Výsledky vyhledávání - "Osama El-Assal"

2619. Clinical Characteristics and Etiology of Community-Acquired Pneumonia in Children: A Contemporary, Prospective, Multicenter Study in Ohio, 2015–2018

Autor: Ki Wook Yun, Rebecca Wallihan, Ankita P Desai, Sherman J Alter, Lilliam Ambroggio, Daniel M Cohen, Osama El-Assal, Sarah Marzec, Todd A Florin, Meghan Keaton, Samir S Shah, Asuncion Mejias, Octavio Ramilo

Publikováno v: Open Forum Infectious Diseases

Background Worldwide, pneumonia is the leading cause of death in children Methods We conducted a prospective, multicenter, observational study of CAP among previously healthy children aged 2 months through 18 years in six children’s hospitals in Oh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a12f4822807931505a06b0cda857c4e
https://doi.org/10.1093/ofid/ofz360.2297

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Innate Immune Function Predicts the Development of Nosocomial Infection in Critically Injured Children

Autor: Jennifer A. Muszynski, Gail E. Besner, Lisa Steele, Mark W. Hall, Lisa Hanson-Huber, Kathleen Nicol, Osama El-Assal, Corey Raffel, Susan Geyer, Ryan Nofziger, Jyotsna Nateri, Kristin Greathouse, Jonathan I. Groner

Publikováno v: Shock (Augusta, Ga.), vol 42, iss 4

BACKGROUND Critical injury has been associated with reduction in innate immune function in adults, with infection risk being related to degree of immune suppression. This relationship has not been reported in critically injured children. HYPOTHESIS I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2c14e0416d2a9f577af5e18f6cc355
https://doi.org/10.1097/shk.0000000000000217

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261. Alternative Antibiotic Prescribing for Community Acquired Pneumonia (CAP) in Pediatric Patients in Relation to Allergy Status

Autor: Asuncion Mejias, Bhavana Gorti, Richard M. Ruddy, Osama El-Assal, Sherman J. Alter, Meghan Keaton, Octavio Ramilo, Todd A. Florin, Daniel Cohen, Lilliam Ambroggio, Rebecca Wallihan, Ankita Desai, Samir S. Shah

Publikováno v: Open Forum Infectious Diseases

Background While 10% of the population may report a penicillin (PCN) allergy, it has been shown that 90% of these patients are not allergic and may still be able to take PCN safely. Inaccurate reporting of a PCN allergy may lead to prescription of ot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869170560e29388ac0b5e5e23e910f40
http://europepmc.org/articles/PMC6255626

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Heparin-binding epidermal growth factor–like growth factor gene disruption is associated with delayed intestinal restitution, impaired angiogenesis, and poor survival after intestinal ischemia in mice

Autor: Alejandro Marquez, Heather N. Paddock, Osama El-Assal, Gail E. Besner

Publikováno v: Journal of Pediatric Surgery. 43:1182-1190

Purpose We have demonstrated that administration of heparin-binding epidermal growth factor–like growth factor (HB-EGF) protects the intestines from injury. The aim of the current study was to evaluate the effect of HB-EGF gene disruption on intest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2c267e0e1a51008464fdd17ef8c52db
https://doi.org/10.1016/j.jpedsurg.2008.02.053

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IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver

Autor: Osama, El-Assal, Feng, Hong, Won-Ho, Kim, Svetlana, Radaeva, Bin, Gao

Publikováno v: Cellularmolecular immunology. 1(3)

Interleukin-6 (IL-6)-deficient mice are prone to ethanol-induced apoptosis and steatosis in the liver; however, the underlying mechanism is not fully understood. Mitochondrial dysfunction caused by oxidative stress is an early event that plays an imp

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https://pubmed.ncbi.nlm.nih.gov/16219169

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In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats

Autor: Zhaoli, Sun, Andrew S, Klein, Svetlana, Radaeva, Feng, Hong, Osama, El-Assal, Hong-Na, Pan, Barbara, Jaruga, Sandor, Batkai, Sumito, Hoshino, Zhigang, Tian, George, Kunos, Anna Mae, Diehl, Bin, Gao

Publikováno v: Gastroenterology. 125(1)

Orthotopic liver transplantation is currently the only curative therapy for chronic end-stage liver disease and acute liver failure. However, a scarcity of cadaveric donors has led to a critical shortage of organs available for transplant. This is fu

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https://pubmed.ncbi.nlm.nih.gov/12851891

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Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes

Autor: Svetlana Radaeva, Youhua Liu, Bin Gao, Hongbo Cai, Saijun Fan, Feng Hong, Won Ho Kim, Osama El–Assal, Barbara Jaruga, Stephen C. Strom

Publikováno v: Gastroenterology. 122(4)

Background & Aims: Interferon (IFN)-α therapy is currently the primary choice for viral hepatitis and a promising treatment for hepatocellular carcinoma (HCC). Primary mouse and rat hepatocytes respond poorly to IFN-α stimulation. Thus, it is very

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b32e23b97c69e4c25f87c0a422698f8
https://pubmed.ncbi.nlm.nih.gov/11910354

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