Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype

Autor: Beltrán-García J, Osca-Verdegal R, Pérez-Cremades D, Novella S, Hermenegildo C, Pallardó FV, García-Giménez JL

Publikováno v: Journal of Inflammation Research, Vol Volume 15, Pp 4217-4238 (2022)

Jesús Beltrán-García,1– 3 Rebeca Osca-Verdegal,1,3 Daniel Pérez-Cremades,2,3 Susana Novella,2,3 Carlos Hermenegildo,2,3 Federico V Pallardó,1– 3 José Luis García-Giménez1– 3 1Centro de Investigación Biomédica en Red de Enfermedades Ra

Externí odkaz: https://doaj.org/article/d59b290db7524d14a6ed8b6efaa06fa9

DNA Methylation Analysis to Unravel Altered Genetic Pathways Underlying Early Onset and Late Onset Neonatal Sepsis. A Pilot Study

Autor: Lorente-Pozo S, Navarrete P, Garzón MJ, Lara-Cantón I, Beltrán-García J, Osca-Verdegal R, Mena-Mollá S, García-López E, Vento M, Pallardó FV, García-Giménez JL

Publikováno v: Frontiers in Immunology
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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Frontiers in immunology
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

Background: Neonatal sepsis is a systemic condition widely affecting preterm infants and characterized by pro-inflammatory and anti-inflammatory responses. However, its pathophysiology is not yet fully understood. Epigenetics regulates the immune sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::84ec510ac53943bc2fa18d60328f53c0
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15642

Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches

Autor: Beltran-Garcia J, Osca-Verdegal R, Pallardo F, Ferreres J, Rodriguez M, Mulet S, Ferrando-Sanchez C, Carbonell N, Garcia-Gimenez J

Publikováno v: CRITICAL CARE MEDICINE
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Great efforts are being made worldwide to identify the specific clinical characteristics of infected critically ill patients that mediate the associated pathogenesis, including vascular dysfunction, thrombosis, dysregulated inflammation, and respirat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::5359c1882dd098d81e567ddc7da9d9ca
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4736

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

Autor: Beltran-Garcia J, Osca-Verdegal R, Pallardo F, Ferreres J, Rodriguez M, Mulet S, Sanchis-Gomar F, Carbonell N, Garcia-Gimenez J

Publikováno v: ANTIOXIDANTS
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak emerged, countless efforts are being made worldwide to understand the molecular mechanisms underlying the coronavirus disease 2019 (COVID-19) in an attempt to identify th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::48c1ade2bde957943e70e9b404740502
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15040

Epigenetic Regulation in the Pathogenesis of Sjogren Syndrome and Rheumatoid Arthritis

Autor: Ibanez-Cabellos J, Seco-Cervera M, Osca-Verdegal R, Pallardo F, Garcia-Gimenez J

Publikováno v: Frontiers in Genetics
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::e792a6dfdaf981694e80bad0d05453c0
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4097