Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Oshrat Propheta-Meiran"'
Publikováno v:
The Journal of Immunology. 208:105.39-105.39
Monocytes are innate immune cells that drive the chronicity of various inflammatory diseases, making them an attractive target for therapeutic intervention. Monocyte migration to inflamed tissues involves multiple steps of interaction with the vascul
Newly characterized motile sperm domain-containing protein 2 promotes human breast cancer metastasis
Publikováno v:
International Journal of Cancer. 144:125-135
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide. Breast cancer metastasis results in poor prognosis and increased mortality, but the mechanisms of breast cancer metastasis are yet to b
Publikováno v:
The Journal of Immunology. 198:2125-2132
Binding of chemokines to their cognate receptors on monocytes instigates a cascade of events that directs these cells to migrate to sites of inflammation and cancerous tissues. Although targeting of selected chemokine receptors on monocytes exhibited
Autor:
Oshrat Propheta-Meiran, Boris Feldman, Itzhak Mendel, Niva Yacov, Eyal Breitbart, Pinhas Kafri, Yaniv Salem
Publikováno v:
Clinical and Experimental Immunology
Summary In multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), myeloid cells comprise a major part of the inflammatory infiltrate in the central nervous system (CNS). We previously described that motile sperm domain‐containing p
Publikováno v:
Cancer Research. 80:LB-086
Introduction: We have previously showed that motile sperm domain-containing protein 2 (MOSPD2), is highly expressed in multiple solid tumors and cancer cell lines but has low/undetectable levels in healthy tissues, implying that MOSPD2 can be an effe
Publikováno v:
Cancer Research. 80:5592-5592
Introduction: We have previously identified motile sperm domain-containing protein 2 (MOSPD2) as key regulator of monocyte motility. While MOSPD2 is normally expressed by myeloid cells with low/undetectable levels in healthy tissues, high expression
Newly characterized motile sperm domain-containing protein 2 promotes human breast cancer metastasis
Publikováno v:
International Journal of Cancer
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide. Breast cancer metastasis results in poor prognosis and increased mortality, but the mechanisms of breast cancer metastasis are yet to b
Autor:
Erez Feige, Jacob George, Dror Harats, Omri Polonsky, Eyal Breitbart, Ravit Hait-Darshan, Oshrat Propheta-Meiran, Itzhak Mendel, Anat Shoham, Yaniv Salem, Niva Yacov, Itzhak Levi
Publikováno v:
Atherosclerosis. 229(2):430-439
Objective Monocytes are motile cells which sense inflammatory stimuli and subsequently migrate to sites of inflammation. Key players in host defense, monocytes have nevertheless been implicated as requisite mediators of several chronic inflammatory d
Autor:
Eti Ishai, Itzhak Mendel, Oshrat Propheta-Meiran, Anat Shoham, Erez Feige, Gideon Halperin, Eyal Breitbart
Publikováno v:
Journal of Neuroimmunology. 226:126-135
Oxidized phospholipids (Ox-PLs) are generated in abundance at sites of inflammation. Recent studies have indicated that Ox-PLs may also exhibit anti-inflammatory activities. In this study, we investigated the beneficial effect of VB-201, a pure synth
Autor:
Mally Dori, Anat Nir, Shmuel Tuvia, Daniel N. Taglicht, Mordechai Koskas, Iris Alchanati, Oshrat Propheta-Meiran, Dalit Konforty, Haim Moskowitz, Revital Mandil-Levin, Uwe Tessmer, Iris Alroy, Yuval Reiss, Elanite Caspi-Bachar, Shenhav Cohen, Liora Yaar, Haim Barr, Tsvika Greener, Omri Erez, Alin Sela-Brown, Daphna Gordon, Danny Ben-Avraham, Ulrich S. Schubert, Vivian Bicoviski, Orit Levius
Publikováno v:
Proceedings of the National Academy of Sciences. 102:1478-1483
HIV type 1 (HIV-1) was shown to assemble either at the plasma membrane or in the membrane of late endosomes. Now, we report an essential role for human ubiquitin ligase POSH (Plenty of SH3s; hPOSH), a trans-Golgi network-associated protein, in the ta