Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Oscar B. Goodman"'
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background Neoplastic cells proliferate rapidly and obtain requisite building blocks by reprogramming metabolic pathways that favor growth. Previously, we observed that prostate cancer cells uptake and store lipids in the form of lipid dropl
Externí odkaz:
https://doaj.org/article/77485f3226b84c4c9cc7e440c4281e0c
Autor:
Oscar B. Goodman, Olivia S. Chao
Combination index derived from clonogenic assay of prostate cancer cells treated with SAHA and olaparib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbb3663db2ad286f3d0fb66b6ff3dd3
https://doi.org/10.1158/1541-7786.22510764.v1
https://doi.org/10.1158/1541-7786.22510764.v1
Autor:
Oscar B. Goodman, Olivia S. Chao
Supplementary Methods from Synergistic Loss of Prostate Cancer Cell Viability by Coinhibition of HDAC and PARP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691ed0999513d9ad13d32b7b329f6966
https://doi.org/10.1158/1541-7786.22510767
https://doi.org/10.1158/1541-7786.22510767
Autor:
Oscar B. Goodman, Olivia S. Chao
Tumors with BRCA germline mutations are defective in repairing DNA double-strand breaks (DSB) through homologous recombination (HR) pathways, making them sensitive to PARP inhibitors (PARPi). However, BRCA germline mutations are rare in prostate canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d621fa9c88db5952a7d0b1031cb2fa6
https://doi.org/10.1158/1541-7786.c.6539727
https://doi.org/10.1158/1541-7786.c.6539727
Autor:
Oscar B. Goodman, Olivia S. Chao
Scatter dot plot representing the distribution of number of γH2AX foci/cell of DU145 and RWPE-1 cells treated under different treatment conditions. Horizontal bar represent mean γH2AX foci/cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2f1951f705a4791cc6a006a274e794
https://doi.org/10.1158/1541-7786.22510773.v1
https://doi.org/10.1158/1541-7786.22510773.v1
Autor:
Nizar M. Tannir, Keith Orford, Lalith Akella, Hema Parmar, Zhentao Zhang, Yousef Zakharia, Arash Rezazadeh Kalebasty, Petros G. Nikolinakos, Oscar B. Goodman, Benjamin A. Gartrell, Alice C. Fan, Johanna Bendell, Montaser Shaheen, Vijay Patel, Steven McCune, Sandy Liu, Ulka Vaishampayan, Arif Hussain, James J. Hsieh, Ivor Percent, Marc Matrana, Hamid Emamekhoo, Robert Motzer, Chung-Han Lee
Purpose:Glutaminase is a key enzyme, which supports elevated dependency of tumors on glutamine-dependent biosynthesis of metabolic intermediates. Dual targeting of glucose and glutamine metabolism by the mTOR inhibitor everolimus plus the oral glutam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a186504f410b1b44c1a1931aa5a0590
https://doi.org/10.1158/1078-0432.c.6532388
https://doi.org/10.1158/1078-0432.c.6532388
Autor:
Nizar M. Tannir, Keith Orford, Lalith Akella, Hema Parmar, Zhentao Zhang, Yousef Zakharia, Arash Rezazadeh Kalebasty, Petros G. Nikolinakos, Oscar B. Goodman, Benjamin A. Gartrell, Alice C. Fan, Johanna Bendell, Montaser Shaheen, Vijay Patel, Steven McCune, Sandy Liu, Ulka Vaishampayan, Arif Hussain, James J. Hsieh, Ivor Percent, Marc Matrana, Hamid Emamekhoo, Robert Motzer, Chung-Han Lee
Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2715c83537f8cbfd72bcae33f511a58f
https://doi.org/10.1158/1078-0432.22486787
https://doi.org/10.1158/1078-0432.22486787
Autor:
Nizar M. Tannir, Keith Orford, Lalith Akella, Hema Parmar, Zhentao Zhang, Yousef Zakharia, Arash Rezazadeh Kalebasty, Petros G. Nikolinakos, Oscar B. Goodman, Benjamin A. Gartrell, Alice C. Fan, Johanna Bendell, Montaser Shaheen, Vijay Patel, Steven McCune, Sandy Liu, Ulka Vaishampayan, Arif Hussain, James J. Hsieh, Ivor Percent, Marc Matrana, Hamid Emamekhoo, Robert Motzer, Chung-Han Lee
Supplementary Table from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327aa368f9769c6d320925d88254c103
https://doi.org/10.1158/1078-0432.22486784.v1
https://doi.org/10.1158/1078-0432.22486784.v1
Autor:
Johanna C. Bendell, Boris Kin Lin, Sophie Callies, Anna M. Szpurka, Gregory P. Donoho, Volker Wacheck, Wei Zhang, Susan C. Guba, Paul R. Sieber, Neal D. Shore, Costantine Albany, Ian D. Schnadig, David S. Morris, Oscar B. Goodman, Bryan A. Mehlhaff, Jennifer L. Cultrera, Sunil Babu, Ivor J. Percent, Christopher J. Sweeney
Supplementary Figure from Phase Ib/II Study of Enzalutamide with Samotolisib (LY3023414) or Placebo in Patients with Metastatic Castration-Resistant Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224daf568721c80e465b0dae93e74292
https://doi.org/10.1158/1078-0432.22482390.v1
https://doi.org/10.1158/1078-0432.22482390.v1
Autor:
Johanna C. Bendell, Boris Kin Lin, Sophie Callies, Anna M. Szpurka, Gregory P. Donoho, Volker Wacheck, Wei Zhang, Susan C. Guba, Paul R. Sieber, Neal D. Shore, Costantine Albany, Ian D. Schnadig, David S. Morris, Oscar B. Goodman, Bryan A. Mehlhaff, Jennifer L. Cultrera, Sunil Babu, Ivor J. Percent, Christopher J. Sweeney
Purpose:To report efficacy and safety of samotolisib (LY3023414; PI3K/mTOR dual kinase and DNA-dependent protein kinase inhibitor) plus enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) following cancer progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a955fdf62bcabf4dd78a334c5904c2c
https://doi.org/10.1158/1078-0432.c.6530910
https://doi.org/10.1158/1078-0432.c.6530910