Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Osama A. Dalahmah"'
Autor:
Hairong Wang, Michael G. Argenziano, Hyunsoo Yoon, Deborah Boyett, Akshay Save, Petros Petridis, William Savage, Pamela Jackson, Andrea Hawkins-Daarud, Nhan Tran, Leland Hu, Kyle W. Singleton, Lisa Paulson, Osama Al Dalahmah, Jeffrey N. Bruce, Jack Grinband, Kristin R. Swanson, Peter Canoll, Jing Li
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Intratumoral heterogeneity poses a significant challenge to the diagnosis and treatment of recurrent glioblastoma. This study addresses the need for non-invasive approaches to map heterogeneous landscape of histopathological alterations thro
Externí odkaz:
https://doaj.org/article/d5dad2992549480bb73b3faa28c1de97
Autor:
Fahad Paryani, Ji-Sun Kwon, Christopher W. Ng, Kelly Jakubiak, Nacoya Madden, Kenneth Ofori, Alice Tang, Hong Lu, Shengnan Xia, Juncheng Li, Aayushi Mahajan, Shawn M. Davidson, Anna O. Basile, Caitlin McHugh, Jean Paul Vonsattel, Richard Hickman, Michael C. Zody, David E. Housman, James E. Goldman, Andrew S. Yoo, Vilas Menon, Osama Al-Dalahmah
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington’s disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus and bulk RNAseq, lip
Externí odkaz:
https://doaj.org/article/8951e53b83a446a78dbb4875a502960b
Autor:
Osama Al-Dalahmah, Michael G. Argenziano, Adithya Kannan, Aayushi Mahajan, Julia Furnari, Fahad Paryani, Deborah Boyett, Akshay Save, Nelson Humala, Fatima Khan, Juncheng Li, Hong Lu, Yu Sun, John F. Tuddenham, Alexander R. Goldberg, Athanassios Dovas, Matei A. Banu, Tejaswi Sudhakar, Erin Bush, Andrew B. Lassman, Guy M. McKhann, Brian J. A. Gill, Brett Youngerman, Michael B. Sisti, Jeffrey N. Bruce, Peter A. Sims, Vilas Menon, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic r
Externí odkaz:
https://doaj.org/article/84706af8be0f4cffa61c89d018e75e54
Autor:
Ryan G. Lim, Osama Al-Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Richard A. Hickman, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu Michael, Nicolette McClure, Xena E. Flowers, Jean Paul Vonsattel, Shawn Davidson, Vilas Menon, Vivek Swarup, Ernest Fraenkel, James E. Goldman, Leslie M. Thompson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Here the authors evaluate single cell gene expression from mouse and human Huntington’s disease brains, finding incomplete oligodendrocyte maturation and pathways involved. Treating mice with thiamine/biotin ameliorates molecular pathology.
Externí odkaz:
https://doaj.org/article/3ad164ee693049358f658929a36c0698
Autor:
Mathilde Pruvost, Julia Patzig, Camila Yattah, Ipek Selcen, Marylens Hernandez, Hye-Jin Park, Sarah Moyon, Shibo Liu, Malia S. Morioka, Lindsay Shopland, Osama Al-Dalahmah, Jaroslav Bendl, John F. Fullard, Panos Roussos, James Goldman, Ye He, Jeffrey L. Dupree, Patrizia Casaccia
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112848- (2023)
Summary: Oligodendrocytes are specialized cells that insulate and support axons with their myelin membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as essential for transcriptional and functional stability of myelinating
Externí odkaz:
https://doaj.org/article/3976a992f3b945e0894a415faea3fb6e
Autor:
Osama Al-Dalahmah, Alexander A. Sosunov, Yu Sun, Yang Liu, Nacoya Madden, E. Sander Connolly, Carol M. Troy, Guy M. McKhann, James E. Goldman
Publikováno v:
Cells, Vol 13, Iss 2, p 129 (2024)
In the mammalian isocortex, CD44, a cell surface receptor for extracellular matrix molecules, is present in pial-based and fibrous astrocytes of white matter but not in protoplasmic astrocytes. In the hominid isocortex, CD44+ astrocytes comprise the
Externí odkaz:
https://doaj.org/article/ca845e2049f9456694582ee77233a2d0
Autor:
Nacoya Madden, Ying Zi Jessy Mei, Kelly Jakubiak, Juncheng Li, Gunnar Hargus, James E. Goldman, Osama Al-Dalahmah
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The pathological involvement of the central nervous system in SARS-CoV2 (COVID-19) patients is established. The burden of pathology is most pronounced in the brain stem including the medulla oblongata. Hypoxic/ischemic damage is the most frequent neu
Externí odkaz:
https://doaj.org/article/059194ecb4d44417b4ffe9f363af65da
Autor:
Osama Al-Dalahmah, Kiran T. Thakur, Anna S. Nordvig, Morgan L. Prust, William Roth, Angela Lignelli, Anne-Catrin Uhlemann, Emily Happy Miller, Shajo Kunnath-Velayudhan, Armando Del Portillo, Yang Liu, Gunnar Hargus, Andrew F. Teich, Richard A. Hickman, Kurenai Tanji, James E. Goldman, Phyllis L. Faust, Peter Canoll
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-7 (2020)
Abstract We document the neuropathologic findings of a 73-year old man who died from acute cerebellar hemorrhage in the context of relatively mild SARS-CoV2 infection. The patient developed sudden onset of headache, nausea, and vomiting, immediately
Externí odkaz:
https://doaj.org/article/49cc39dc32d249feb8e72859604afdfd
Autor:
Osama Al-Dalahmah, Alexander A. Sosunov, A. Shaik, Kenneth Ofori, Yang Liu, Jean Paul Vonsattel, Istvan Adorjan, Vilas Menon, James E. Goldman
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-21 (2020)
Abstract Huntington Disease (HD) is an inherited movement disorder caused by expanded CAG repeats in the Huntingtin gene. We have used single nucleus RNASeq (snRNASeq) to uncover cellular phenotypes that change in the disease, investigating single ce
Externí odkaz:
https://doaj.org/article/f1719f17104e4f0695bed1e52350af07
Autor:
Luana C. Soares, Osama Al-Dalahmah, James Hillis, Christopher C. Young, Isaiah Asbed, Masanori Sakaguchi, Eric O’Neill, Francis G. Szele
Publikováno v:
Cells, Vol 10, Iss 11, p 3047 (2021)
Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives inflammation in disease. Gal-3’s role in the central nervous system has been less studied than in the immune system. However, recent studies show it exacerbat
Externí odkaz:
https://doaj.org/article/e15b078cf39b435ea88580a4252dd451