Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Oscar Charles"'
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 8, Pp n/a-n/a (2021)
Abstract Background Thrombotic thrombocytopenic purpura (TTP), caused by a genetic or autoimmune‐driven lack of ADAMTS‐13 activity, leads to high levels of the ultra‐large von Willebrand factor (VWF) multimers produced by endothelial cells, cau
Externí odkaz:
https://doaj.org/article/ef0cc1f1adad48a4aace1a1b914cd230
Autor:
Cristina Venturini, Julia M Colston, Oscar Charles, Timothy Best, Claire Atkinson, Calum Forrest, Charlotte Williams, Kanchan Rao, Austen Worth, Doug Thorburn, Mark Harber, Paul Griffiths, Judith Breuer
Human cytomegalovirus (HCMV) is the most common and most serious opportunistic infection after solid organ (SOT) and haematopoietic stem cell transplantation (HSCT). There is considerable interest in using virus sequence data to investigate and monit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d6be2b920f5c802da6cfffec1b9705e
https://doi.org/10.1101/2022.09.12.22279849
https://doi.org/10.1101/2022.09.12.22279849
Autor:
Charlotte Summers, Adam Abdullahi, Oscar Charles, Benjamin Krishna, Niluka Goonawardane, Steven Kemp, Donna Mallery
The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and is characterised by multiple spike mutations across all spike domains. Here we show that Omicron BA.1 has higher affinity for ACE2 compared to Delta, and confers very significant evasion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c003439782be699cdd969cfbb2d452d6
https://doi.org/10.1101/2021.12.17.473248
https://doi.org/10.1101/2021.12.17.473248
Sequence-weighting methods are commonly employed to account for biases in sequence datasets. We use a weighting scheme which considers the observed distinctiveness of sequences and apply it to calculations of linkage disequilibrium. Each sequence now
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11e997e094ac6e70519e65cbd3330ca7
https://doi.org/10.1101/2021.06.04.447093
https://doi.org/10.1101/2021.06.04.447093
Autor:
Meenakshi Agarwal, Priti Devi, Ravindra K. Gupta, Thomas A. Mellan, Dami A. Collier, Chiara Silacci-Fegni, Anurag Agrawal, Kalaiarasan Ponnusamy, Raju Vaishya, Christian Saliba, Thomas P. Peacock, Dora Pinto, Bo Meng, Leo C. James, Adam Abdullahi, Jie Zhou, Kei Sato, Rajesh Pandey, Joo-Hyeon Lee, Rawlings Datir, Robin Marwal, Samir Bhatt, Partha Chattopadhyay, Jonathan Brown, Jessica Bassi, Niluka Goonawardne, Shantanu Sengupta, Anna Albecka, Mahesh Shanker Dhar, V. S. Radhakrishnan, Petra Mlcochova, Neeraj Goel, Daniela Caputo, Davide Corti, Guido Papa, Ambrish Satwik, Sujeet Kumar Singh, Luca Piccoli, Isao Yoshida, Wendy S. Barclay, Takashi Irie, Seth Flaxman, Oscar Charles, Antranik Mavousian, Swapnil Mishra, Isabella Ferreira, Partha Rakshit, Chand Wattal, Meena Datta, Charles Whittaker, Steven Kemp, William L Hamilton
The SARS-CoV-2 B.1.617.2 (Delta) variant was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B.1.1.7 (Alpha). In vitro, B.1.617.2 is 6-fold less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06894d95313ac03fcf076f4f86ff6ad3
https://doi.org/10.1101/2021.05.08.443253
https://doi.org/10.1101/2021.05.08.443253
Autor:
Iwuiji C, Richard A. Goldstein, John W. Adamson, de Oliveira T, Pillay D, Darren P. Martin, Derache A, Steven Kemp, Ravindra K. Gupta, Okesola N, Oscar Charles, François Dabis, Katya Govender
Viral population dynamics in long term viraemic antiretroviral therapy (ART) treated individuals have not been well characterised. Prolonged virologic failure on 2nd-line protease inhibitor (PI) based ART without emergence of major protease mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0027859d9b71ddbd2a936b231fd9d4
https://doi.org/10.1101/2021.04.09.21254592
https://doi.org/10.1101/2021.04.09.21254592
The prevention and treatment of HCMV infection is based on the utilization of antiviral therapies as HCMV lacks an effective vaccine. The rise of drug resistance is therefore an increasing patient threat. We identified the need for an open source and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec63149bab929c24fee7c3ee9268a6f
https://doi.org/10.1101/2020.05.15.097907
https://doi.org/10.1101/2020.05.15.097907
Autor:
GALLAGHER, OSCAR CHARLES
Publikováno v:
The Journal of Education, 1928 Mar . 107(12), 357-357.
Externí odkaz:
https://www.jstor.org/stable/42836327
Autor:
Sipin Zhu, Ping Sun, Samuel Bennett, Oscar Charlesworth, Renxiang Tan, Xing Peng, Qiang Gu, Omar Kujan, Jiake Xu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Parthenolide (PTL or PAR) was first isolated from Magnolia grandiflora and identified as a small molecule cancer inhibitor. PTL has the chemical structure of C15H20O3 with characteristics of sesquiterpene lactones and exhibits the biological property
Externí odkaz:
https://doaj.org/article/92bec30c1ea04eb7aeceebe835e1be09
Autor:
Sipin Zhu, Xiaoyong Hu, Samuel Bennett, Oscar Charlesworth, Shengnan Qin, Yuliang Mai, Haicheng Dou, Jiake Xu
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Galanin is a neurohormone as well as a neurotransmitter and plays versatile physiological roles for the neuroendocrine axis, such as regulating food intake, insulin level and somatostatin release. It is expressed in the central nervous system, includ
Externí odkaz:
https://doaj.org/article/afbda1dbd71340f2bff90d9f2eb14c26