Photobinding of triflusal to human serum albumin investigated by fluorescence, proteomic analysis, and computational studies

Autor: Miguel A. Miranda, Oscar Molins-Molina, Raúl Pérez-Ruiz, Emilio Lence, Concepción González-Bello, M. Consuelo Jiménez

Publikováno v: Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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Frontiers in Pharmacology
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Digital.CSIC. Repositorio Institucional del CSIC
Frontiers in Pharmacology, Vol 10 (2019)

[EN] Triflusal is a platelet antiaggregant employed for the treatment and prevention of thromboembolic diseases. After administration, it is biotransformed into its active metabolite, the 2-hydroxy-4-trifluoromethylbenzoic acid (HTB). We present here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb343397da4d10599a55ce252cbba45
http://hdl.handle.net/10347/21313

Photogeneration of Quinone Methides as Latent Electrophiles for Lysine Targeting

Autor: Oscar Molins-Molina, Concepción González-Bello, Miguel A. Miranda, Emilio Lence, M. Consuelo Jiménez, Raúl Pérez-Ruiz

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname

[EN] Latent electrophiles are nowadays very attractive chemical entities for drug discovery, as they are unreactive unless activated upon binding with the specific target. In this work, the utility of 4-trifluoromethyl phenols as precursors of latent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d495946acb134f8378284885e3cde856
https://pubmed.ncbi.nlm.nih.gov/30274513

Singlet oxygen production and in vitro phototoxicity studies on fenofibrate, mycophenolate mofetil, trifusal, and their active metabolites.

Autor: Molins ‐ Molina, Oscar¹, Bresolí ‐ Obach, Roger², Garcia ‐ Lainez, Guillermo³, Andreu, Inmaculada³, Nonell, Santi², Miranda, Miguel A.¹ mmiranda@qim.upv.es, Jiménez, M. Consuelo¹ mcjimene@qim.upv.es

Publikováno v: Journal of Physical Organic Chemistry. Sep2017, Vol. 30 Issue 9, pn/a-N.PAG. 7p.