Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Oscar M Bautista-Aguilera"'
Autor:
Katrin M. Krebs, Eva M. Pfeil, Katharina Simon, Manuel Grundmann, Felix Häberlein, Oscar M. Bautista-Aguilera, Michael Gütschow, C. David Weaver, Bernd K. Fleischmann, Evi Kostenis
Publikováno v:
ACS Omega, Vol 3, Iss 11, Pp 14814-14823 (2018)
Externí odkaz:
https://doaj.org/article/cf66ec141f544b888b152e97640163db
Autor:
Fakher Chabchoub, Oscar M. Bautista-Aguilera, Isabel Iriepa, José Marco-Contelles, Daniel Diez-Iriepa, Lhassane Ismaili, Marta Pérez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Herein we have reviewed our recent developments for the identification of new tacrine analogues for Alzheimer's disease (AD) therapy. Tacrine, the first cholinesterase inhibitor approved for AD treatment, did not stop the progression of AD, producing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2360156a37a400afbacf933377133ae6
https://doi.org/10.1002/tcr.202000107
https://doi.org/10.1002/tcr.202000107
Autor:
Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
Molecules, Vol 21, Iss 5, p 634 (2016)
We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixe
Externí odkaz:
https://doaj.org/article/275dbed00fe84937878fb5586f6d45ed
Autor:
Lhassane Ismaili, Fakher Chabchoub, Isabel Iriepa, José Marco-Contelles, Irene Pachón-Angona, Daniel Diez-Iriepa, Lazhar Zribi, Oscar M. Bautista-Aguilera
Publikováno v:
Molecules
Molecules, Vol 25, Iss 3190, p 3190 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
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Molecules, Vol 25, Iss 3190, p 3190 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Alzheimer's disease (AD) is multifactorial disease characterized by the accumulation of abnormal extracellular deposits of amyloid-beta (Aβ) peptide, and intracellular neurofibrillary tangles (NFTs), along with dramatic neuronal death and decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4beee74d77a3a12591cfb1a34e5c21
https://pubmed.ncbi.nlm.nih.gov/32668671
https://pubmed.ncbi.nlm.nih.gov/32668671
Autor:
Tatiana Natali Vetman, Maria Angeles Martinez-Grau, Monika Schmidt, Francisco López-Muñoz, Rudolf Andrys, Kamil Musilek, Oscar M. Bautista-Aguilera, Christopher David Beadle, Isabel Iriepa, Lhassane Ismaili, Bernard Refouvelet, Mourad Chioua, José Marco-Contelles, Petr Bzonek
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3913, p 3913 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 3913, p 3913 (2020)
In this communication, wereport the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (QN1-19) and 13 dihydroquinolinones (DQN1-13) designed as potential multitarget small molecules (MSM) for Alzheimer¿s diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e26b782fb3da0d0005c6d7c16e1605f
https://pubmed.ncbi.nlm.nih.gov/32486316
https://pubmed.ncbi.nlm.nih.gov/32486316
Autor:
Michael Gütschow, Eva Marie Pfeil, Katharina Simon, Manuel Grundmann, Oscar M Bautista-Aguilera, C. David Weaver, Felix Häberlein, Katrin M Krebs, Evi Kostenis, Bernd K. Fleischmann
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 11, Pp 14814-14823 (2018)
ACS Omega, Vol 3, Iss 11, Pp 14814-14823 (2018)
Dynamic mass redistribution (DMR) and cellular dielectric spectroscopy (CDS) are label-free biosensor technologies that capture real-time integrated cellular responses upon exposure to extra- and intracellular stimuli. They register signaling routes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dae0fb6ee7eee303c5fb0eda41c323a
http://europepmc.org/articles/PMC6289404
http://europepmc.org/articles/PMC6289404
Autor:
Johannes Stephan Schwed, Víctor Farré-Alins, Mourad Chioua, Pierre‐Louis Joffrin, José Marco-Contelles, Ondřej Soukup, Ignacio Moraleda, Jana Janockova, Lena Kalinowsky, Rona R. Ramsay, Javier Egea, Isabel Iriepa, Oscar M. Bautista-Aguilera, Alejandra Palomino-Antolín, Stefanie Hagenow, Lhassane Ismaili, Ewgenij Proschak, Alejandro Romero Martínez, María Luisa Jimeno, Holger Stark, Francisco López-Muñoz
Publikováno v:
Angewandte Chemie. 129:12939-12943
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b15b6e1b22732aad26729afdf979b372
https://doi.org/10.1002/ange.201706072
https://doi.org/10.1002/ange.201706072
Autor:
Oscar M. Bautista-Aguilera, Mohammad A. Khasawneh, Ismail A. El-Haty, Matilde Yáñez, Grzegorz Satała, Andrzej J. Bojarski, Lhassane Ismaili, Abdelouahid Samadi, José Marco-Contelles, Haythem A. Saadeh, Jordi Mestres
Publikováno v:
ChemistrySelect. 2:3854-3859
We describe here the synthesis, antioxidant capacity, and biological activities on MAO, ChE, and selected GPCRs, of novel 1-(2,5-dimethoxybenzyl)-4-arylpiperazines 1–10, as well as known N-(2-(2-methyl-5-nitro-1H-imidazol-1-yl))-2-(4-arylpiperazin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89ed6c6a91d3cc2bff4086adfbb6aa4c
https://doi.org/10.1002/slct.201700397
https://doi.org/10.1002/slct.201700397
Autor:
José Marco-Contelles, Mourad Chioua, Eva Ramos, Gniewomir Latacz, Izabella Góral, Águeda González-Rodríguez, Oscar M. Bautista-Aguilera, Víctor Farré Alins, Natalia Szałaj, Adam Bucki, Francisco López-Muñoz, Alejandro Romero, Anna Więckowska, Javier Egea, Katarzyna Kieć-Kononowicz
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
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ACS Chemical Neuroscience
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ACS Chemical Neuroscience
Herein we report in vitro metabolic stability in human liver microsomes (HLMs), interactions with cytochrome P450 isoenzymes (CYP3A4, CYP2D6, and CYP2C9), and cytotoxicity analyses on HEK-293, HepG2, Huh7, and WTIIB cell lines of our most recent mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa85a307aedfd9889b82ebe41f34bc9
https://ruj.uj.edu.pl/xmlui/handle/item/264594
https://ruj.uj.edu.pl/xmlui/handle/item/264594
Autor:
José Marco-Contelles, Isabel Iriepa, Eduarda Behenck Medeiros, Josiane Budni, Winnie Deuther-Conrad, Oscar M. Bautista-Aguilera, Francisco López-Muñoz, Francielle Mina, Jose-Manuel Entrena, Ignacio Moraleda
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Contilisant, a permeable, antioxidant, and neuroprotectant agent, showing high nM affinity at H3R and excellent inhibition of the monoamine oxidases and cholinesterases, is an affine and selective S1R agonist in the nanomolar range, based on the bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc72a09f425c0d8ea23874e6eba1b7d4
http://hdl.handle.net/10261/178246
http://hdl.handle.net/10261/178246