Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Osamu Hashizume"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Adenomatous polyposis coli (APC) is a tumor-suppressing protein whose inactivation triggers the formation of colorectal polyps. Numerous studies using cell lines or genetically engineered mice have revealed its role in suppressing Wnt/β-cat
Externí odkaz:
https://doaj.org/article/2b1a581672fc4c0aa6e1d5883a21459d
Autor:
Tasuku Ishii, Yosuke Funato, Osamu Hashizume, Daisuke Yamazaki, Yusuke Hirata, Kiyoji Nishiwaki, Nozomu Kono, Hiroyuki Arai, Hiroaki Miki
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006276 (2016)
Mg2+ serves as an essential cofactor for numerous enzymes and its levels are tightly regulated by various Mg2+ transporters. Here, we analyzed Caenorhabditis elegans strains carrying mutations in genes encoding cyclin M (CNNM) Mg2+ transporters. We i
Externí odkaz:
https://doaj.org/article/a4d01a31372645a58a287853c1a6f2b7
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118561 (2015)
We previously found that mouse mitochondrial DNA (mtDNA) with a G13997A mutation (G13997A mtDNA) controls not only the transformation of cultured lung carcinoma cells from poorly metastatic into highly metastatic cells, but also the transformation of
Externí odkaz:
https://doaj.org/article/ff74b90840824286a8f5a3048cfd5450
Autor:
Takayuki Mito, Yoshiaki Kikkawa, Akinori Shimizu, Osamu Hashizume, Shun Katada, Hirotake Imanishi, Azusa Ota, Yukina Kato, Kazuto Nakada, Jun-Ichi Hayashi
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55789 (2013)
Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes accele
Externí odkaz:
https://doaj.org/article/26e751ffb9a34aad969369972af64f56
Publikováno v:
Cancer Science. 114:25-33
Phosphatase of regenerating liver (PRL) is a family of protein tyrosine phosphatases (PTPs) that are anchored to the plasma membrane by prenylation. They are frequently overexpressed in various types of malignant cancers and their roles in cancer pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff909596cba8cbd0cdb0db9d55014ce
https://doi.org/10.1111/cas.15625
https://doi.org/10.1111/cas.15625
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Adenomatous polyposis coli (APC) is a tumor-suppressing protein whose inactivation triggers the formation of colorectal polyps. Numerous studies using cell lines or genetically engineered mice have revealed its role in suppressing Wnt/β-catenin sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b5d3cb602f45a6417cc732b5646229
https://doaj.org/article/2b1a581672fc4c0aa6e1d5883a21459d
https://doaj.org/article/2b1a581672fc4c0aa6e1d5883a21459d
Publikováno v:
Antioxidants & Redox Signaling. 33:20-34
Aims: Mg2+ is fundamental for life, and its shortage severely impairs vital functions. However, whether excessive Mg2+ has beneficial or adverse effects has remained unknown. To clarify this issue,...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efa5c8026f03e2d8392845927ce5a709
https://doi.org/10.1089/ars.2019.7951
https://doi.org/10.1089/ars.2019.7951
Autor:
Atsushi Yoshida, Yosuke Funato, Daisuke Yamazaki, Hiroaki Miki, Osamu Hashizume, Yusuke Hirata
Publikováno v:
Developmental cell. 55(4)
Extracellular pH is usually maintained around 7.4 in multicellular organisms, and cells are optimized to proliferate under this condition. Here, we find cells can adapt to a more acidic pH of 6.5 and become addicted to this acidic microenvironment by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889cd8bf8260e9d8c9aeab161823f405
https://pubmed.ncbi.nlm.nih.gov/33232671
https://pubmed.ncbi.nlm.nih.gov/33232671
Publikováno v:
Antioxidantsredox signaling. 33(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d7452026d19e84951a44aec66a5b011
https://pubmed.ncbi.nlm.nih.gov/32148064
https://pubmed.ncbi.nlm.nih.gov/32148064
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 95:3-S41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75587c38fcf10c3e55c39e42cd2684f8
https://doi.org/10.1254/jpssuppl.95.0_3-s41-1
https://doi.org/10.1254/jpssuppl.95.0_3-s41-1