Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Oscar Alvizo"'
Publikováno v:
BioTechniques, Vol 42, Iss 1, Pp 31-39 (2007)
Natural evolution has produced an astounding array of proteins that perform the physical and chemical functions required for life on Earth. Although proteins can be reengineered to provide altered or novel functions, the utility of this approach is l
Externí odkaz:
https://doaj.org/article/bb8af15dc3d040e8bf2e1bfd0459c311
Autor:
Mathew Miller, Oscar Alvizo, Chinping Chng, Stephan Jenne, Melissa Mayo, Arpan Mukherjee, Stuart Sundseth, Avinash Chintala, Jonathan Penfield, James Riggins, Xiyun Zhang, Antoinette Sero, Justin Dassie, Neil Leatherbury, Scott Baskerville, Gjalt Huisman
Messenger RNA (mRNA) therapies have recently gained tremendous traction with the approval of mRNA vaccines for the prevention of SARS-CoV-2 infection. However, manufacturing challenges have complicated large scale mRNA production, which is necessary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fbccc1b28684e06bb5292810d6cd422
https://doi.org/10.1101/2022.09.01.506264
https://doi.org/10.1101/2022.09.01.506264
Autor:
Anna Fryszkowska, Chihui An, Oscar Alvizo, Goutami Banerjee, Keith A. Canada, Yang Cao, Duane DeMong, Paul N. Devine, Da Duan, David M. Elgart, Iman Farasat, Donald R. Gauthier, Erin N. Guidry, Xiujuan Jia, Jongrock Kong, Nikki Kruse, Katrina W. Lexa, Alexey A. Makarov, Benjamin F. Mann, Erika M. Milczek, Vesna Mitchell, Jovana Nazor, Claudia Neri, Robert K. Orr, Peter Orth, Eric M. Phillips, James N. Riggins, Wes A. Schafer, Steven M. Silverman, Christopher A. Strulson, Nandhitha Subramanian, Rama Voladri, Hao Yang, Jie Yang, Xiang Yi, Xiyun Zhang, Wendy Zhong
Publikováno v:
Science (New York, N.Y.). 376(6599)
The emergence of new therapeutic modalities requires complementary tools for their efficient syntheses. Availability of methodologies for site-selective modification of biomolecules remains a long-standing challenge, given the inherent complexity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e1c890246ba90b63af46174410e3e6
https://pubmed.ncbi.nlm.nih.gov/35709283
https://pubmed.ncbi.nlm.nih.gov/35709283
Autor:
Charlene Ching, Abigail Bautista, Oscar Alvizo, David Entwistle, Scott J. Novick, Florian Kleinbeck, Thomas Ruch, Dellas Nikki, David Homan, Garcia Ravi David, Thierry Schlama
Publikováno v:
ACS Catalysis. 11:3762-3770
An amine transaminase was engineered for the efficient production of a chiral precursor to sacubitril, (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid, a key component in the blockb...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d257be1ac0d37e4f6d25601725e1981
https://doi.org/10.1021/acscatal.0c05450
https://doi.org/10.1021/acscatal.0c05450
Autor:
Edward C. Sherer, Junyong Jo, Holst M. Halsey, Jack Liang, Niki R. Patel, Agustina Rodriguez-Granillo, Christopher C. Nawrat, Aaron M. Whittaker, Canada Keith A, Margie Borra-Garske, Nicholas M. Marshall, Kevin R. Campos, Anna Fryszkowska, Yingju Xu, Paul N. Devine, Shane T. Grosser, Grant S. Murphy, Jovana Nazor, Matthew D. Truppo, Benjamin F. Mann, Jeffrey C. Moore, Sandra A. Robaire, Gregory Hughes, Scott J. Novick, Da Duan, Jacob Forstater, Joshua N. Kolev, Deeptak Verma, Kevin M. Maloney, Oscar Alvizo, Mark A. Huffman, Li Xiao, Mark McLaughlin, Leo A. Joyce, Hao Yang
Publikováno v:
Science. 366:1255-1259
Maximal efficiency from enzyme cascades Enzymes are highly selective catalysts that can be useful for specific transformations in organic synthesis. Huffman et al. combined designer enzymes in a multistep cascade reaction (see the Perspective by O'Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6857e349911e642ce3747f4ecbdaad7
https://doi.org/10.1126/science.aay8484
https://doi.org/10.1126/science.aay8484
Autor:
