Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Oscar Cordero-Llana"'
Autor:
Gongyu Shi, Helen Scott, Nur Izzah Farhana Mohamad Azhar, Andriana Gialeli, Benjamin Clennell, Keng Siang Lee, Jenny Hurcombe, Daniel Whitcomb, Richard Coward, Liang-Fong Wong, Oscar Cordero-Llana, James B. Uney
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract We previously reported that kenpaullone, which inhibits GSK-3a/b and CDKs inhibited CCCP mediated mitochondrial depolarisation and augments the mitochondrial network. To investigate the actions of this class of drug further, we compared the
Externí odkaz:
https://doaj.org/article/0a873f3846674100ba0b71629afe0b9b
Autor:
Keng Siang Lee, Benjamin Clennell, Tom G. J. Steward, Andriana Gialeli, Oscar Cordero-Llana, Daniel J. Whitcomb
Publikováno v:
Brain Sciences, Vol 12, Iss 2, p 289 (2022)
Non-invasive focused ultrasound stimulation (FUS) is a non-ionising neuromodulatory technique that employs acoustic energy to acutely and reversibly modulate brain activity of deep-brain structures. It is currently being investigated as a potential n
Externí odkaz:
https://doaj.org/article/c8c4e6a9765846259a5d4a46b2c057fe
Autor:
Sarah Burley, Dayne A. Beccano-Kelly, Kevin Talbot, Oscar Cordero Llana, Richard Wade-Martins
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract A large hexanucleotide repeat expansion in the C9ORF72 gene is the most prevalent cause of amyotrophic lateral sclerosis (ALS). To better understand neuronal dysfunction during ALS progression, we studied motor neuron (MN) cultures derived f
Externí odkaz:
https://doaj.org/article/b6808073b3ad4007bfe5743a128efd85
Autor:
Silvia Salatino, Clare L. M. Kennedy, Karen R. Mifsud, Johannes M. H. M. Reul, Samantha N. Haque, Eshita Sharma, Oscar Cordero Llana, Polina Panchenko, John Broxholme, Simon Engledow, Hannah M Goss, Andriana Gialeli, Emily M. Price, Helen Lockstone
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Nature Communications
Mifsud, K R, Kennedy, C L M, Salatino, S, Sharma, E, Price, E M, Haque, S N, Gialeli, A, Goss, H M, Panchenko, P E, Broxholme, J, Engledow, S, Lockstone, H, Cordero Llana, O & Reul, J M H M 2021, ' Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors ', Nature Communications, vol. 12, no. 1, 4737 . https://doi.org/10.1038/s41467-021-24967-z
Nature Communications
Mifsud, K R, Kennedy, C L M, Salatino, S, Sharma, E, Price, E M, Haque, S N, Gialeli, A, Goss, H M, Panchenko, P E, Broxholme, J, Engledow, S, Lockstone, H, Cordero Llana, O & Reul, J M H M 2021, ' Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors ', Nature Communications, vol. 12, no. 1, 4737 . https://doi.org/10.1038/s41467-021-24967-z
Glucocorticoid hormones (GCs) — acting through hippocampal mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) — are critical to physiological regulation and behavioural adaptation. We conducted genome-wide MR and GR ChIP-seq and
Autor:
Andriana Gialeli, Nicola Buckner, Liang-Fong Wong, Kevin C Kemp, Caroline A Rivers, Nicholas D. Allen, Helen L. Scott, Alastair Wilkins, Gongyu Shi, James B. Uney, Oscar Cordero-Llana
Publikováno v:
Buckner, N, Kemp, K C, Scott, H L, Shi, G, Rivers, C A, Gialeli, A, Wong, L-F, Cordero Llana, O, Allen, N, Wilkins, A & Uney, J B 2020, ' Abnormal scaffold attachment factor 1 expression and localisation in spinocerebellar ataxias and huntington’s chorea ', Brain Pathology . https://doi.org/10.1111/bpa.12872
Brain Pathology
Brain Pathology
SAFB1 is a DNA and RNA binding protein that is highly expressed in the cerebellum and hippocampus and is involved in the processing of coding and non‐coding RNAs, splicing and dendritic function. We analyzed SAFB1 expression in the post‐mortem br
Autor:
Sarah F. McComish, Maeve A. Caldwell, Petros Stathakos, Lucy A. Crompton, Oscar Cordero-Llana, Jon D. Lane
