Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Osama E. Demerdash"'
Autor:
Tim DD Somerville, Giulia Biffi, Juliane Daßler-Plenker, Stella K Hur, Xue-Yan He, Krysten E Vance, Koji Miyabayashi, Yali Xu, Diogo Maia-Silva, Olaf Klingbeil, Osama E Demerdash, Jonathan B Preall, Michael A Hollingsworth, Mikala Egeblad, David A Tuveson, Christopher R Vakoc
Publikováno v:
eLife, Vol 9 (2020)
A highly aggressive subset of pancreatic ductal adenocarcinomas undergo trans-differentiation into the squamous lineage during disease progression. Here, we investigated whether squamous trans-differentiation of human and mouse pancreatic cancer cell
Externí odkaz:
https://doaj.org/article/4fcfc6a231cd4f61864e83587e8f8c51
Autor:
Stella K. Hur, Tim D.D. Somerville, Xiaoli S. Wu, Diogo Maia-Silva, Osama E. Demerdash, David A. Tuveson, Faiyaz Notta, Christopher R. Vakoc
Publikováno v:
bioRxiv
During the progression of pancreatic ductal adenocarcinoma (PDAC), tumor cells are known to acquire transcriptional and morphological properties of the basal (also known as squamous) epithelial lineage, which leads to more aggressive disease characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f736d23bd44ca8c982ba3a3ca7ae3699
https://europepmc.org/articles/PMC10153254/
https://europepmc.org/articles/PMC10153254/
Autor:
Christopher R. Vakoc, Maria E. Figueroa, W. Richard McCombie, Emily Hodges, Sara Goodwin, Kenneth Chang, Sofya A. Polyanskaya, Osama E. Demerdash, Olaf Klingbeil, Emmalee R. Adelman, Melissa Kramer, Zhaolin Yang, Ana S.H. Costa, Shruti V. Iyer, Damianos S. Skopelitis, Yu-Han Huang, Yiliang Wei
Supplementary Table 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cf70d903de0c807ee13b3006ac8c34
https://doi.org/10.1158/2159-8290.22540466
https://doi.org/10.1158/2159-8290.22540466
Supplementary Figures S1-S17 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia
Autor:
Christopher R. Vakoc, Maria E. Figueroa, W. Richard McCombie, Emily Hodges, Sara Goodwin, Kenneth Chang, Sofya A. Polyanskaya, Osama E. Demerdash, Olaf Klingbeil, Emmalee R. Adelman, Melissa Kramer, Zhaolin Yang, Ana S.H. Costa, Shruti V. Iyer, Damianos S. Skopelitis, Yu-Han Huang, Yiliang Wei
Figures S1 to S17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e662c53944ae25bb50182b91581bd81c
https://doi.org/10.1158/2159-8290.22540472
https://doi.org/10.1158/2159-8290.22540472
Autor:
Christopher R. Vakoc, Agata Smogorzewska, Maria E. Figueroa, W. Richard McCombie, Emily Hodges, Sara Goodwin, Kenneth Chang, Osama E. Demerdash, Melissa Kramer, Joseph P. Milazzo, Olaf Klingbeil, Emmalee R. Adelman, Francis P. Lach, Moonjung Jung, Shruti V. Iyer, Sofya A. Polyanskaya, Yiliang Wei, Xiaoli S. Wu, Zhaolin Yang
Hundreds of genes become aberrantly silenced in acute myeloid leukemia (AML), with most of these epigenetic changes being of unknown functional consequence. Here, we demonstrate how gene silencing can lead to an acquired dependency on the DNA repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af2b7c42f06fde3a5b35a86833cbf58
https://doi.org/10.1158/2159-8290.c.6549278.v1
https://doi.org/10.1158/2159-8290.c.6549278.v1
Autor:
Christopher R. Vakoc, Maria E. Figueroa, W. Richard McCombie, Emily Hodges, Sara Goodwin, Kenneth Chang, Sofya A. Polyanskaya, Osama E. Demerdash, Olaf Klingbeil, Emmalee R. Adelman, Melissa Kramer, Zhaolin Yang, Ana S.H. Costa, Shruti V. Iyer, Damianos S. Skopelitis, Yu-Han Huang, Yiliang Wei
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c16067cf54850ca35e975820451a4f
https://doi.org/10.1158/2159-8290.22540469
https://doi.org/10.1158/2159-8290.22540469
Autor:
Christopher R. Vakoc, Agata Smogorzewska, Maria E. Figueroa, W. Richard McCombie, Emily Hodges, Sara Goodwin, Kenneth Chang, Osama E. Demerdash, Melissa Kramer, Joseph P. Milazzo, Olaf Klingbeil, Emmalee R. Adelman, Francis P. Lach, Moonjung Jung, Shruti V. Iyer, Sofya A. Polyanskaya, Yiliang Wei, Xiaoli S. Wu, Zhaolin Yang
The E2/E3 sgRNA guide sequences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e531a1a5aa2df3cb808f2992ff63ff
https://doi.org/10.1158/2159-8290.22540091.v1
https://doi.org/10.1158/2159-8290.22540091.v1
Autor:
Christopher R. Vakoc, Maria E. Figueroa, W. Richard McCombie, Emily Hodges, Sara Goodwin, Kenneth Chang, Sofya A. Polyanskaya, Osama E. Demerdash, Olaf Klingbeil, Emmalee R. Adelman, Melissa Kramer, Zhaolin Yang, Ana S.H. Costa, Shruti V. Iyer, Damianos S. Skopelitis, Yu-Han Huang, Yiliang Wei
An enhanced requirement for nutrients is a hallmark property of cancer cells. Here, we optimized an in vivo genetic screening strategy in acute myeloid leukemia (AML), which led to the identification of the myo-inositol transporter SLC5A3 as a depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c303aa3d7206f473a52cac69e4886b59
https://doi.org/10.1158/2159-8290.c.6549386.v1
https://doi.org/10.1158/2159-8290.c.6549386.v1
SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Autor:
Sofya A. Polyanskaya, Rosamaria Y. Moreno, Bin Lu, Ruopeng Feng, Yu Yao, Seema Irani, Olaf Klingbeil, Zhaolin Yang, Yiliang Wei, Osama E. Demerdash, Lukas A. Benjamin, Mitchell J. Weiss, Yan Jessie Zhang, Christopher R. Vakoc
Publikováno v:
Cell reports
SUMMARY Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we use domain-focused CRISPR screening and identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c91745687cd5858c5579fe8e011b536
https://doi.org/10.1016/j.celrep.2021.110233
https://doi.org/10.1016/j.celrep.2021.110233
Publikováno v:
Clinical Oncology Week; 8/12/2024, p1029-1029, 1p