Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Oscar Alcázar"'
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Kinsley Belle, Tamar Sapir, Fanuel Messaggio, Kevin B. Johnson, Oliver Umland, Darrell Hardin, Dagmar Klein, Ingrid Pérez-Álvarez, Fatima Sadiq, Oscar Alcázar, Luca A. Inverardi, Camillo Ricordi, Peter Buchwald, Christopher A. Fraker, Ricardo L. Pastori, Juan Domínguez-Bendala
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 611-623 (2019)
Summary: The transplantation of human embryonic stem cell (hESC)-derived insulin-producing β cells for the treatment of diabetes is finally approaching the clinical stage. However, even with state-of-the-art differentiation protocols, a significant
Externí odkaz:
https://doaj.org/article/4370bf27b2c441a0890f656127747865
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
As part of our work to develop small-molecule inhibitors (SMIs) of the CD40-CD40L(CD154) costimulatory protein-protein interaction, here, we describe the ability of two of our most promising SMIs, DRI-C21041 and DRI-C21095, to prolong the survival an
Externí odkaz:
https://doaj.org/article/b9934ccfe1794acfa9cccb4774a29d1d
Autor:
Jerry Bonnell, Oscar Alcazar, Brandon Watts, Peter Buchwald, Midhat H. Abdulreda, Mitsunori Ogihara
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 492 (2024)
Background: Type 1 diabetes (T1D) is a devastating autoimmune disease, and its rising prevalence in the United States and around the world presents a critical problem in public health. While some treatment options exist for patients already diagnosed
Externí odkaz:
https://doaj.org/article/ffa67aaa54fc4a30a58171bdc8629ce7
Autor:
Dimitri Van Simaeys, Adriana De La Fuente, Serena Zilio, Alessia Zoso, Victoria Kuznetsova, Oscar Alcazar, Peter Buchwald, Andrea Grilli, Jimmy Caroli, Silvio Bicciato, Paolo Serafini
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Development of probes specific for human β-cells could aid in delivery of therapeutics and monitoring β-cells mass during diabetes progression or islet transplantation. Here the authors identify two RNA aptamers specific for β-cells that allow eff
Externí odkaz:
https://doaj.org/article/13e8929c62214a04a74a270d1400d915
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1444 (2022)
Background: Type 1 diabetes (T1D) is a devastating disease with serious health complications. Early T1D biomarkers that could enable timely detection and prevention before the onset of clinical symptoms are paramount but currently unavailable. Despit
Externí odkaz:
https://doaj.org/article/4ecb4ee4a58340a28d7baccf618cd6ac
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Due to our interest in the chemical space of organic dyes to identify potential small-molecule inhibitors (SMIs) for protein-protein interactions (PPIs), we initiated a screen of such compounds to assess their inhibitory activity against the interact
Externí odkaz:
https://doaj.org/article/c48ac4cd80d64fb8b9f2cb640008beb9
Publikováno v:
Cell Transplantation, Vol 29 (2020)
Standardized islet characterization assays that can provide results in a timely manner are essential for successful islet cell transplantation. A critical component of islet cell quality is β-cell function, and perifusion-based assessments of dynami
Externí odkaz:
https://doaj.org/article/f2cd43bd8da3437d85d1edeac880fabd
Autor:
Oscar Alcazar, Peter Buchwald
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
The detailed characterization and quantification of the kinetics of glucose-stimulated insulin secretion (GSIS) by normal pancreatic islets is of considerable interest for characterizing β-cell dysfunction, assessing the quality of isolated islets,
Externí odkaz:
https://doaj.org/article/c5839ec9e1784e3fb149853aaac1520e
Autor:
Oscar Alcazar, Luis F. Hernandez, Ernesto S. Nakayasu, Carrie D. Nicora, Charles Ansong, Michael J. Muehlbauer, James R. Bain, Ciara J. Myer, Sanjoy K. Bhattacharya, Peter Buchwald, Midhat H. Abdulreda
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 383 (2021)
Background: Biomarkers are crucial for detecting early type-1 diabetes (T1D) and preventing significant β-cell loss before the onset of clinical symptoms. Here, we present proof-of-concept studies to demonstrate the potential for identifying integra
Externí odkaz:
https://doaj.org/article/a4c3d20657e1404a950a8bc96e98a5dd