Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Oscar Alvarez‐Garcia"'
Autor:
Hannah Swahn, Jasmin Mertens, Merissa Olmer, Kevin Myers, Tony S. Mondala, Padmaja Natarajan, Steven R. Head, Oscar Alvarez‐Garcia, Martin K. Lotz
Publikováno v:
Advanced Science, Vol 11, Iss 17, Pp n/a-n/a (2024)
Abstract Elucidating how cell populations promote onset and progression of intervertebral disc degeneration (IDD) has the potential to enable more precise therapeutic targeting of cells and mechanisms. Single‐cell RNA‐sequencing (scRNA‐seq) is
Externí odkaz:
https://doaj.org/article/4784fdf5fbf64119b1051a99e8a6f039
Autor:
Yasunari Yamanaka, Mohammad Ali Faghihi, Marco Magistri, Oscar Alvarez-Garcia, Martin Lotz, Claes Wahlestedt
Publikováno v:
Cell Reports, Vol 11, Iss 6, Pp 967-976 (2015)
Long non-coding RNAs (lncRNAs), including natural antisense transcripts (NATs), are expressed more extensively than previously anticipated and have widespread roles in regulating gene expression. Nevertheless, the molecular mechanisms of action of th
Externí odkaz:
https://doaj.org/article/4a6d4a0d9c42406e96fa0885f4b560f6
Autor:
Martin Lotz, Hiroshi Asahara, Kwang-Il Lee, Andrew I. Su, Oscar Alvarez-Garcia, Jihye Baek, Shawn P. Grogan, Darryl D. D'Lima, Ramya Gamini, Yasunari Ikuta, Joe Hasei, Merissa Olmer
Publikováno v:
Sci Transl Med
Meniscus tears common injuries of the knee joint and a major osteoarthritis (OA) risk factor. Knowledge gaps that limit development of therapeutic approaches for meniscus injury and degeneration concern transcription factors that control the meniscus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9cba663c882bddcaf90223f6952158
https://doi.org/10.1126/scitranslmed.aan7967
https://doi.org/10.1126/scitranslmed.aan7967
Autor:
Martin Lotz, Oscar Alvarez-Garcia, Naoki Okubo, Hirofumi Bekki, Katja A. Lamia, Steve A. Kay, Merissa Olmer, Tomas Duffy
Publikováno v:
Osteoarthritis Cartilage
Summary Objectives Abnormal chondrocyte gene expression promotes osteoarthritis (OA) pathogenesis. A previous RNA-sequencing study revealed that circadian rhythm pathway and expression of core clock gene cryptochrome 2 (CRY2) are dysregulated in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d520412ade87ee712d10dd1d57e90ee4
https://europepmc.org/articles/PMC7476803/
https://europepmc.org/articles/PMC7476803/
Autor:
Merissa Olmer, Martin Lotz, Darryl D. D'Lima, Kwang-Il Lee, Shawn P. Grogan, Tokio Matsuzaki, Oscar Alvarez-Garcia, Sungwook Choi
Publikováno v:
Proc Natl Acad Sci U S A
The objective of this study was to examine FoxO expression and FoxO function in meniscus. In menisci from human knee joints with osteoarthritis (OA), FoxO1 and 3 expression were significantly reduced compared with normal menisci from young and old no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d1ddd2a4185216007a6d22e5a94a1d
https://pubmed.ncbi.nlm.nih.gov/31980519
https://pubmed.ncbi.nlm.nih.gov/31980519
Autor:
Andrew I. Su, Martin Lotz, Kathleen M. Fisch, Oscar Alvarez-Garcia, Y. Muramatsu, R. Akagi, Masahiko Saito, James A. Koziol, Ramya Gamini, Takahisa Sasho
Publikováno v:
Osteoarthritis and Cartilage. 26:1531-1538
Summary Objective Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying therapies are not available, novel therapeutic targets need to be discovered and prioritized for their importance in mediating the abnormal phenotype of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bee4db41ea389182afbe391d0254ca
https://doi.org/10.1016/j.joca.2018.07.012
https://doi.org/10.1016/j.joca.2018.07.012
Autor:
Natàlia Reixach, Martin Lotz, Merissa Olmer, Joel N. Buxbaum, Tokio Matsuzaki, Oscar Alvarez-Garcia, Yukio Akasaki
Publikováno v:
Aging Cell
Summary Deposition of amyloid is a common aging-associated phenomenon in several aging-related diseases. Osteoarthritis (OA) is the most prevalent joint disease, and aging is its major risk factor. Transthyretin (TTR) is an amyloidogenic protein that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e3265b4eebd1e17bd8b33540590d00
https://doi.org/10.1111/acel.12665
https://doi.org/10.1111/acel.12665
Autor:
Martin Lotz, Tokio Matsuzaki, Lars Plate, Oscar Alvarez-Garcia, Merissa Olmer, Jeffery W. Kelly
Publikováno v:
Arthritis & Rheumatology. 69:1418-1428
Objective Regulated in development and DNA damage response 1 (REDD1) is an endogenous inhibitor of mechanistic target of rapamycin (mTOR) that regulates cellular stress responses. REDD1 expression is decreased in aged and osteoarthritic (OA) cartilag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08f9b4202d28c2137d78383f1f785b38
https://doi.org/10.1002/art.40104
https://doi.org/10.1002/art.40104
Publikováno v:
Journal of Orthopaedic Research. 35:2682-2691
Aging is a main risk factor for intervertebral disc (IVD) degeneration, the main cause of low back pain. FOXO transcription factors are important regulators of tissue homeostasis and longevity. Here, we determined the expression pattern of FOXO in he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d75f15d2c52a703dc49da2511c2811fd
https://doi.org/10.1002/jor.23583
https://doi.org/10.1002/jor.23583
Publikováno v:
Osteoarthritis and Cartilage. 25:287-296
Summary Objectives Aging is an important osteoarthritis (OA) risk factor and compromised stress defense responses may mediate this risk. The Sestrins (Sesn) promote cell survival under stress conditions and regulate AMP-activated protein kinase (AMPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e197381ae23e1236d2e1b9b6f2ef6b
https://doi.org/10.1016/j.joca.2016.09.017
https://doi.org/10.1016/j.joca.2016.09.017