Publikováno v:
Crompton, L A, McComish, S F, Stathakos, P, Cordero Llana, O, Lane, J D & Caldwell, M A 2021, ' Efficient and Scalable Generation of Human Ventral Midbrain Astrocytes from Human-Induced Pluripotent Stem Cells ', Journal of Visualized Experiments, no. 176, e62095 . https://doi.org/10.3791/62095
In Parkinson's disease, progressive dysfunction and degeneration of dopamine neurons in the ventral midbrain cause life-changing symptoms. Neuronal degeneration has diverse causes in Parkinson's, including non-cell autonomous mechanisms mediated by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed4307da2bb4626058bb04a0d151daa
https://research-information.bris.ac.uk/en/publications/23a72534-28f0-4dfa-a3be-e20d24504769
https://research-information.bris.ac.uk/en/publications/23a72534-28f0-4dfa-a3be-e20d24504769
Autor:
Kelly M Hares, Juliana Redondo, Andrew Herman, Helen L. Scott, Clare L Killick-Cole, Kevin C Kemp, Francesca Mills, Susan C Short, Risto A. Kauppinen, Gary Shaw, Alastair Wilkins, Lorena Sueiro Ballesteros, Heiko Wurdak, James B. Uney, Tom Batstone, Harry Bulstrode, William G B Singleton, Tim Brend, Kathreena M Kurian, Oscar Cordero-Llana, Harry R Haynes
Publikováno v:
The Journal of Pathology
Haynes, H R, Scott, H L, Killick-Cole, C L, Shaw, G, Brend, T, Hares, K M, Redondo, J, Kemp, K C, Ballesteros, L S, Herman, A, Cordero-Llana, O, Singleton, W G, Mills, F, Batstone, T, Bulstrode, H, Kauppinen, R A, Wurdak, H, Uney, J B, Short, S C, Wilkins, A & Kurian, K M 2019, ' shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth ', Journal of Pathology, vol. 247, no. 4, pp. 422-434 . https://doi.org/10.1002/path.5201
Haynes, H R, Scott, H L, Killick-Cole, C L, Shaw, G, Brend, T, Hares, K M, Redondo, J, Kemp, K C, Ballesteros, L S, Herman, A, Cordero-Llana, O, Singleton, W G, Mills, F, Batstone, T, Bulstrode, H, Kauppinen, R A, Wurdak, H, Uney, J B, Short, S C, Wilkins, A & Kurian, K M 2019, ' shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth ', Journal of Pathology, vol. 247, no. 4, pp. 422-434 . https://doi.org/10.1002/path.5201
The overall survival for patients with primary glioblastoma is very poor. Glioblastoma contains a subpopulation of glioma stem cells (GSC) that are responsible for tumour initiation, treatment resistance and recurrence. PPARα is a transcription fact
Publikováno v:
Brain Pathology. 27:530-544
Neuroscience and Neurobiology have historically been neuron biased, yet up to 40% of the cells in the brain are astrocytes. These cells are heterogeneous and regionally diverse but universally essential for brain homeostasis. Astrocytes regulate syna
Autor:
Andriana Gialeli, Bryony McPherson, Axel Heep, Robert Spaull, Aled Clayton, James B. Uney, Oscar Cordero-Llana
Publikováno v:
Spaull, R, McPherson, B, Gialeli, A, Clayton, A, Uney, J, Heep, A & Cordero-Llana, Ó 2019, ' Exosomes populate the cerebrospinal fluid of preterm infants with post-haemorrhagic hydrocephalus ', International Journal of Developmental Neuroscience, vol. 73, pp. 59-65 . https://doi.org/10.1016/j.ijdevneu.2019.01.004
Background\ud\udPreterm infants are at risk of germinal matrix haemorrhage-intraventricular haemorrhage (GMH-IVH) which leads to post-haemorrhagic hydrocephalus (PHH) in 30% of infants; this is associated with moderate-severe neurodevelopmental impai
Autor:
Oscar Cordero-Llana, Benjamin C Houghton, Rafael J. Yáñez-Muñoz, James B. Uney, Maeve A. Caldwell, Liang-Fong Wong, Federica Rinaldi, Hannah Taylor
Publikováno v:
Molecular Therapy. 23:244-254
Cerebral Dopamine Neurotrophic Factor (CDNF) and Mesencephalic Astrocyte-derived Neurotrophic factor (MANF) are members of a recently discovered family of neurotrophic factors (NTFs). Here, we used intranigral or intrastriatal lentiviral vector-media