Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Oscar A MacLean"'
Autor:
Agnieszka M Szemiel, Andres Merits, Richard J Orton, Oscar A MacLean, Rute Maria Pinto, Arthur Wickenhagen, Gauthier Lieber, Matthew L Turnbull, Sainan Wang, Wilhelm Furnon, Nicolas M Suarez, Daniel Mair, Ana da Silva Filipe, Brian J Willett, Sam J Wilson, Arvind H Patel, Emma C Thomson, Massimo Palmarini, Alain Kohl, Meredith E Stewart
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009929 (2021)
Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small molecule antiviral for the treatment of COVID-19 patients. To date, there are no reports identifying SARS-CoV-2 RDV resistance in patients, animal models or in vit
Externí odkaz:
https://doaj.org/article/7d89e76f634d4950a6f0243895093b37
Autor:
Oscar A MacLean, Spyros Lytras, Steven Weaver, Joshua B Singer, Maciej F Boni, Philippe Lemey, Sergei L Kosakovsky Pond, David L Robertson
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001115 (2021)
Virus host shifts are generally associated with novel adaptations to exploit the cells of the new host species optimally. Surprisingly, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has apparently required little to no significant adap
Externí odkaz:
https://doaj.org/article/69d3f0a61330400a8ff75a6037d7b399
Autor:
Arné de Klerk, Phillip Swanepoel, Rentia Lourens, Mpumelelo Zondo, Isaac Abodunran, Spyros Lytras, Oscar A MacLean, David Robertson, Sergei L Kosakovsky Pond, Jordan D Zehr, Venkatesh Kumar, Michael J Stanhope, Gordon Harkins, Ben Murrell, Darren P Martin
Publikováno v:
Virus Evolution. 8
Recombination contributes to the genetic diversity found in coronaviruses and is known to be a prominent mechanism whereby they evolve. It is apparent, both from controlled experiments and in genome sequences sampled from nature, that patterns of rec
Autor:
Darren P. Martin, Spyros Lytras, Alexander G. Lucaci, Wolfgang Maier, Björn Grüning, Stephen D. Shank, Steven Weaver, Oscar A. MacLean, Richard J. Orton, Philippe Lemey, Maciej F. Boni, Houriiyah Tegally, Gordon W. Harkins, Cathrine Scheepers, Jinal N. Bhiman, Josie Everatt, Daniel G. Amoako, James Emmanuel San, Jennifer Giandhari, Alex Sigal, Carolyn Williamson, Nei-yuan Hsiao, Anne von Gottberg, Arne De Klerk, Robert W. Shafer, David L. Robertson, Robert J. Wilkinson, B. Trevor Sewell, Richard Lessells, Anton Nekrutenko, Allison J. Greaney, Tyler N. Starr, Jesse D. Bloom, Ben Murrell, Eduan Wilkinson, Ravindra K. Gupta, Tulio de Oliveira, Sergei L. Kosakovsky Pond
Among the 30 nonsynonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will likel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd9d9cee7a0bc6864e95f20126e07fd
https://lirias.kuleuven.be/handle/20.500.12942/694602
https://lirias.kuleuven.be/handle/20.500.12942/694602
Autor:
Daniel Mair, E. Thomson, Brian J. Willett, Agnieszka M. Szemiel, Oscar A. MacLean, Meredith Stewart, Matthew L. Turnbull, Alain Kohl, Nicolás M. Suárez, Rute Maria Pinto, Richard J. Orton, Wilhelm Furnon, Arvind H. Patel, Sam J. Wilson, Andres Merits, Arthur Wickenhagen, Sainan Wang, Gauthier Lieber, Massimo Palmarini, Ana da Silva Filipe
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009929 (2021)
PLoS Pathogens
Irish Journal of Medical Science
PLoS Pathogens
Irish Journal of Medical Science
Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small molecule antiviral for the treatment of COVID-19 patients. To date, there are no reports identifying SARS-CoV-2 RDV resistance in patients, animal models or in vit
Autor:
Darren P, Martin, Steven, Weaver, Houryiah, Tegally, Emmanuel James, San, Stephen D, Shank, Eduan, Wilkinson, Alexander G, Lucaci, Jennifer, Giandhari, Sureshnee, Naidoo, Yeshnee, Pillay, Lavanya, Singh, Richard J, Lessells, Ravindra K, Gupta, Joel O, Wertheim, Anton, Nekturenko, Ben, Murrell, Gordon W, Harkins, Philippe, Lemey, Oscar A, MacLean, David L, Robertson, Tulio, de Oliveira, Sergei L, Kosakovsky Pond
Publikováno v:
Cell
medRxiv
medRxiv
The independent emergence late in 2020 of the B.1.1.7, B.1.351, and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by ex
Autor:
Andres Merits, Brian J. Willett, Daniel Mair, Oscar A. MacLean, Agnieszka M. Szemiel, Alain Kohl, Meredith Stewart, Matthew L. Turnbull, Richard J. Orton, Massimo Palmarini, Arthur Wickenhagen, Sainan Wang, Arvind H. Patel, Gauthier Lieber, E. Thomson, Rute Maria Pinto, Sam J. Wilson, Ana da Silva Filipe
Remdesivir (RDV) is used widely for COVID-19 patients despite varying results in recent clinical trials. Here, we show how serially passaging SARS-CoV-2 in vitro in the presence of RDV selected for drug-resistant viral populations. We determined that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b3b1e27d7cd7ee1659f76d2ea40b7ca
https://doi.org/10.1101/2021.02.01.429199
https://doi.org/10.1101/2021.02.01.429199
Autor:
Maciej F. Boni, David Robertson, Sergei L Kosakovsky Pond, Joshua B Singer, Steven Weaver, Oscar A. MacLean, Spyros Lytras, Philippe Lemey
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001115 (2021)
PLOS Biology
PLoS Biology
PLOS Biology
PLoS Biology
Virus host shifts are generally associated with novel adaptations to exploit the cells of the new host species optimally. Surprisingly, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has apparently required little to no significant adap
Publikováno v:
Virus Evolution
A recent study by Tang et al. claimed that two major types of severe acute respiratory syndrome-coronavirus-2 (CoV-2) had evolved in the ongoing CoV disease-2019 pandemic and that one of these types was more ‘aggressive’ than the other. Given the
Autor:
Maciej F. Boni, Kosakovsky Pond Sl, Joshua B Singer, Philippe Lemey, David Robertson, Spyros Lytras, Oscar A. MacLean, Steven Weaver
RNA viruses are proficient at switching host species, and evolving adaptations to exploit the new host’s cells efficiently. Surprisingly, SARS-CoV-2 has apparently required no significant adaptation to humans since the start of the COVID-19 pandemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b8aafa0f0307dad1022300d567237d5
https://doi.org/10.1101/2020.05.28.122366
https://doi.org/10.1101/2020.05.28.122366