Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Oscar Mario Saavedra"'
Autor:
Millan Mark, Stephen Hanessian, Oscar Mario Saavedra, Jean-Claude Ortuno, Delphine Dupuis, Arnaud Gohier, Clotilde Mannoury la Cour, Anne Rojas, Dominique Brossard, Delphine Karila
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:38-52
All clinically-used antipsychotics display similar affinity for both D2 (D2R) and D3 (D3R) receptors, and they likewise act as 5-HT2A receptor antagonists. They provide therapeutic benefit for positive symptoms, but no marked or consistent improvemen
Autor:
Stephen Hanessian, Terry K. Smith, Juan Pablo Maianti, Oscar Mario Saavedra, Hiroki Kanazawa, Simon A. Young, Jiro Kondo, Luis Izquierdo
This work was supported by Grant‐in‐Aid for Young Scientists (B) (No. 26860025) and Grant‐in‐Aid for Scientific Research (C) (No. 17K08248) from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), and partially s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28a21748e75106c55f8daae7ae73d91
https://hdl.handle.net/10023/17705
https://hdl.handle.net/10023/17705
Autor:
Arnaud Le Tiran, Gaëtan Maertens, Stephen Hanessian, Esat Öney, Sofiane Hocine, Bertrand Goument, Vito Vece, Oscar Mario Saavedra, Miguel A. Vilchis Reyes, Philippe Gloanec, Olivier Mirguet
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(15)
We have developed versatile methods toward the synthesis of a variety of piperidine/piperazine bridged isosteres of pridopidine. The compounds were assessed against the D2 receptor in agonist and antagonist modes and against the D4 receptor in agonis
Autor:
Rowena D. Matias, Stephen Hanessian, Jiro Kondo, Paola Dozzo, Miguel Vilchis-Reyes, A. Serio, Juan Pablo Maianti, Oscar Mario Saavedra, Hiroki Kanazawa
Publikováno v:
Chem. Sci.. 5:4621-4632
This study reports the synthesis, antibacterial evaluation and nature of fluorine–rRNA contacts revealed by an X-ray co-crystal structure of a series of 4′-deoxy-4′-fluoro B-neomycin analogs. 4′-Deoxyfluorination improves the inhibition profi
Publikováno v:
MedChemComm. 5:1166-1171
The syntheses of 4′-deoxy-4′-fluoro neamine and 4′-deoxy-4′-fluoro 4′-epi neamine from the readily available neamine and paromamine are described. Different approaches for the introduction of fluorine such as the use of DAST, sulfonic ester
SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes
Autor:
Stephen William Claridge, Daniel Delorme, Ljubomir Isakovic, David B. Llewellyn, Franck Raeppel, A. Robert MacLeod, Jeffrey M. Besterman, Amal Wahhab, Norman Beaulieu, Arkadii Vaisburg, Lijie Zhan, Jubrail Rahil, Oscar Mario Saavedra, Nadine Elowe, Naomy Bernstein, Andrea J. Petschner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2747-2751
The inhibitory activity of base-modified SAH analogues and the specificity of inhibiting human DNMT1 and DNMT3b2 enzymes was explored. The 6-amino group was essential while the 7-N of the adenine ring of SAH could be replaced by CH- without loss of a
Autor:
Annie Barsalou, Normand Beaulieu, Marja Dubay, Naomy Bernstein, Jeff Gillespie, Marie-France Robert, Jubrail Rahil, Isabelle Dupont, Ian Chute, Sylvain Lefebvre, Marie-Claude Granger, Hannah Nguyen, Oscar Mario Saavedra, James Wang, Jeffrey M. Besterman, Serge Gravel, Amal Wahhab, Lijie Zhan, Arkadii Vaisburg, Roussen Pascal, Carole Beaulieu, Zhiyun Jin, Franck Raeppel, Robert Deziel, David B. Llewellyn, A. Robert MacLeod, Stephen William Claridge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2793-2798
A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC50 values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against
Autor:
Stephen Hanessian, Reinhold Oehrlein, Oscar Mario Saavedra, Vincent Mascitti, Wolfgang Marterer, Ching-Pong Mak
Publikováno v:
Tetrahedron. 57:3267-3280
Synthetic protocols are presented for the elaboration of Galα1→3GalOR and Galα1→3Galβ1→4GlcNAcOR di- and trisaccharides that use a common Gal donor/acceptor unit, and are potentially adaptable to scale-up.
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:439-442
A set of O -substituted aryl β- d -glucopyranosides were prepared and found to have inhibitory activity on the growth of two carcinona cell lines.
Autor:
Reinhold Oehrlein, Stephen Hanessian, Wolfgang Marterer, Ching-Pong Mak, Oscar Mario Saavedra, Vincent Mascitti
Publikováno v:
ChemInform. 32