Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Oscar Franzen"'
Autor:
Lijiang Ma, Nicole S Bryce, Adam W Turner, Antonio F Di Narzo, Karishma Rahman, Yang Xu, Raili Ermel, Katyayani Sukhavasi, Valentina d'Escamard, Nirupama Chandel, Bhargavi V'Gangula, Kathryn Wolhuter, Daniella Kadian-Dodov, Oscar Franzen, Arno Ruusalepp, Ke Hao, Clint L Miller, Johan L M Björkegren, Jason C Kovacic
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010261 (2022)
Genome wide association studies (GWAS) have identified thousands of single nucleotide polymorphisms (SNPs) associated with the risk of common disorders. However, since the large majority of these risk SNPs reside outside gene-coding regions, GWAS gen
Externí odkaz:
https://doaj.org/article/8f50972152a349d08f4369b9b5980542
Autor:
Ariella T. Cohain, William T. Barrington, Daniel M. Jordan, Noam D. Beckmann, Carmen A. Argmann, Sander M. Houten, Alexander W. Charney, Raili Ermel, Katyayani Sukhavasi, Oscar Franzen, Simon Koplev, Carl Whatling, Gillian M. Belbin, Jialiang Yang, Ke Hao, Eimear E. Kenny, Zhidong Tu, Jun Zhu, Li-Ming Gan, Ron Do, Chiara Giannarelli, Jason C. Kovacic, Arno Ruusalepp, Aldons J. Lusis, Johan L. M. Bjorkegren, Eric E. Schadt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Some cholesterol-lowering drugs can increase the risk of type 2 diabetes, but the mechanism behind this is not fully understood. Here the authors show that there is a single genetic regulatory module that influences both cholesterol levels and glucos
Externí odkaz:
https://doaj.org/article/0c2afd1828064aad921b2b15f3e5c1e2
Autor:
Zhidong Tu, Ariella Cohain, Jason C. Kovacic, Arno Ruusalepp, Aldons J. Lusis, Jun Zhu, Katyayani Sukhavasi, Raili Ermel, Daniel M. Jordan, Li-Ming Gan, Jialiang Yang, Ke Hao, Carmen Argmann, Ron Do, Eimear E. Kenny, Sander M. Houten, Chiara Giannarelli, William T. Barrington, Johan L.M. Björkegren, Noam D. Beckmann, Eric E. Schadt, Simon Koplev, Gillian M. Belbin, Oscar Franzen, Carl Whatling, Alexander W. Charney
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Elevated plasma cholesterol and type 2 diabetes (T2D) are associated with coronary artery disease (CAD). Individuals treated with cholesterol-lowering statins have increased T2D risk, while individuals with hypercholesterolemia have reduced T2D risk.
Autor:
Zeyneb Kurt, Jenny Cheng, Rio Barrere-Cain, Caden N McQuillen, Zara Saleem, Neil Hsu, Nuoya Jiang, Calvin Pan, Oscar Franzén, Simon Koplev, Susanna Wang, Johan Björkegren, Aldons J Lusis, Montgomery Blencowe, Xia Yang
Publikováno v:
eLife, Vol 12 (2023)
Mouse models have been used extensively to study human coronary artery disease (CAD) or atherosclerosis and to test therapeutic targets. However, whether mouse and human share similar genetic factors and pathogenic mechanisms of atherosclerosis has n
Externí odkaz:
https://doaj.org/article/e87fc1a00ff440dc9b28b69b90ccd82d
Autor:
Ke Hao, Shouneng Peng, Xiaobin Wang, Antonio Fabio Di Narzo, Arno Ruusalepp, Johan L.M. Björkegren, Jason C. Kovacic, Xiumei Hong, Zhongyang Zhang, Oscar Franzen, Haoxiang Cheng
Publikováno v:
Nucleic Acids Research
The associations between diseases/traits and copy number variants (CNVs) have not been systematically investigated in genome-wide association studies (GWASs), primarily due to a lack of robust and accurate tools for CNV genotyping. Herein, we propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e011a94888bef7ee802f3bba21817989
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/3d08ea275a9e45289bd802aa0918261a
Publikováno v:
eLife, Vol 10 (2021)
Mosquito immune cells, known as hemocytes, are integral to cellular and humoral responses that limit pathogen survival and mediate immune priming. However, without reliable cell markers and genetic tools, studies of mosquito immune cells have been li
Externí odkaz:
https://doaj.org/article/cd5c5fb69f8b42098d345e7a04fa2af2
Autor:
Benjamin S. Glicksberg, Letizia Amadori, Nicholas K. Akers, Katyayani Sukhavasi, Oscar Franzén, Li Li, Gillian M. Belbin, Kristin L. Akers, Khader Shameer, Marcus A. Badgeley, Kipp W. Johnson, Ben Readhead, Bruce J. Darrow, Eimear E. Kenny, Christer Betsholtz, Raili Ermel, Josefin Skogsberg, Arno Ruusalepp, Eric E. Schadt, Joel T. Dudley, Hongxia Ren, Jason C. Kovacic, Chiara Giannarelli, Shuyu D. Li, Johan L. M. Björkegren, Rong Chen
