Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Osamu Hiramatsu"'
Autor:
Yasuo Ogasawara, Osamu Hiramatsu, Toyotaka Yada, Masahito Kajiya, Fumihiko Kajiya, Yousuke Inai
Publikováno v:
Medical & Biological Engineering & Computing. 46:411-419
The phase opposition of velocity waveforms between coronary arteries (predominantly diastolic) and veins (systolic) is the most prominent characteristic of coronary hemodynamics. This unique arterial and venous flow patterns indicate the importance o
Autor:
Hidezo Mori, Yoshitaka Morita, Yasuo Ogasawara, Yoshiro Shinozaki, Hiroaki Shimokawa, Toyotaka Yada, Yoshisuke Haruna, Masami Goto, Naoki Kashihara, Fumihiko Kajiya, Osamu Hiramatsu
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 291:H1138-H1146
We have recently demonstrated that endogenous H2O2 plays an important role in coronary autoregulation in vivo. However, the role of H2O2 during coronary ischemia-reperfusion (I/R) injury remains to be examined. In this study, we examined whether endo
Autor:
Seiichi Mochizuki, Osamu Hiramatsu, Fumihiko Kajiya, Yoko Chiba, Yasuo Ogasawara, Eiji Toyota, Hiroyuki Tachibana, Hiroshi Nakamoto
Publikováno v:
Heart and Vessels. 20:175-178
Nipradilol (NP: 3,4-dihydro-8-[2-hydroxy-3-isopropylamino]propoxy-3-nitroxy-2H-1-benzopyran) shows not only beta-adrenoreceptor-blocking effects but also nitroglycerin-like vasodilatory action. We aimed to directly measure NP-derived nitric oxide (NO
Autor:
Fumihiko Kajiya, Osamu Hiramatsu, Shinji Yamamori, Hiroyuki Tachibana, Eiji Toyota, Yasuo Ogasawara, William M. Chilian
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 288:H1598-H1603
The subendocardium is the most vulnerable area of the left ventricle to the effects of hypoperfusion and ischemia. Despite this well-acknowledged observation, the mechanisms underlying this susceptibility are not elucidated, although numerous explana
Autor:
Masahito Kajiya, Yasuo Ogasawara, Satoshi Mohri, Osamu Hiramatsu, Toyotaka Yada, Takahiko Kiyooka, Juichiro Shimizu, Eiji Toyota, Fumihiko Kajiaya
Publikováno v:
Journal of Mechanics in Medicine and Biology. :1-9
The recently proposed Physiome is considered as a powerful successor to the Genome. The definition of Physiome is the quantitative description of the physiological dynamics or functions of the intact organism. The physiome includes integration of kno
Autor:
Takahiko Kiyooka, Fumihiko Kajiya, Hiroyuki Tachibana, Fumiyuki Shigeto, Hiroshi Nakamoto, Taro Morimoto, Tohru Ohe, Masahito Kajiya, Yuki Morizane, Osamu Hiramatsu, Yasuo Ogasawara, Juichiro Shimizu, Satoshi Mohri, Toyotaka Yada
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 288:H1437-H1443
Using high-resolution intravital charge-coupled device video microscopy, we visualized the epicardial capillary network of the beating canine heart in vivo to elucidate its functional role under control conditions, during reactive hyperemia (RH), and
Autor:
Masami Goto, Takahiko Kiyooka, Fumiyuki Shigeto, Hidezo Mori, Yoshiro Shinozaki, Tatsuya Kajita, Osamu Hiramatsu, Toyotaka Yada, Fumihiko Kajiya, Seitaro Ohkuma, Hiroaki Shimokawa, Etsuro Tanaka, Masashi Katsura, Yasuo Ogasawara
Publikováno v:
Journal of the American College of Cardiology. 45:599-607
ObjectivesWe examined whether hydroxyfasudil, a specific Rho-kinase inhibitor, exerts cardioprotective effect on coronary ischemia/reperfusion (I/R) injury and, if so, whether nitric oxide (NO) is involved.BackgroundRecent studies have demonstrated t
Autor:
Tatsuya Kajita, Eiji Toyota, Yasuo Ogasawara, Fumiyuki Shigeto, Masami Goto, Toyotaka Yada, Seiichi Mochizuki, Osamu Hiramatsu, Hiroshi Nakamoto, Pieter Sipkema, Fumihiko Kajiya
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 288:H553-H558
Exogenous nitric oxide (NO) suppresses endothelium-derived NO production. We were interested in determining whether this is also the case in flow-induced endothelium-derived NO production. If so, then is the mechanism because of intracellular depleti
Autor:
Hiroto Matsuda, Toyotaka Yada, Hiroshi Nakamoto, Eiji Toyota, Fumihiko Kajiya, Osamu Hiramatsu, Koki Arakawa, Koichi Hayashi, Hiromichi Suzuki, Hiroyuki Tachibana, Masami Goto, Yasuo Ogasawara
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H1785-H1792
Time-sequential responses to endothelium-dependent and -independent vasodilators and angiotensin-converting enzyme (ACE) inhibitors were studied in the subendocardial arterioles (Endo) of canine renovascular hypertension (HT) compared with subepicard
Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release
Autor:
Seiichi Mochizuki, Tatsuya Kajita, Osamu Hiramatsu, Fumihiko Kajiya, Fumiyuki Shigeto, Hans Vink, Jos A. E. Spaan
Publikováno v:
American journal of physiology. Heart and circulatory physiology, 285(2), H722-H726. American Physiological Society
Endothelium-derived nitric oxide (NO) is synthesized in response to chemical and physical stimuli. Here, we investigated a possible role of the endothelial cell glycocalyx as a biomechanical sensor that triggers endothelial NO production by transmitt