Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Oscar, Campetella"'
Autor:
Benoit Stijlemans, Patrick De Baetselier, Inge Van Molle, Laurence Lecordier, Erika Hendrickx, Ema Romão, Cécile Vincke, Wendy Baetens, Steve Schoonooghe, Gholamreza Hassanzadeh-Ghassabeh, Hannelie Korf, Marie Wallays, Joar E. Pinto Torres, David Perez-Morga, Lea Brys, Oscar Campetella, María S. Leguizamón, Mathieu Claes, Sarah Hendrickx, Dorien Mabille, Guy Caljon, Han Remaut, Kim Roelants, Stefan Magez, Jo A. Van Ginderachter, Carl De Trez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Human African trypanosomiasis or sleeping sickness, caused by the protozoan parasite Trypanosoma brucei, is characterized by the manipulation of the host’s immune response to ensure parasite invasion and persistence. Uncovering key molecul
Externí odkaz:
https://doaj.org/article/246f0d22755a498bb72fe9a96e853695
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e24595- (2024)
Nearly all expression vectors currently available for Trypanosoma cruzi were conceived to produce a single primary transcript containing the genes of interest along with those that confer antibiotic resistance. However, since each messenger RNA (mRNA
Externí odkaz:
https://doaj.org/article/2b472b1b24be44bda04f14e4fb9146fd
Autor:
Martín Somoza, Adriano Bertelli, Cecilia A. Pratto, Ramiro E. Verdun, Oscar Campetella, Juan Mucci
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
Trypanosoma cruzi infection induces a polyclonal B cell proliferative response characterized by maturation to plasma cells, excessive generation of germinal centers, and secretion of parasite-unrelated antibodies. Although traditionally reduced to th
Externí odkaz:
https://doaj.org/article/e393a2339de8468db7bc05188ff2e188
Autor:
Cecilia Arahí Prato, Julieta Carabelli, Valentina Cattaneo, Oscar Campetella, María Virginia Tribulatti
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100204- (2020)
Summary: Galectins are soluble lectins that participate in many physiological and pathological functions. Since they can act extracellularly, the use of the recombinant protein is a recurrent strategy for studying their biological functions. Here, we
Externí odkaz:
https://doaj.org/article/b50a5181e4684aaa9bfe29f83d26b75c
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101278- (2020)
Summary: Galectin-8 (Gal-8) is a mammalian lectin endowed with immunostimulatory ability. In the present work, we demonstrate that Gal-8-glycan interactions on the surface of antigen-presenting cells (APCs) promote antigen binding and internalization
Externí odkaz:
https://doaj.org/article/5b6cf7925a72470a961abf2dd4f7c4ec
Autor:
Cristian Gabriel Beccaria, María Carolina Amezcua Vesely, Facundo Fiocca Vernengo, Ricardo Carlos Gehrau, María Cecilia Ramello, Jimena Tosello Boari, Melisa Gorosito Serrán, Juan Mucci, Eliane Piaggio, Oscar Campetella, Eva Virginia Acosta Rodríguez, Carolina Lucía Montes, Adriana Gruppi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that g
Externí odkaz:
https://doaj.org/article/e56f9c7562ff48e1b8ef2534da1247d2
Autor:
Maite Lobo, Virginia Balouz, Luciano Melli, Giannina Carlevaro, María E Cortina, María de Los Milagros Cámara, Gaspar E Cánepa, Santiago J Carmona, Jaime Altcheh, Oscar Campetella, Andrés E Ciocchini, Fernán Agüero, Juan Mucci, Carlos A Buscaglia
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e0007245 (2019)
BACKGROUND:TolT was originally described as a Trypanosoma cruzi molecule that accumulated on the trypomastigote flagellum bearing similarity to bacterial TolA colicins receptors. Preliminary biochemical studies indicated that TolT resolved in SDS-PAG
Externí odkaz:
https://doaj.org/article/084386b17edb44459ea0f1c8f4f44583
Autor:
Cristina E. Rodríguez, Alicia Jawerbaum, Oscar Campetella, Martin M. Edreira, Romina Higa, María S. Leguizamón, Daniel Musikant
Publikováno v:
Biochimie
Matrix metalloproteinases (MMPs) not only play a relevant role in homeostatic processes but are also involved in several pathological mechanisms associated with infectious diseases. As their clinical relevance in Chagas disease has recently been high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e3d6771d3854c91799de5161c1d174
https://doi.org/10.1016/j.biochi.2021.04.005
https://doi.org/10.1016/j.biochi.2021.04.005
Inactive trans-Sialidase Expression in iTS-null Trypanosoma cruzi Generates Virulent Trypomastigotes
Autor:
Carla A. Pascuale, Juan M. Burgos, Miriam Postan, Andrés B. Lantos, Adriano Bertelli, Oscar Campetella, M. Susana Leguizamón
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Disclosing virulence factors from pathogens is required to better understand the pathogenic mechanisms involved in their interaction with the host. In the case of Trypanosoma cruzi several molecules are associated with virulence. Among them, the tran
Externí odkaz:
https://doaj.org/article/e57613a4a7f3475b9c1eb7758372953c
Autor:
María de Los Milagros Cámara, Gaspar E Cánepa, Andrés B Lantos, Virginia Balouz, Hai Yu, Xi Chen, Oscar Campetella, Juan Mucci, Carlos A Buscaglia
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005856 (2017)
TSSA (Trypomastigote Small Surface Antigen) is an antigenic, adhesion molecule displayed on the surface of Trypanosoma cruzi trypomastigotes. TSSA displays substantial sequence identity to members of the TcMUC gene family, which code for the trypomas
Externí odkaz:
https://doaj.org/article/f0c0c58d5bb349fdbcd0ce3e51f34bfd