Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Osamu Shimozato"'
Autor:
Yusuke Mori, Ayaka Takeuchi, Kengo Miyagawa, Hiroyuki Yoda, Hiroaki Soda, Yoshihiro Nabeya, Naoko Watanabe, Toshinori Ozaki, Osamu Shimozato
Publikováno v:
FEBS Open Bio, Vol 11, Iss 5, Pp 1382-1394 (2021)
During the early phase of tumorigenesis, primary malignant cells survive within a low nutrition environment caused by a poorly organized vascular system. Here, we sought to determine the functional significance of CD133 in the survival of cancer cell
Externí odkaz:
https://doaj.org/article/fd8981ba8a1641748a451afe91318dea
Autor:
Yosuke Iwatate, Hajime Yokota, Isamu Hoshino, Fumitaka Ishige, Naoki Kuwayama, Makiko Itami, Yasukuni Mori, Satoshi Chiba, Hidehito Arimitsu, Hiroo Yanagibashi, Wataru Takayama, Takashi Uno, Jason Lin, Yuki Nakamura, Yasutoshi Tatsumi, Osamu Shimozato, Hiroki Nagase
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Transcriptomic analysis of cancer samples helps identify the mechanism and molecular markers of cancer. However, transcriptomic analyses of pancreatic cancer from the Japanese population are lacking. Hence, in this study, we performed RNA sequencing
Externí odkaz:
https://doaj.org/article/531c38c3c0214a17b9031bed43148906
Autor:
Masashi Matsushita, Yusuke Mori, Kyosuke Uchiumi, Takehiro Ogata, Mizuyo Nakamura, Hiroyuki Yoda, Hiroaki Soda, Nobuhiro Takiguchi, Yoshihiro Nabeya, Osamu Shimozato, Toshinori Ozaki
Publikováno v:
FEBS Open Bio, Vol 9, Iss 5, Pp 935-946 (2019)
Receptor‐type protein tyrosine phosphatase κ (PTPRK) is considered to be a candidate tumor suppressor. PTPRK dephosphorylates CD133, which is a stem cell marker; phosphorylated CD133 accelerates xenograft tumor growth of colon cancer cells through
Externí odkaz:
https://doaj.org/article/5dce7d4e79ee46b2909bba714dbb1660
Publikováno v:
Biomolecules, Vol 5, Iss 4, Pp 2854-2876 (2015)
During the lifespan of cells, their genomic DNA is continuously exposed to theendogenous and exogenous DNA insults. Thus, the appropriate cellular response to DNAdamage plays a pivotal role in maintaining genomic integrity and also acts as a molecula
Externí odkaz:
https://doaj.org/article/fa2d2b66123747bcacaeaddcf6045521
Autor:
Takehiro Ogata, Mizuyo Nakamura, Meijie Sang, Hiroyuki Yoda, Kiriko Hiraoka, Danjing Yin, Mexiang Sang, Osamu Shimozato, Toshinori Ozaki
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179884 (2017)
Suberoylanilide hydroxamic acid (SAHA) represents one of the new class of anti-cancer drugs. However, multiple lines of clinical evidence indicate that SAHA might be sometimes ineffective on certain solid tumors including pancreatic cancer. In this s
Externí odkaz:
https://doaj.org/article/baa09445473d44f690347ae8215e726f
Autor:
Boya Zhong, Guangyu Ma, Ayako Sato, Osamu Shimozato, Hongdan Liu, Quanhai Li, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
Interaction of Fas and Fas ligand (FasL) plays an important role in the regulation of immune responses by inducing apoptosis of activated cells; however, a possible role of FasL in DNA vaccination has not been well understood. We examined whether adm
Externí odkaz:
https://doaj.org/article/7dcaed6ba6ba47ef992fc40ad3086d0b
Autor:
Yuchen Sun, Tomomi Furihata, Seiya Ishii, Miki Nagai, Manami Harada, Osamu Shimozato, Takehiko Kamijo, Shinichiro Motohashi, Ichiro Yoshino, Atsuko Kamiichi, Kaoru Kobayashi, Kan Chiba
Publikováno v:
Clinical and Translational Medicine, Vol 3, Iss 1, Pp n/a-n/a (2014)
Abstract Background We have previously identified the cancer‐type organic anion transporting polypeptide 1B3 (Ct‐OATP1B3) mRNA in several human colon and lung cancer tissues. Ct‐OATP1B3 is a variant of the liver‐type OATP1B3 (Lt‐OATP1B3) mR
Externí odkaz:
https://doaj.org/article/2c59aebe4cc3417c8509cb21b5c2b8ee
Autor:
Daisuke Hoshi, Emiri Kita, Yoshiaki Maru, Hiroyuki Kogashi, Yuki Nakamura, Yasutoshi Tatsumi, Osamu Shimozato, Kazuyoshi Nakamura, Kentaro Sudo, Akiko Tsujimoto, Ryo Yokoyama, Atsushi Kato, Tetsuo Ushiku, Masashi Fukayama, Makiko Itami, Taketo Yamaguchi, Yoshitaka Hippo
Publikováno v:
Cancer Science. 114:1165-1179
Acinar cell carcinoma (ACC) of the pancreas is a malignant tumor of the exocrine cell lineage with a poor prognosis. Due to its rare incidence and technical difficulties, few authentic human cell lines are currently available, hampering detailed inve
Autor:
Yosuke Iwatate, Yuki Nakamura, Hiroki Nagase, Yasutoshi Tatsumi, Isamu Hoshino, Makiko Itami, Hajime Yokota, Osamu Shimozato, Naoki Kuwayama, Yasukuni Mori, Fumitaka Ishige, Takashi Uno
Publikováno v:
Cancer Science
Tumor mutational burden (TMB) is gaining attention as a biomarker for responses to immune checkpoint inhibitors in cancer patients. In this study, we evaluated the status of TMB in primary and liver metastatic lesions in patients with colorectal canc
Autor:
Toshinori Tsukanishi, Tsukasa Yonemoto, Hiroto Kamoda, Hideyuki Kinoshita, Takeshi Ishii, Yoko Hagiwara, Osamu Shimozato, Seiji Ohtori
Publikováno v:
Anticancer Research. 41:4947-4955
Background/aim Auranofin (AUR), a thioredoxin reductase (TXNRD) inhibitor, shows anticancer activity against several cancers. This study investigated the effects of AUR on the local progression and pulmonary metastasis of osteosarcoma (OS). Materials