Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Osamu KIKUCHI"'
Autor:
Osamu Kikuchi, Yuichi Ikeuchi, Masaki Kobayashi, Yoko Tabei, Hiromi Yokota‐Hashimoto, Tadahiro Kitamura
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 9, Pp 1177-1190 (2024)
Abstract Aims/Introduction Imeglimin is a recently approved oral antidiabetic agent that improves insulin resistance, and promotes insulin secretion from pancreatic β‐cells. Here, we investigated the effects of imeglimin on glucagon secretion from
Externí odkaz:
https://doaj.org/article/b421d60f1b0b47b1858c0736d304e692
Autor:
Kohei Kometani, Takaaki Yorimitsu, Norihide Jo, Erina Yamaguchi, Osamu Kikuchi, Masaru Fukahori, Takeshi Sawada, Yoshitaka Tsujimoto, Ayana Sunami, Mengqian Li, Takeshi Ito, Yann Pretemer, Yuxian Gao, Yu Hidaka, Masaki Yamamoto, Natsuko Kaku, Yu Nakagama, Yasutoshi Kido, Alba Grifoni, Alessandro Sette, Miki Nagao, Satoshi Morita, Takako E. Nakajima, Manabu Muto, Yoko Hamazaki
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Age-associated differences in the effect of repetitive vaccination, particularly on memory T-cell and B-cell responses, remain unclear. While older adults (aged ≥65 years) exhibited enhanced IgG responses following COVID-19 mRNA booster vaccination
Externí odkaz:
https://doaj.org/article/55cbf79532624fedb38c0d467fdae2ae
Autor:
Yosuke Mitani, Shinya Ohashi, Osamu Kikuchi, Yukie Nakai, Tomomi Ida, Ayaka Mizumoto, Yoshihiro Yamamoto, Tomoki Saito, Shigeki Kataoka, Junichi Matsubara, Atsushi Yamada, Masashi Kanai, Shigemi Matsumoto, Hiroaki Sakai, Kiyotsugu Yoshikawa, Eijiro Nakamura, Manabu Muto
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Clinical cancer genome sequencing detects oncogenic variants that are potential targets for cancer treatment, but it also detects variants of unknown significance. These variants may interact with each other to influence tumor pathophysiolog
Externí odkaz:
https://doaj.org/article/a5a28560b24a488aa789094fa8f44f21
Autor:
Tianxia Li, Osamu Kikuchi, Jin Zhou, Yichen Wang, Babita Pokharel, Klavdija Bastl, Prafulla Gokhale, Aine Knott, Yanxi Zhang, John G. Doench, Zandra V. Ho, Daniel V.T. Catenacci, Adam J. Bass
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Gastroesophageal adenocarcinomas (GEAs) harbor recurrent amplification of KRAS, leading to marked overexpression of WT KRAS protein. We previously demonstrated that SHP2 phosphatase, which acts to promote KRAS and downstream MAPK pathway activation,
Externí odkaz:
https://doaj.org/article/4e331ae8a1294fbe92f680cc6ff5b939
Autor:
Min Zhao, Katsuhide Okunishi, Yun Bu, Osamu Kikuchi, Hao Wang, Tadahiro Kitamura, Tetsuro Izumi
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Activin receptor-like kinase 7 (ALK7) is a type I receptor in the TGF-β superfamily preferentially expressed in adipose tissue and associated with lipid metabolism. Inactivation of ALK7 signaling in mice results in increased lipolysis and resistance
Externí odkaz:
https://doaj.org/article/80cd115b81b84e39bd02a3ff294c2061
Autor:
Takashi Kijima, Hiroshi Nakagawa, Masataka Shimonosono, Prasanna M. Chandramouleeswaran, Takeo Hara, Varun Sahu, Yuta Kasagi, Osamu Kikuchi, Koji Tanaka, Veronique Giroux, Amanda B. Muir, Kelly A. Whelan, Shinya Ohashi, Seiji Naganuma, Andres J. Klein-Szanto, Yoshiaki Shinden, Ken Sasaki, Itaru Omoto, Yoshiaki Kita, Manabu Muto, Adam J. Bass, J. Alan Diehl, Gregory G. Ginsberg, Yuichiro Doki, Masaki Mori, Yasuto Uchikado, Takaaki Arigami, Narayan G. Avadhani, Devraj Basu, Anil K. Rustgi, Shoji Natsugoe
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thr
Externí odkaz:
https://doaj.org/article/7488edc6ab024bcda04958703e1f2938
Publikováno v:
iScience, Vol 23, Iss 1, Pp - (2020)
Summary: Pancreatic endocrine cell development into differentiated α- and β-cells is highly regulated and involves multiple transcription factors. However, the mechanisms behind the determination of α- and β-cell masses remains unclear. We previo
Externí odkaz:
https://doaj.org/article/51fc8fca1db546d4a69ccb17ff7fb711
Autor:
Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, Keisuke Yaku, Ayumu Inutsuka, Hiromi Yokota-Hashimoto, Osamu Kikuchi, Takayoshi Suga, Masaki Kobayashi, Akihiro Yamanaka, Akihiro Harada, Takashi Nakagawa, Tatsushi Onaka, Tadahiro Kitamura
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
SIRT1 is a NAD+-dependent deacetylase whose functions have been linked to organismal longevity, aging and metabolism. Here, Matsui and colleagues show that neuronal SIRT1 can affect nutrient-related dietary choice in mice, and this effect is mediated
Externí odkaz:
https://doaj.org/article/0e6908642176438fbd24e41a6c8e07f1
Autor:
Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Junichi Matsubara, Atsushi Yamada, Shin’ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Hiroshi Seno, Manabu Muto
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-13 (2017)
Abstract Background Epidermal growth factor receptor (EGFR) plays a pivotal role in the pathophysiology of esophageal squamous cell carcinoma (ESCC). However, the clinical effects of EGFR inhibitors on ESCC are controversial. This study sought to ide
Externí odkaz:
https://doaj.org/article/f2da9f00339e4006a6773cac75a451f6
Autor:
Shinya Ohashi, Osamu Kikuchi, Mihoko Tsurumaki, Yukie Nakai, Hiroi Kasai, Takahiro Horimatsu, Shin'ichi Miyamoto, Akira Shimizu, Tsutomu Chiba, Manabu Muto
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103126 (2014)
Photodynamic therapy (PDT) kills cancer cells via a photochemical reaction mediated by an oncotropic photosensitizer. Herein, we performed an experimental preclinical study to validate the anti-tumour effect of talaporfin sodium-mediated PDT (t-PDT)
Externí odkaz:
https://doaj.org/article/c3cb8617c2904b1a94e13f8281c8783e