Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Osamu Kotani"'
Autor:
Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki
Publikováno v:
PLoS Pathogens, Vol 20, Iss 3, p e1012091 (2024)
No antiviral drugs currently are available for treatment of infection by hepatitis A virus (HAV), a causative agent of acute hepatitis, a potentially life-threatening disease. Chemical screening of a small-compound library using nanoluciferase-expres
Externí odkaz:
https://doaj.org/article/21dadf4bf2934359b841214f73051e83
Autor:
Yoshihiro Samune, Akatsuki Saito, Tadahiro Sasaki, Ritsuko Koketsu, Narinee Srimark, Juthamas Phadungsombat, Masaru Yokoyama, Osamu Kotani, Hironori Sato, Atsushi Yamanaka, Saori Haga, Toru Okamoto, Takeshi Kurosu, Emi E Nakayama, Tatsuo Shioda
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 1, p e0011885 (2024)
Dengue is a mosquito-borne disease that has spread to over 100 countries. Its symptoms vary from the relatively mild acute febrile illness called dengue fever to the much more severe dengue shock syndrome. Dengue is caused by dengue virus (DENV), whi
Externí odkaz:
https://doaj.org/article/41fb754db4244c05a9a5a5e6dfd43ecb
Publikováno v:
Viruses, Vol 15, Iss 1, p 31 (2022)
Reverse transcriptase (RT) and integrase (IN) are encoded tandemly in the pol genes of retroviruses. We reported recently that HIV-1 RT and IN need to be supplied as the pol precursor intermediates, in which RT and IN are in fusion form (RTIN) to exe
Externí odkaz:
https://doaj.org/article/127c8a459d294b07b5106fe69163b0a6
Autor:
Kaori Sano, Shinji Saito, Tadaki Suzuki, Osamu Kotani, Akira Ainai, Elly van Riet, Koshiro Tabata, Kumpei Saito, Yoshimasa Takahashi, Masaru Yokoyama, Hironori Sato, Takahiro Maruno, Kaede Usami, Susumu Uchiyama, Kiyoko Ogawa-Goto, Hideki Hasegawa
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245244 (2021)
IgA antibodies, which are secreted onto the mucosal surface as secretory IgA antibodies (SIgAs), play an important role in preventing influenza virus infection. A recent study reported that anti-hemagglutinin (HA) head-targeting antibodies increase a
Externí odkaz:
https://doaj.org/article/71c6d6ec89a6457aaa7f19cfaf47906a
Autor:
Mai Izumida, Osamu Kotani, Hideki Hayashi, Chris Smith, Tsutomu Fukuda, Koushirou Suga, Masatomo Iwao, Fumito Ishibashi, Hironori Sato, Yoshinao Kubo
Publikováno v:
Viruses, Vol 14, Iss 4, p 816 (2022)
Lamellarin α 20-sulfate is a cell-impenetrable marine alkaloid that can suppress infection that is mediated by the envelope glycoprotein of human immunodeficiency virus type 1. We explored the antiviral action and mechanisms of this alkaloid against
Externí odkaz:
https://doaj.org/article/6ca6edef37b7450e8dbc2bc0a5a15488
Autor:
Osamu Kotani, Yasushi Suzuki, Shinji Saito, Akira Ainai, Akira Ueno, Takuya Hemmi, Kaori Sano, Koshiro Tabata, Masaru Yokoyama, Tadaki Suzuki, Hideki Hasegawa, Hironori Sato
Publikováno v:
Viruses, Vol 13, Iss 9, p 1733 (2021)
The stalk domain of influenza virus envelope glycoprotein hemagglutinin (HA) constitutes the axis connecting the head and transmembrane domains, and plays pivotal roles in conformational rearrangements of HA for virus infection. Here we characterized
Externí odkaz:
https://doaj.org/article/be8f6463c0c645ff88efe235c222eb6c
Autor:
Naoya Doi, Masaru Yokoyama, Takaaki Koma, Osamu Kotani, Hironori Sato, Akio Adachi, Masako Nomaguchi
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
HIV-1 Env protein functions in the entry process and is the target of neutralizing antibodies. Its intrinsically high mutation rate is certainly one of driving forces for persistence/survival in hosts. For optimal replication in various environments,
Externí odkaz:
https://doaj.org/article/581718e28d494d2db72d1e7bec162e87
Autor:
Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato, Hirokazu Tamamura
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 208 (2021)
The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral RNA and is highly conserved among many strains of the virus. It forms a conical structure by assembling oligomers of capsid (CA) proteins. CA dysfunction is expe
Externí odkaz:
https://doaj.org/article/ad98c30fb1f14fafb0fb4db8256601af
Autor:
Osamu Kotani, Asif Naeem, Tadaki Suzuki, Naoko Iwata-Yoshikawa, Yuko Sato, Noriko Nakajima, Takushi Hosomi, Hiroyuki Tsukagoshi, Kunihisa Kozawa, Hideki Hasegawa, Fumihiro Taguchi, Hiroyuki Shimizu, Noriyo Nagata
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148184 (2016)
Saffold virus (SAFV), a picornavirus, is occasionally detected in children with acute flaccid paralysis, meningitis, and cerebellitis; however, the neuropathogenicity of SAFV remains undetermined.The virulence of two clinical isolates of SAFV type 3
Externí odkaz:
https://doaj.org/article/ecd1ab332a434c9d8c8e4036babab158
Autor:
Chikako Kataoka, Tadaki Suzuki, Osamu Kotani, Naoko Iwata-Yoshikawa, Noriyo Nagata, Yasushi Ami, Takaji Wakita, Yorihiro Nishimura, Hiroyuki Shimizu
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005033 (2015)
Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease, occasionally causes severe neurological symptoms. We identified P-selectin glycoprotein ligand-1 (PSGL-1) as an EV71 receptor and found that an amino acid residue 145 in
Externí odkaz:
https://doaj.org/article/6f75096e42ef452a8afdbfdfb318adc9