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Akademický článek

Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model.

Autor: Bodenlenz M; HEALTH - Institute for Biomedical Research and Technologies, Joanneum Research Forschungsgesellschaft M.B.H, Neue Stiftingtalstrasse 2, 8010, Graz, Austria., Yeoh T; Pfizer Research Technology Center, 1 Portland St, Cambridge, MA, 02139, USA., Berstein G; Pfizer Research Technology Center, 1 Portland St, Cambridge, MA, 02139, USA., Mathew S; Pfizer Research Technology Center, 1 Portland St, Cambridge, MA, 02139, USA. Shibin.Mathew@pfizer.com., Shah J; Pfizer Research Technology Center, 1 Portland St, Cambridge, MA, 02139, USA., Banfield C; Pfizer Research Technology Center, 1 Portland St, Cambridge, MA, 02139, USA., Hollingshead B; Pfizer Research Technology Center, 1 Portland St, Cambridge, MA, 02139, USA., Steyn SJ; Pfizer Research Technology Center, 1 Portland St, Cambridge, MA, 02139, USA., Osgood SM; Pfizer Research Technology Center, 1 Portland St, Cambridge, MA, 02139, USA., Beaumont K; Pfizer Research Technology Center, 1 Portland St, Cambridge, MA, 02139, USA., Kainz S; HEALTH - Institute for Biomedical Research and Technologies, Joanneum Research Forschungsgesellschaft M.B.H, Neue Stiftingtalstrasse 2, 8010, Graz, Austria., Holeček C; HEALTH - Institute for Biomedical Research and Technologies, Joanneum Research Forschungsgesellschaft M.B.H, Neue Stiftingtalstrasse 2, 8010, Graz, Austria., Trausinger G; HEALTH - Institute for Biomedical Research and Technologies, Joanneum Research Forschungsgesellschaft M.B.H, Neue Stiftingtalstrasse 2, 8010, Graz, Austria., Raml R; HEALTH - Institute for Biomedical Research and Technologies, Joanneum Research Forschungsgesellschaft M.B.H, Neue Stiftingtalstrasse 2, 8010, Graz, Austria., Birngruber T; HEALTH - Institute for Biomedical Research and Technologies, Joanneum Research Forschungsgesellschaft M.B.H, Neue Stiftingtalstrasse 2, 8010, Graz, Austria. healthca@joanneum.at.

Publikováno v: Pharmaceutical research [Pharm Res] 2024 Feb; Vol. 41 (2), pp. 223-234. Date of Electronic Publication: 2023 Dec 29.

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Correction: Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model.

Publikováno v: Pharmaceutical research [Pharm Res] 2024 Feb; Vol. 41 (2), pp. 409.

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Akademický článek

The Comparison of Machine Learning and Mechanistic In Vitro-In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance.

Autor: Keefer CE; Translational Modeling and Simulation, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Chang G; Translational Modeling and Simulation, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Di L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Woody NA; Translational Modeling and Simulation, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Tess DA; Translational Modeling and Simulation, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Osgood SM; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Kapinos B; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Racich J; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Carlo AA; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Balesano A; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Ferguson N; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Orozco C; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Zueva L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Luo L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2023 Nov 06; Vol. 20 (11), pp. 5616-5630. Date of Electronic Publication: 2023 Oct 09.

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Akademický článek

Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy.

Autor: Apps R; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA., Kotliarov Y; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA., Cheung F; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA., Han KL; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA., Chen J; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA., Biancotto A; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA., Babyak A; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA., Zhou H; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA., Shi R; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA., Barnhart L; Laboratory of Clinical Immunology and Microbiology., Osgood SM; Laboratory of Clinical Immunology and Microbiology., Belkaid Y; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA.; Metaorganism Immunology Section, Laboratory of Immune System Biology, and., Holland SM; Laboratory of Clinical Immunology and Microbiology., Tsang JS; Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, NIH, Bethesda, Maryland, USA.; Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA., Zerbe CS; Laboratory of Clinical Immunology and Microbiology.

Publikováno v: JCI insight [JCI Insight] 2020 Apr 09; Vol. 5 (7). Date of Electronic Publication: 2020 Apr 09.

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Akademický článek

Prediction of Human Brain Penetration of P-glycoprotein and Breast Cancer Resistance Protein Substrates Using In Vitro Transporter Studies and Animal Models.

Autor: Feng B; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340. Electronic address: bo.feng2@pfizer.com., Doran AC; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340., Di L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340., West MA; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340., Osgood SM; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340., Mancuso JY; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340., Shaffer CL; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Cambridge, Massachusetts 02139., Tremaine L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340., Liras J; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Cambridge, Massachusetts 02139.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2018 Aug; Vol. 107 (8), pp. 2225-2235. Date of Electronic Publication: 2018 Mar 30.

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Akademický článek

PDE5 inhibition improves acquisition processes after learning via a central mechanism.

Autor: Akkerman S; Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European School of Neuroscience (EURON), Maastricht University, Maastricht, The Netherlands., Blokland A; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, European School of Neuroscience (EURON), Maastricht University, Maastricht, The Netherlands., van Goethem NP; Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European School of Neuroscience (EURON), Maastricht University, Maastricht, The Netherlands., Cremers P; Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European School of Neuroscience (EURON), Maastricht University, Maastricht, The Netherlands., Shaffer CL; Department of Pharmacokinetics, Pharmacodynamics and Metabolism, Worldwide Research & Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Osgood SM; Department of Pharmacokinetics, Pharmacodynamics and Metabolism, Worldwide Research & Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA., Steinbusch HW; Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European School of Neuroscience (EURON), Maastricht University, Maastricht, The Netherlands., Prickaerts J; Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European School of Neuroscience (EURON), Maastricht University, Maastricht, The Netherlands. Electronic address: jos.prickaerts@maastrichtuniversity.nl.

Publikováno v: Neuropharmacology [Neuropharmacology] 2015 Oct; Vol. 97, pp. 233-9. Date of Electronic Publication: 2015 May 29.

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