Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Oscar, Suzuki"'
1
Akademický článek
Evaluation of the performance of a prior tacrolimus population pharmacokinetic kidney transplant model among adult allogeneic hematopoietic stem cell transplant patients
Autor: Jing Zhu, Olivia Campagne, Chad D. Torrice, Gabrielle Flynn, Jordan A. Miller, Tejendra Patel, Oscar Suzuki, Jonathan R. Ptachcinski, Paul M. Armistead, Tim Wiltshire, Donald E. Mager, Daniel L. Weiner, Daniel J. Crona
Publikováno v: Clinical and Translational Science, Vol 14, Iss 3, Pp 908-918 (2021)
Abstract Tacrolimus is a calcineurin inhibitor used to prevent acute graft versus host disease in adult patients receiving allogeneic hematopoietic stem cell transplantation (HCT). Previous population pharmacokinetic (PK) models have been developed i
Externí odkaz: https://doaj.org/article/78542abfcbac4445984b5ea3fbce00e9
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2
Akademický článek
Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants
Autor: Monica High, Hye-Youn Cho, Jacqui Marzec, Tim Wiltshire, Kirsten C. Verhein, Mauricio T. Caballero, Patricio L. Acosta, Jonathan Ciencewicki, Zackary R. McCaw, Lester Kobzik, Laura Miller-DeGraff, Wes Gladwell, David B. Peden, M. Elina Serra, Min Shi, Clarice Weinberg, Oscar Suzuki, Xuting Wang, Douglas A. Bell, Fernando P. Polack, Steven R. Kleeberger
Publikováno v: EBioMedicine, Vol 11, Iss C, Pp 73-84 (2016)
Background: Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility mechanisms remain unclear
Externí odkaz: https://doaj.org/article/75df4081aa8d475baa78bd98275d0285
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3
Evaluation of the performance of a prior tacrolimus population pharmacokinetic kidney transplant model among adult allogeneic hematopoietic stem cell transplant patients
Autor: Gabrielle Flynn, Jonathan R. Ptachcinski, Chad Torrice, Jing Zhu, Donald E. Mager, Olivia Campagne, Jordan A Miller, Daniel Weiner, Tim Wiltshire, Daniel J. Crona, Paul M. Armistead, Tejendra Patel, Oscar Suzuki
Publikováno v: Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 3, Pp 908-918 (2021)
Tacrolimus is a calcineurin inhibitor used to prevent acute graft versus host disease in adult patients receiving allogeneic hematopoietic stem cell transplantation (HCT). Previous population pharmacokinetic (PK) models have been developed in solid o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f58aed3b9e5579917496c0e319bd65
https://doi.org/10.1111/cts.12956
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4
Akademický článek
Implementing Clinical Pharmacogenomics in the Classroom: Student Pharmacist Impressions of an Educational Intervention Including Personal Genotyping
Autor: Amber Frick, Cristina Benton, Oscar Suzuki, Olivia Dong, Rachel Howard, Hijrah El-Sabae, Tim Wiltshire
Publikováno v: Pharmacy, Vol 6, Iss 4, p 115 (2018)
Pharmacogenomics provides a personalized approach to pharmacotherapy by using genetic information to guide drug dosing and selection. However, partly due to lack of education, pharmacogenomic testing has not been fully implemented in clinical practic
Externí odkaz: https://doaj.org/article/b777ff1a5a584ce0ab03dde870226c68
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5
Characterizing the pharmacogenome using molecular inversion probes for targeted next-generation sequencing
Autor: Olivia M. Dong, Tim Wiltshire, Rachel Howard, Oscar Suzuki
Publikováno v: Pharmacogenomics. 20:1005-1020
Aim: This study assesses the technical performance and cost of a targeted next-generation sequencing (NGS) multigene pharmacogenetic (PGx) test. Materials & methods: A genetic test was developed for 21 PGx genes using molecular inversion probes to ge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13923d99fe26873b636800527c01f21
https://doi.org/10.2217/pgs-2019-0057
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6
Influence of Germline Genetics on Tacrolimus Pharmacokinetics and Pharmacodynamics in Allogeneic Hematopoietic Stem Cell Transplant Patients
Autor: James M. Coghill, Tim Wiltshire, J. Ryan Shaw, Paul M. Armistead, Thomas C. Shea, Marcie L. Riches, Chad Torrice, Jordan A Miller, Mehak Aggarwal, Kamakshi V. Rao, William A. Wood, Jing Zhu, Oscar Suzuki, Tatjana Grgic, Margaret R Sketch, John L. Schmitz, Daniel J. Crona, Eric T. Weimer, Tejendra Patel, Benjamin G. Vincent, Katarzyna Jamieson, Maurice Alexander, Jonathan S. Serody, Jonathan R. Ptachcinski
Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences, Vol 21, Iss 3, p 858 (2020)
Tacrolimus exhibits high inter-patient pharmacokinetics (PK) variability, as well as a narrow therapeutic index, and therefore requires therapeutic drug monitoring. Germline mutations in cytochrome P450 isoforms 4 and 5 genes (CYP3A4/5) and the ATP-b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6399bb0da3bbe2203d5023dd0fc930e
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7
Akademický článek
Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival.
Autor: Selina E R Bopp, Vandana Ramachandran, Kerstin Henson, Angelina Luzader, Merle Lindstrom, Muriel Spooner, Brian M Steffy, Oscar Suzuki, Chris Janse, Andrew P Waters, Yingyao Zhou, Tim Wiltshire, Elizabeth A Winzeler
Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10903 (2010)
The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium
Externí odkaz: https://doaj.org/article/390d912ca8ba4896853cae72680b29fb
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8
Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging?
Autor: Farida S. Akhtari, Julie B. Dumond, Alison A. Motsinger-Reif, Jingxian Chen, Michael J. Wagner, Oscar Suzuki, Tim Wiltshire
Publikováno v: Clinical and Translational Science. 11:226-236
Analysis of aging and pharmacogenetics (PGx) on antiretroviral pharmacokinetics (PKs) could inform precision dosing for older human HIV-infected patients. Seventy-four participants receiving either atazanavir/ritonavir (ATV/RTV) or efavirenz (EFV) wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd90996a2566a2128d07eb2303f77e48
https://doi.org/10.1111/cts.12525
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10
Implementing Clinical Pharmacogenomics in the Classroom: Student Pharmacist Impressions of an Educational Intervention Including Personal Genotyping
Autor: Olivia M. Dong, Tim Wiltshire, Cristina S. Benton, Hijrah El-Sabae, Amber Frick, Oscar Suzuki, Rachel Howard
Publikováno v: Pharmacy: Journal of Pharmacy Education and Practice
Pharmacy, Vol 6, Iss 4, p 115 (2018)
Pharmacy
Volume 6
Issue 4
Pharmacogenomics provides a personalized approach to pharmacotherapy by using genetic information to guide drug dosing and selection. However, partly due to lack of education, pharmacogenomic testing has not been fully implemented in clinical practic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcd1b91829ad566ab231f9c80403d5e
https://pubmed.ncbi.nlm.nih.gov/30360487
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