Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Oscar W. Huang"'
Autor:
Kim Newton, Jennie R. Lill, Mark Vasser, Zora Modrusan, Jason DeVoss, Rajkumar Noubade, Oscar W. Huang, Donald S. Kirkpatrick, Vishva M. Dixit, Qui T. Phung, Joshua D. Webster, Andrea G. Cochran, Benjamin Fauber, Justin Lesch, Rongze Lu, Lauri Diehl, Xiaoting Wang, Sascha Rutz, Nobuhiko Kayagaki, Celine Eidenschenk, Wenjun Ouyang
Publikováno v:
Nature. 518:417-421
T-helper type 17 (TH17) cells that produce the cytokines interleukin-17A (IL-17A) and IL-17F are implicated in the pathogenesis of several autoimmune diseases. The differentiation of TH17 cells is regulated by transcription factors such as RORγt, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946d8fa3a5110f2b050b117d822329dd
https://doi.org/10.1038/nature13979
https://doi.org/10.1038/nature13979
Autor:
Oscar W. Huang, Andrea G. Cochran
Publikováno v:
Current Opinion in Structural Biology. 23:806-811
Deubiquitinases (DUBs) are proteolytic enzymes whose function is to oppose the process of the conjugation of ubiquitin to a specific substrate. This task is accomplished through an enzymatic cascade involving E1, E2, and E3 enzymes, which collectivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105f1ece11c9faa4431205d5ff2ec483
https://doi.org/10.1016/j.sbi.2013.07.012
https://doi.org/10.1016/j.sbi.2013.07.012
Autor:
Yongyun Wang, Yingjie Li, James E. Audia, F. Anthony Romero, Zhongguo Chen, Alexander M. Taylor, Robert J. Sims, Nico Cantone, Wenfeng Liu, Eneida Pardo, Alexandre Côté, Richard Pastor, Michael C. Hewitt, Steven Magnuson, Jeremy Murray, Steve Bellon, Richard T. Cummings, Jian Wang, Brian K. Albrecht, Hariharan Jayaram, Maureen Beresini, Leslie A. Dakin, Susan Kaufman, Henry Lu, Terry Crawford, Laura Zawadzke, Vickie Tsui, Xiaoqin Zhu, Gladys de Leon Boenig, Xiaoyu Zhu, Christopher G. Nasveschuk, Fen Yan, Yves Leblanc, Jiangpeng Liao, Andrew R. Conery, Zhaowu Xu, E. Megan Flynn, James R. Kiefer, Andrea G. Cochran, Dong Yu, Oscar W. Huang, Jeremy W. Setser, Tommy Lai, Patricia J. Keller
Publikováno v:
ACS medicinal chemistry letters. 7(5)
CBP and EP300 are highly homologous, bromodomain-containing transcription coactivators involved in numerous cellular pathways relevant to oncology. As part of our effort to explore the potential therapeutic implications of selectively targeting bromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20779145f328a160a3abf779659b7000
https://pubmed.ncbi.nlm.nih.gov/27190605
https://pubmed.ncbi.nlm.nih.gov/27190605
Autor:
Bing-Yan Zhu, Andrea G. Cochran, Carter Fields, Oscar W. Huang, Elaine Krueger, Tracy Kleinheinz, Thomas Hunsaker, Jun Liang, Thomas E. Rawson, Jennafer Dotson, Rebecca Pulk, Leslie Walker, John Moffat, Mark Ultsch, Dan Burdick, Birong Zhang, Christian Wiesmann, Ignacio Aliagas-Martin, Gail Lewis Phillips, Laura Corson, Jason Drummond
Publikováno v:
Journal of Medicinal Chemistry. 52:3300-3307
The two major Aurora kinases carry out critical functions at distinct mitotic stages. Selective inhibitors of these kinases, as well as pan-Aurora inhibitors, show antitumor efficacy and are now under clinical investigation. However, the ATP-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67c9e8fdcad506bd5ad91253e284d85
https://doi.org/10.1021/jm9000314
https://doi.org/10.1021/jm9000314
Autor:
E. Megan Flynn, Mariano Oppikofer, Steve Bellon, Florence Poy, Yong Tang, Oscar W. Huang, Andrea G. Cochran
Publikováno v:
Structure (London, England : 1993). 23(10)
SummaryBromodomains are epigenetic readers that are recruited to acetyllysine residues in histone tails. Recent studies have identified non-acetyl acyllysine modifications, raising the possibility that these might be read by bromodomains. Profiling t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70b95bcd3c68b7d693ff692992c55ab
https://pubmed.ncbi.nlm.nih.gov/26365797
https://pubmed.ncbi.nlm.nih.gov/26365797
Publikováno v:
Nature communications. 6
Polycomb repressive complex 1 (PRC1) is required for ubiquitination of histone H2A lysine 119, an epigenetic mark associated with repression of genes important in developmental regulation. The E3 ligase activity of PRC1 resides in the RING1A/B subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83afa2437ddf958c9eaaec682b3e67bb
https://pubmed.ncbi.nlm.nih.gov/26151332
https://pubmed.ncbi.nlm.nih.gov/26151332
Autor:
Ignacio Aliagas-Martin, Dan Burdick, Laura Corson, Jennafer Dotson, Jason Drummond, Carter Fields, Oscar W. Huang, Thomas Hunsaker, Tracy Kleinheinz, Elaine Krueger, Jun Liang, John Moffat, Gail Phillips, Rebecca Pulk, Thomas E. Rawson, Mark Ultsch, Leslie Walker, Christian Wiesmann, Birong Zhang, Bing-Yan Zhu
Publikováno v:
Journal of Medicinal Chemistry; May2009, Vol. 52 Issue 10, p3300-3307, 8p