Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Osamu Kikuchi"'
Autor:
Yosuke Mitani, Shinya Ohashi, Osamu Kikuchi, Yukie Nakai, Tomomi Ida, Ayaka Mizumoto, Yoshihiro Yamamoto, Tomoki Saito, Shigeki Kataoka, Junichi Matsubara, Atsushi Yamada, Masashi Kanai, Shigemi Matsumoto, Hiroaki Sakai, Kiyotsugu Yoshikawa, Eijiro Nakamura, Manabu Muto
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Clinical cancer genome sequencing detects oncogenic variants that are potential targets for cancer treatment, but it also detects variants of unknown significance. These variants may interact with each other to influence tumor pathophysiolog
Externí odkaz:
https://doaj.org/article/a5a28560b24a488aa789094fa8f44f21
Autor:
Tianxia Li, Osamu Kikuchi, Jin Zhou, Yichen Wang, Babita Pokharel, Klavdija Bastl, Prafulla Gokhale, Aine Knott, Yanxi Zhang, John G. Doench, Zandra V. Ho, Daniel V.T. Catenacci, Adam J. Bass
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Gastroesophageal adenocarcinomas (GEAs) harbor recurrent amplification of KRAS, leading to marked overexpression of WT KRAS protein. We previously demonstrated that SHP2 phosphatase, which acts to promote KRAS and downstream MAPK pathway activation,
Externí odkaz:
https://doaj.org/article/4e331ae8a1294fbe92f680cc6ff5b939
Autor:
Min Zhao, Katsuhide Okunishi, Yun Bu, Osamu Kikuchi, Hao Wang, Tadahiro Kitamura, Tetsuro Izumi
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Activin receptor-like kinase 7 (ALK7) is a type I receptor in the TGF-β superfamily preferentially expressed in adipose tissue and associated with lipid metabolism. Inactivation of ALK7 signaling in mice results in increased lipolysis and resistance
Externí odkaz:
https://doaj.org/article/80cd115b81b84e39bd02a3ff294c2061
Autor:
Takashi Kijima, Hiroshi Nakagawa, Masataka Shimonosono, Prasanna M. Chandramouleeswaran, Takeo Hara, Varun Sahu, Yuta Kasagi, Osamu Kikuchi, Koji Tanaka, Veronique Giroux, Amanda B. Muir, Kelly A. Whelan, Shinya Ohashi, Seiji Naganuma, Andres J. Klein-Szanto, Yoshiaki Shinden, Ken Sasaki, Itaru Omoto, Yoshiaki Kita, Manabu Muto, Adam J. Bass, J. Alan Diehl, Gregory G. Ginsberg, Yuichiro Doki, Masaki Mori, Yasuto Uchikado, Takaaki Arigami, Narayan G. Avadhani, Devraj Basu, Anil K. Rustgi, Shoji Natsugoe
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thr
Externí odkaz:
https://doaj.org/article/7488edc6ab024bcda04958703e1f2938
Autor:
Norikiyo Honzawa, Kei Fujimoto, Masaki Kobayashi, Daisuke Kohno, Osamu Kikuchi, Hiromi Yokota-Hashimoto, Eri Wada, Yuichi Ikeuchi, Yoko Tabei, Gerald W. Dorn, Kazunori Utsunomiya, Rimei Nishimura, Tadahiro Kitamura
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 4003 (2022)
The pathophysiology of type 2 diabetes involves insulin and glucagon. Protein kinase C (Pkc)-δ, a serine–threonine kinase, is ubiquitously expressed and involved in regulating cell death and proliferation. However, the role of Pkcδ in regulating
Externí odkaz:
https://doaj.org/article/12bc0503cad04889806588fa598bb2f5
Autor:
Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, Keisuke Yaku, Ayumu Inutsuka, Hiromi Yokota-Hashimoto, Osamu Kikuchi, Takayoshi Suga, Masaki Kobayashi, Akihiro Yamanaka, Akihiro Harada, Takashi Nakagawa, Tatsushi Onaka, Tadahiro Kitamura
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
SIRT1 is a NAD+-dependent deacetylase whose functions have been linked to organismal longevity, aging and metabolism. Here, Matsui and colleagues show that neuronal SIRT1 can affect nutrient-related dietary choice in mice, and this effect is mediated
Externí odkaz:
https://doaj.org/article/0e6908642176438fbd24e41a6c8e07f1
Publikováno v:
iScience, Vol 23, Iss 1, Pp - (2020)
Summary: Pancreatic endocrine cell development into differentiated α- and β-cells is highly regulated and involves multiple transcription factors. However, the mechanisms behind the determination of α- and β-cell masses remains unclear. We previo
Externí odkaz:
https://doaj.org/article/51fc8fca1db546d4a69ccb17ff7fb711
Autor:
Shinya Ohashi, Osamu Kikuchi, Mihoko Tsurumaki, Yukie Nakai, Hiroi Kasai, Takahiro Horimatsu, Shin'ichi Miyamoto, Akira Shimizu, Tsutomu Chiba, Manabu Muto
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103126 (2014)
Photodynamic therapy (PDT) kills cancer cells via a photochemical reaction mediated by an oncotropic photosensitizer. Herein, we performed an experimental preclinical study to validate the anti-tumour effect of talaporfin sodium-mediated PDT (t-PDT)
Externí odkaz:
https://doaj.org/article/c3cb8617c2904b1a94e13f8281c8783e
A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting.
Autor:
Mas Rizky A A Syamsunarno, Tatsuya Iso, Hirofumi Hanaoka, Aiko Yamaguchi, Masaru Obokata, Norimichi Koitabashi, Kosaku Goto, Takako Hishiki, Yoshiko Nagahata, Hiroki Matsui, Motoaki Sano, Masaki Kobayashi, Osamu Kikuchi, Tsutomu Sasaki, Kazuhisa Maeda, Masami Murakami, Tadahiro Kitamura, Makoto Suematsu, Yoshito Tsushima, Keigo Endo, Gökhan S Hotamisligil, Masahiko Kurabayashi
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79386 (2013)
During prolonged fasting, fatty acid (FA) released from adipose tissue is a major energy source for peripheral tissues, including the heart, skeletal muscle and liver. We recently showed that FA binding protein 4 (FABP4) and FABP5, which are abundant
Externí odkaz:
https://doaj.org/article/313b799d588245c7b0fbc00ae4d2a41b
Autor:
Yukari Ido-Kitamura, Tsutomu Sasaki, Masaki Kobayashi, Hye-Jin Kim, Yong-Soo Lee, Osamu Kikuchi, Hiromi Yokota-Hashimoto, Katsumi Iizuka, Domenico Accili, Tadahiro Kitamura
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47231 (2012)
In liver, glucose utilization and lipid synthesis are inextricably intertwined. When glucose availability exceeds its utilization, lipogenesis increases, leading to increased intrahepatic lipid content and lipoprotein secretion. Although the fate of
Externí odkaz:
https://doaj.org/article/e6af08486ff941eabc7f045643470d28