Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Oscar D. Villarreal"'
Autor:
Rongjie Fu, Wei He, Jinzhuang Dou, Oscar D. Villarreal, Ella Bedford, Helen Wang, Connie Hou, Liang Zhang, Yalong Wang, Dacheng Ma, Yiwen Chen, Xue Gao, Martin Depken, Han Xu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The sequence determinants governing CRISPR/Cas9 specificity are not fully understood. Here, the authors devise a high-throughput dual-target synthetic system to explore the sequence features associated with CRISPR/Cas9 off-target effect, reveal a set
Externí odkaz:
https://doaj.org/article/5fc93d0311ad442eb76be261e9de5028
Autor:
Ting Cai, Jessica K. Cinkornpumin, Zhenbao Yu, Oscar D. Villarreal, William A. Pastor, Stéphane Richard
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109337- (2021)
Summary: RNA-binding proteins play important roles in X-linked intellectual disability (XLID). In this study, we investigate the contribution of the XLID-associated RBMX in neuronal differentiation. We show that RBMX-depleted cells exhibit aberrant a
Externí odkaz:
https://doaj.org/article/4b8b56a3a07d49d8994914c2ecc0e07b
Autor:
Wei He, Liang Zhang, Oscar D. Villarreal, Rongjie Fu, Ella Bedford, Jingzhuang Dou, Anish Y. Patel, Mark T. Bedford, Xiaobing Shi, Taiping Chen, Blaine Bartholomew, Han Xu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Tiling-sgRNA designs allow the in situ evaluation of protein domain functions. Here the authors present ProTiler - a computational method to predict CRISPR knockout hyper-sensitive regions, revealing previously unannotated domains.
Externí odkaz:
https://doaj.org/article/8f9bec4646d34e8fa3bf3716402d6050
Autor:
Wei He, Liang Zhang, Oscar D. Villarreal, Rongjie Fu, Ella Bedford, Jingzhuang Dou, Anish Y. Patel, Mark T. Bedford, Xiaobing Shi, Taiping Chen, Blaine Bartholomew, Han Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/c73123d16f894556a2f4a07d0df664e6
Autor:
Claudia Dominici, Oscar D. Villarreal, Junio Dort, Emilie Heckel, Yu Chang Wang, Ioannis Ragoussis, Jean-Sebastien Joyal, Nicolas A. Dumont, Stéphane Richard
In skeletal muscle, muscle stem cells (MuSC) are the main cells responsible for regeneration upon injury. In diseased skeletal muscle, it would be therapeutically advantageous to replace defective MuSCs, or rejuvenate them with drugs to enhance their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ad314c017cb996b2e37a5db365b832
https://doi.org/10.7554/elife.84570.1
https://doi.org/10.7554/elife.84570.1
Publikováno v:
International Journal of Peptide Research and Therapeutics. 27:967-976
Currently bioactive peptides are the main focus in attempts to identify novel angiotensin-converting enzyme inhibitors (ACEIs) for the treatment of hypertension due to their fewer side effects. In the present study we aimed to investigate the antihyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8102232f17a36f596be5480af55926eb
https://doi.org/10.1007/s10989-020-10142-3
https://doi.org/10.1007/s10989-020-10142-3
Autor:
Kylee J. Veazey, Hieu T. Van, Donghang Cheng, Han Xu, Mabel Perez-Oquendo, Mark T. Bedford, Michael R. Green, Oscar D. Villarreal, Sabrina A. Stratton, Guozhen Gao, Yue Lu, Kevin Lin, Margarida A. Santos
Publikováno v:
Leukemia
Somatic mutations affecting CREBBP and EP300 are a hallmark of diffuse large B-cell lymphoma (DLBCL). These mutations are frequently monoallelic, within the histone acetyltransferase (HAT) domain and usually mutually exclusive, suggesting that they m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332978e8280688988d126ac921ba9a5f
https://doi.org/10.1038/s41375-020-0908-8
https://doi.org/10.1038/s41375-020-0908-8
Autor:
Rongjie Fu, Wei He, Jinzhuang Dou, Oscar D. Villarreal, Ella Bedford, Helen Wang, Connie Hou, Liang Zhang, Yalong Wang, Dacheng Ma, Yiwen Chen, Xue Gao, Martin Depken, Han Xu
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Nature Communications, 13(1)
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Nature Communications, 13(1)
The specificity of CRISPR/Cas9 genome editing is largely determined by the sequences of guide RNA (gRNA) and the targeted DNA, yet the sequence-dependent rules underlying off-target effects are not fully understood. To systematically explore the sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3e75f2bc89d7692e7d9fbf7d25547b
https://pubmed.ncbi.nlm.nih.gov/35078987
https://pubmed.ncbi.nlm.nih.gov/35078987
Autor:
Dalia Barsyte-Lovejoy, Oscar D. Villarreal, Magdelena M. Szewczyk, Samuel E. J. Preston, Sonia V. del Rincón, Han Xu, Stéphane Richard, Nivine Srour, Zhenbao Yu, Wilson H. Miller
Despite the success of immune checkpoint inhibitor (ICI) therapy in different cancers, resistance and relapses are frequent. Thus, combination therapies are expected to enhance response rates and overcome resistance to ICIs. Herein, we report that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed8615a1410937773df91f97456bf22a
https://doi.org/10.1101/2021.07.28.454202
https://doi.org/10.1101/2021.07.28.454202
Autor:
Liang Zhang, Taiping Chen, Han Xu, Xiaobing Shi, Mark T. Bedford, Jingzhuang Dou, Blaine Bartholomew, Wei He, Ella Bedford, Rongjie Fu, Anish Y. Patel, Oscar D. Villarreal
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
High-throughput CRISPR-Cas9 knockout screens using a tiling-sgRNA design permit in situ evaluation of protein domain function. Here, to facilitate de novo identification of essential protein domains from such screens, we propose ProTiler, a computati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958765473b97d786bc01ed446442aa01
http://link.springer.com/article/10.1038/s41467-019-12489-8
http://link.springer.com/article/10.1038/s41467-019-12489-8