that infect bacteria, are considered to be highly host-specific. To add to the knowledge about the evolution and development of bacteriophage speciation toward its host, we conducted a 21-day experiment with the broad

Externí odkaz: https://doaj.org/article/f6d5a210dd2b4aaca0ab423b883ac713

Molecular insights into bacteriophage evolution toward its host

Autor: Maayan Baron, Marina de Leeuw, Ariel Kushmaro, Oshrit Ben David

Publikováno v: de Leeuw, M, Baron, M, David, O B & Kushmaro, A 2020, ' Molecular insights into bacteriophage evolution toward its host ', Viruses, vol. 12, no. 10, 1132 . https://doi.org/10.3390/v12101132
Viruses, Vol 12, Iss 1132, p 1132 (2020)
Viruses
Volume 12
Issue 10

Bacteriophages (phages), viruses that infect bacteria, are considered to be highly host-specific. To add to the knowledge about the evolution and development of bacteriophage speciation toward its host, we conducted a 21-day experiment with the broad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7900e4a9fe75a65dc749270aac69ca4a
https://orbit.dtu.dk/en/publications/5e96dd8d-07da-4a9b-a07f-bbdb79b0a469

Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine

Autor: Anat Shahar, Ariel Afek, Oshrit Ben-David, Zachery Mielko, Raz Zarivach, Yael Belo, Hila Nudelman, Raluca Gordan, Eyal Arbely

Publikováno v: Biochim Biophys Acta Gen Subj

The signal transducer and activator of transcription 3 (STAT3) protein is activated by phosphorylation of a specific tyrosine residue (Tyr705) in response to various extracellular signals. STAT3 activity was also found to be regulated by acetylation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dfae8094ecd15a8409146fa92f50ee
https://doi.org/10.1101/537696

Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy

Autor: Lis Hasholt, Michael Tsoory, Anthony H. Futerman, Rikke S. Møller, Laura L. Klitten, Jan Larsen, Andrés D. Klein, Nils J. Færgeman, Jørgen E Nielsen, John Vissing, Helle Hjalgrim, Ditte Neess, Niels Tommerup, Anne Sofie Braun Olsen, Anne Sabers, Oshrit Ben-David, Mai-Britt Mosbech

Publikováno v: Annals of Clinical and Translational Neurology
Mosbech, M-B, Olsen, A S B, Neess, D, Ben-David, O, Klitten, L L, Larsen, J, Sabers, A, Vissing, J, Nielsen, J E, Hasholt, L, Klein, A D, Tsoory, M M, Hjalgrim, H, Tommerup, N, Futerman, A H, Møller, R S & Færgeman, N J 2014, ' Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy ', Annals of Clinical and Translational Neurology, vol. 1, no. 2, pp. 88-98 . https://doi.org/10.1002/acn3.28

OBJECTIVE: Ceramides are precursors of complex sphingolipids (SLs), which are important for normal functioning of both the developing and mature brain. Altered SL levels have been associated with many neurodegenerative disorders, including epilepsy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5688f1974259109301d2ce82c240092
http://europepmc.org/articles/PMC4212479