John A. McIntosh, Zhijian Liu, Brian M. Andresen, Nastaran Salehi Marzijarani, Jeffrey C. Moore, Nicholas M. Marshall, Margie Borra-Garske, Jennifer V. Obligacion, Patrick S. Fier, Feng Peng, Jacob H. Forstater, Matthew S. Winston, Chihui An, Wonsuk Chang, Jongwon Lim, Mark A. Huffman, Steven P. Miller, Fuh-Rong Tsay, Michael D. Altman, Charles A. Lesburg, Dietrich Steinhuebel, B. Wesley Trotter, Jared N. Cumming, Alan Northrup, Xiaodong Bu, Benjamin F. Mann, Mirlinda Biba, Kaori Hiraga, Grant S. Murphy, Joshua N. Kolev, Amanda Makarewicz, Weilan Pan, Iman Farasat, Rachel S. Bade, Kevin Stone, Da Duan, Oscar Alvizo, Donovan Adpressa, Erik Guetschow, Erik Hoyt, Erik L. Regalado, Steve Castro, Nelo Rivera, Joseph P. Smith, Fengqiang Wang, Alejandro Crespo, Deeptak Verma, Stephanus Axnanda, Zachary E. X. Dance, Paul N. Devine, David Tschaen, Keith A. Canada, Paul G. Bulger, Benjamin D. Sherry, Matthew D. Truppo, Rebecca T. Ruck, Louis-Charles Campeau, David Jonathan Bennett, Guy R. Humphrey, Kevin R. Campos, Matthew L. Maddess
Publikováno v:
Nature. 603(7901)
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this challenge by using enzymes to carry out multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a99659551d71437d1bb960c572370b
https://pubmed.ncbi.nlm.nih.gov/35296845
https://pubmed.ncbi.nlm.nih.gov/35296845
Autor:
Sophie Racine, Oscar Alvizo, David Entwistle, Evan R. Darzi, Neil K. Garg, Maude Giroud, Jacob E. Dander
Publikováno v:
Communications chemistry
Communications Chemistry, Vol 2, Iss 1, Pp 1-9 (2019)
Communications Chemistry, Vol 2, Iss 1, Pp 1-9 (2019)
One-pot reactions that combine non-enzymatic and biocatalytic transformations represent an emerging strategy in chemical synthesis. Some of the most powerful chemoenzymatic methodologies, although uncommon, are those that form a carbon–carbon (C–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc94e395c7f444acb5c25257e59f9d5c
https://pubmed.ncbi.nlm.nih.gov/32042928
https://pubmed.ncbi.nlm.nih.gov/32042928
Autor:
Birgit Kosjek, Oscar Alvizo, Nobuyoshi Yasuda, Mark A. Huffman, John Limanto, Eric R. Ashley, Zhijian Liu, Artis Klapars, Alan M. Hyde, Xiuyan Gu, Guiquan Liu, Yong-Li Zhong, Nicholas J. Agard, Lushi Tan, David M. Tschaen
Publikováno v:
Organic Letters. 18:5888-5891
A scalable and efficient synthesis of the GPR40 agonist MK-8666 was developed from a simple pyridine building block. The key step to set the stereochemistry at two centers relied on an enzymatic dynamic kinetic reduction of an unactivated ketone. Dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1a98b5df619fcaaff680f336038241
https://doi.org/10.1021/acs.orglett.6b02910
https://doi.org/10.1021/acs.orglett.6b02910
Publikováno v:
Protein Science. 21:1029-1041
HIV-1 protease recognizes and cleaves more than 12 different substrates leading to viral maturation. While these substrates share no conserved motif, they are specifically selected for and cleaved by protease during viral life cycle. Drug resistant m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69cff65e850c2dd54092fa06abaf8fb9
https://doi.org/10.1002/pro.2086
https://doi.org/10.1002/pro.2086
Autor:
Richard J. Fox, Jamie A. Bresson, Jack Liang, Oscar Alvizo, Christopher Savile, Luan J. Nguyen, Satish Lakhapatri, James Michael Broering, James Lalonde, Earl O. P. Solis, Sabrina A. Zimmerman, Scott J. Novick, Michael R. Benoit
Carbonic anhydrase (CA) is one of nature’s fastest enzymes and can dramatically improve the economics of carbon capture under demanding environments such as coal-fired power plants. The use of CA to accelerate carbon capture is limited by the enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73350acc198eba6802f7367c5e770c69
https://europepmc.org/articles/PMC4246266/
https://europepmc.org/articles/PMC4246266/