Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Osamu Nakanishi"'
Autor:
Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events
Externí odkaz:
https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
Autor:
Shinsuke Araki, Ryo Dairiki, Yusuke Nakayama, Aiko Murai, Risa Miyashita, Misa Iwatani, Toshiyuki Nomura, Osamu Nakanishi
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116929 (2015)
Accumulating evidence has demonstrated the importance of alternative splicing in various physiological processes, including the development of different diseases. CDC-like kinases (CLKs) and serine-arginine protein kinases (SRPKs) are components of t
Externí odkaz:
https://doaj.org/article/c03c65d55d8948bcbcc348848340aa05
Autor:
Mutai Yosuke, Yoshikazu Fujimori, Fumiya Tanada, Yasuhiko Igawa, Hideaki Hirasawa, Osamu Nakanishi, Naoki Aizawa, Akane Matsuzawa, Takemitsu Hayashi, Jun-ichi Kobayashi
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:239-247
Transient receptor potential (TRP) melastatin 8 (TRPM8) is a temperature-sensing ion channel mainly expressed in primary sensory neurons (Aδ-fibers and C-fibers in the dorsal root ganglion). In this report, we characterized KPR-5714 (N-[(R)-3,3-difl
Autor:
Naoki, Aizawa, Yoshikazu, Fujimori, Osamu, Nakanishi, Takemitsu, Hayashi, Yoshiaki, Goi, Jun-Ichi, Kobayashi, Tomoe, Fujita
Publikováno v:
European journal of pharmacology. 899
Transient receptor potential melastatin 8 (TRPM8) channels may contribute to the pathophysiological bladder afferent hyperactivity, thus a TRPM8 antagonist would be a promising therapeutic target for the bladder hypersensitive disorders including uri
Autor:
Takemitsu Hayashi, Jun-ichi Kobayashi, Tomoe Fujita, Yoshiaki Goi, Naoki Aizawa, Osamu Nakanishi, Yoshikazu Fujimori
Publikováno v:
European Journal of Pharmacology. 899:173995
Transient receptor potential melastatin 8 (TRPM8) channels may contribute to the pathophysiological bladder afferent hyperactivity, thus a TRPM8 antagonist would be a promising therapeutic target for the bladder hypersensitive disorders including uri
Autor:
Yoshikazu Fujimori, Noboru Kamada, Tomonaga Ozawa, Osamu Nakanishi, Tetsuya Ikeda, Tetsuji Ozawa, Hiroo Takeda, Jun-ichi Kobayashi, Hideaki Hirasawa
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:727-742
Transient receptor potential melastatin 8 (TRPM8) is activated by innocuous cold and chemical substances, and antagonists of this channel have been considered to be effective for pain and urinary diseases. N-(3-aminopropyl)-2-{[(3-methylphenyl)methyl
Autor:
Chiaki Handa, Noritaka Furuya, Hideyuki Muranaka, Takashi Miyagi, Kenji Katsuno, Motoyasu Ozawa, Shigeru Yonekubo, Nobuhiko Fushimi, Osamu Nakanishi
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:5895-5910
The estrogen receptor beta (ERβ) selective agonist is considered a promising candidate for the treatment of estrogen deficiency symptoms in ERβ-expressing tissues, without the risk of breast cancer, and multiple classes of compounds have been repor
Autor:
Yasuhiko Igawa, Haruki Kume, Osamu Nakanishi, Jun-ichi Kobayashi, Yukio Homma, Hideaki Hirasawa, Naoki Aizawa, Yoshikazu Fujimori
Publikováno v:
Neurourology and urodynamics. 37(5)
Aims Transient receptor potential melastatin 8 (TRPM8) is proposed to be a promising therapeutic target for hypersensitive bladder disorders. We examined the effects of KPR-2579, a novel selective TRPM8 antagonist, on body temperature and on mechanos
Autor:
Damian Yap, Nao Morishita, Atsushi Nakanishi, Karey Shumansky, Shinsuke Araki, Shoichi Nakao, Satoshi Sasaki, Esther Kong, Ryujiro Hara, Momoko Ohori, Hiroyoshi Toyoshiba, Adrian Wan, Masatoshi Karashima, Mari Ogasawara-Shimizu, Osamu Nakanishi, Hirokazu Tozaki, Christopher S. Hughes, Noriko Uchiyama, S.-W. Grace Cheng, Masaya Sano, Daisuke Morishita, Tomohiro Kawamoto, Tohru Miyazaki, Shinya Tasaki, Jamie Rosner, Tyler Funnell, Sohrab P. Shah, Arusha Oloumi, Toshiyuki Nomura, Samuel Aparicio, Steven McKinney, Yusuke Nakayama, Tomohiro Ohashi, Aiko Murai, Gregg B. Morin, Misa Iwatani
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent RNA processing events remains poorly defined. Here, we explore the connectivity of genomic CD
Autor:
Teppei Sago, Seiji Watanabe, Kentaro Ono, Kiyotoshi Inenaga, Suzuro Hitomi, Shunji Shiiba, Masahito Nunomaki, Mitsuhiro Yoshida, Nozomu Harano, T. Yamamoto, Osamu Nakanishi
Publikováno v:
Journal of Dental Research. 92:335-339
Recent evidence implicates endothelin in nociception, but it is unclear how endothelin activates trigeminal ganglion (TRG) neurons. In the present study, we investigated the expression of the endothelin receptors ETA and ETB and endothelin-induced re