Publikováno v:
BMC Medical Genomics, Vol 12, Iss S6, Pp 1-16 (2019)
Abstract Background Genetic loss-of-function variants (LoFs) associated with disease traits are increasingly recognized as critical evidence for the selection of therapeutic targets. We integrated the analysis of genetic and clinical data from 10,511
Externí odkaz:
https://doaj.org/article/a76b99477ddb49caaac1147906552dfc
Autor:
Nora Franceschini, Claudia Giambartolomei, Paul S. de Vries, Chris Finan, Joshua C. Bis, Rachael P. Huntley, Ruth C. Lovering, Salman M. Tajuddin, Thomas W. Winkler, Misa Graff, Maryam Kavousi, Caroline Dale, Albert V. Smith, Edith Hofer, Elisabeth M. van Leeuwen, Ilja M. Nolte, Lingyi Lu, Markus Scholz, Muralidharan Sargurupremraj, Niina Pitkänen, Oscar Franzén, Peter K. Joshi, Raymond Noordam, Riccardo E. Marioni, Shih-Jen Hwang, Solomon K. Musani, Ulf Schminke, Walter Palmas, Aaron Isaacs, Adolfo Correa, Alan B. Zonderman, Albert Hofman, Alexander Teumer, Amanda J. Cox, André G. Uitterlinden, Andrew Wong, Andries J. Smit, Anne B. Newman, Annie Britton, Arno Ruusalepp, Bengt Sennblad, Bo Hedblad, Bogdan Pasaniuc, Brenda W. Penninx, Carl D. Langefeld, Christina L. Wassel, Christophe Tzourio, Cristiano Fava, Damiano Baldassarre, Daniel H. O’Leary, Daniel Teupser, Diana Kuh, Elena Tremoli, Elmo Mannarino, Enzo Grossi, Eric Boerwinkle, Eric E. Schadt, Erik Ingelsson, Fabrizio Veglia, Fernando Rivadeneira, Frank Beutner, Ganesh Chauhan, Gerardo Heiss, Harold Snieder, Harry Campbell, Henry Völzke, Hugh S. Markus, Ian J. Deary, J. Wouter Jukema, Jacqueline de Graaf, Jacqueline Price, Janne Pott, Jemma C. Hopewell, Jingjing Liang, Joachim Thiery, Jorgen Engmann, Karl Gertow, Kenneth Rice, Kent D. Taylor, Klodian Dhana, Lambertus A. L. M. Kiemeney, Lars Lind, Laura M. Raffield, Lenore J. Launer, Lesca M. Holdt, Marcus Dörr, Martin Dichgans, Matthew Traylor, Matthias Sitzer, Meena Kumari, Mika Kivimaki, Mike A. Nalls, Olle Melander, Olli Raitakari, Oscar H. Franco, Oscar L. Rueda-Ochoa, Panos Roussos, Peter H. Whincup, Philippe Amouyel, Philippe Giral, Pramod Anugu, Quenna Wong, Rainer Malik, Rainer Rauramaa, Ralph Burkhardt, Rebecca Hardy, Reinhold Schmidt, Renée de Mutsert, Richard W. Morris, Rona J. Strawbridge, S. Goya Wannamethee, Sara Hägg, Sonia Shah, Stela McLachlan, Stella Trompet, Sudha Seshadri, Sudhir Kurl, Susan R. Heckbert, Susan Ring, Tamara B. Harris, Terho Lehtimäki, Tessel E. Galesloot, Tina Shah, Ulf de Faire, Vincent Plagnol, Wayne D. Rosamond, Wendy Post, Xiaofeng Zhu, Xiaoling Zhang, Xiuqing Guo, Yasaman Saba, MEGASTROKE Consortium, Abbas Dehghan, Adrie Seldenrijk, Alanna C. Morrison, Anders Hamsten, Bruce M. Psaty, Cornelia M. van Duijn, Deborah A. Lawlor, Dennis O. Mook-Kanamori, Donald W. Bowden, Helena Schmidt, James F. Wilson, James G. Wilson, Jerome I. Rotter, Joanna M. Wardlaw, John Deanfield, Julian Halcox, Leo-Pekka Lyytikäinen, Markus Loeffler, Michele K. Evans, Stéphanie Debette, Steve E. Humphries, Uwe Völker, Vilmundur Gudnason, Aroon D. Hingorani, Johan L. M. Björkegren, Juan P. Casas, Christopher J. O’Donnell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Carotid intima-media thickness (cIMT) and plaque are associated with subclinical atherosclerosis and coronary heart disease (CHD). Here, the authors identify and prioritize genetic loci for cIMT and plaque by GWAS and colocalization approaches and fu
Externí odkaz:
https://doaj.org/article/32fac89a43804269804a3e18ff002db4
Autor:
Katherine C. Michelis, Aya Nomura-Kitabayashi, Laura Lecce, Oscar Franzén, Simon Koplev, Yang Xu, Maria Paola Santini, Valentina D'Escamard, Jonathan T.L. Lee, Valentin Fuster, Roger Hajjar, Ramachandra C. Reddy, Joanna Chikwe, Paul Stelzer, Farzan Filsoufi, Allan Stewart, Anelechi Anyanwu, Johan L.M. Björkegren, Jason C. Kovacic
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 242-257 (2018)
Summary: Mesenchymal stem cells (MSCs) reportedly exist in a vascular niche occupying the outer adventitial layer. However, these cells have not been well characterized in vivo in medium- and large-sized arteries in humans, and their potential pathol
Externí odkaz:
https://doaj.org/article/1f2349ca0d1348c4bbc264d6b3932a36