Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1 beta production

Autor: Sousa J, Cá B, Maceiras AR, Simões-Costa L, Fonseca KL, Fernandes AI, Ramos A, Carvalho T, Barros L, Magalhães C, Chiner-Oms Á, Machado H, Veiga MI, Singh A, Pereira R, Amorim A, Vieira J, Vieira CP, Bhatt A, Rodrigues F, Rodrigues PNS, Gagneux S, Castro AG, Guimarães JT, Bastos HN, Osório NS, Comas I, Saraiva M

Publikováno v: NATURE COMMUNICATIONS
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::388d0aed694bebe6f6e12890821d43f4
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=7383

Dispersal history of SARS-CoV-2 in Galicia, Spain.

Autor: Gallego-García P; CINBIO, Universidade de Vigo, Vigo, Spain.; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Estévez-Gómez N; CINBIO, Universidade de Vigo, Vigo, Spain.; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., De Chiara L; CINBIO, Universidade de Vigo, Vigo, Spain.; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.; Department of Biochemistry, Genetics, and Immunology, Universidade de Vigo, Vigo, Spain., Alvariño P; CINBIO, Universidade de Vigo, Vigo, Spain., Juiz-González PM; Servicio de Microbiología del Complejo Hospitalario Universitario de Ferrol, Ferrol, Spain., Torres-Beceiro I; Servicio de Microbiología del Complejo Hospitalario Universitario de Ferrol, Ferrol, Spain., Poza M; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA), University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Edificio Sur, Hospital Universitario A Coruña, As Xubias, A Coruña, Spain.; Microbiome and Health Group, Faculty of Sciences, University of A Coruña (UDC), A Coruña, Spain., Vallejo JA; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA), University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Edificio Sur, Hospital Universitario A Coruña, As Xubias, A Coruña, Spain., Rumbo-Feal S; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA), University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Edificio Sur, Hospital Universitario A Coruña, As Xubias, A Coruña, Spain., Conde-Pérez K; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA), University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Edificio Sur, Hospital Universitario A Coruña, As Xubias, A Coruña, Spain., Aja-Macaya P; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA), University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Edificio Sur, Hospital Universitario A Coruña, As Xubias, A Coruña, Spain., Ladra S; Database Laboratory, Research Center for Information and Communication Technologies (CITIC), University of A Coruña (UDC), A Coruña, Spain., Moreno-Flores A; Servicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain., Gude-González MJ; Servicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain., Coira A; Department of Microbiology, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS), Santiago de Compostela, Spain., Aguilera A; Department of Microbiology, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS), Santiago de Compostela, Spain., Costa-Alcalde JJ; Department of Microbiology, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS), Santiago de Compostela, Spain., Trastoy R; Department of Microbiology, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS), Santiago de Compostela, Spain., Barbeito-Castiñeiras G; Department of Microbiology, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS), Santiago de Compostela, Spain., García-Souto D; CiMUS, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Tubio JMC; CiMUS, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Zoology, Genetics and Physic Anthropology, Santiago de Compostela, Spain., Trigo-Daporta M; Clinical Microbiology Unit, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain., Camacho-Zamora P; Clinical Microbiology Unit, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain., Costa JG; Servicio de Microbiología, Complejo Hospitalario Universitario de Ourense, Ourense, Spain., González-Domínguez M; Servicio de Microbiología, Complejo Hospitalario Universitario de Ourense, Ourense, Spain., Canoura-Fernández L; Servicio de Microbiología, Complejo Hospitalario Universitario de Ourense, Ourense, Spain., Glez-Peña D; CINBIO, Universidade de Vigo, Vigo, Spain.; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Pérez-Castro S; Department of Microbiology, Complexo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo, Spain.; Microbiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Cabrera JJ; Department of Microbiology, Complexo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo, Spain.; Microbiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Daviña-Núñez C; Microbiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Godoy-Diz M; Department of Microbiology, Complexo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo, Spain., Treinta-Álvarez AB; Department of Microbiology, Complexo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo, Spain., Veiga MI; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Guimarães, Portugal., Sousa JC; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Guimarães, Portugal., Osório NS; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Guimarães, Portugal., Comas I; Tuberculosis Genomics Unit, BioMedicine Institute of Valencia, Spanish Research Council (CSIC), Valencia, Spain.; CIBER in Epidemiology and Public Health, Madrid, Spain.; Joint Research Unit 'Infection and Public Health', FISABIO-University of Valencia, Valencia, Spain., González-Candelas F; CIBER in Epidemiology and Public Health, Madrid, Spain.; Joint Research Unit 'Infection and Public Health', FISABIO-University of Valencia, Valencia, Spain.; Institute for Integrative Systems Biology (I2SysBio), University of Valencia-CSIC, Valencia, Spain., Hong SL; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven, University of Leuven, Leuven, Belgium., Bollen N; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven, University of Leuven, Leuven, Belgium., Dellicour S; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven, University of Leuven, Leuven, Belgium.; Spatial Epidemiology Lab, Université Libre de Bruxelles, Brussels, Belgium., Baele G; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven, University of Leuven, Leuven, Belgium., Suchard MA; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.; Department of Computational Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA., Lemey P; Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, KU Leuven, University of Leuven, Leuven, Belgium.; Global Virus Network (GVN), Baltimore, Maryland, USA., Agulla A; Servicio de Microbiología del Complejo Hospitalario Universitario de Ferrol, Ferrol, Spain., Bou G; Microbiology Research Group, Institute of Biomedical Research (INIBIC) - Interdisciplinary Center for Chemistry and Biology (CICA), University of A Coruña (UDC) - CIBER de Enfermedades Infecciosas (CIBERINFEC-ISCIII), Edificio Sur, Hospital Universitario A Coruña, As Xubias, A Coruña, Spain., Alonso-García P; Servicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain., Pérez-Del-Molino ML; Department of Microbiology, Complexo Hospitalario Universitario de Santiago de Compostela. SERGAS - Microbiology Research Group, Institute of Biomedical Research (IDIS), Santiago de Compostela, Spain., García-Campello M; Clinical Microbiology Unit, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain., Paz-Vidal I; Servicio de Microbiología, Complejo Hospitalario Universitario de Ourense, Ourense, Spain., Regueiro B; Department of Microbiology, Complexo Hospitalario Universitario de Vigo (CHUVI), SERGAS, Vigo, Spain.; Microbiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain., Posada D; CINBIO, Universidade de Vigo, Vigo, Spain.; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.; Department of Biochemistry, Genetics, and Immunology, Universidade de Vigo, Vigo, Spain.

Publikováno v: Journal of medical virology [J Med Virol] 2024 Jul; Vol. 96 (7), pp. e29773.

Demystifying dimensionality reduction techniques in the 'omics' era: A practical approach for biological science students.

Autor: Garma LD; Breast Cancer Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas - CNIO, Madrid, Spain., Osório NS; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's -PT Government Associate Laboratory, Braga, Portugal.

Publikováno v: Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology [Biochem Mol Biol Educ] 2024 Mar-Apr; Vol. 52 (2), pp. 165-178. Date of Electronic Publication: 2023 Nov 08.

Author Correction: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season.

Autor: Andrade CM; Center for Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany., Fleckenstein H; Center for Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany., Thomson-Luque R; Center for Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany., Doumbo S; Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Lima NF; Center for Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany., Anderson C; Center for Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany., Hibbert J; Center for Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany., Hopp CS; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Tran TM; Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN, USA., Li S; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Niangaly M; Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Cisse H; Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Doumtabe D; Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Skinner J; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Sturdevant D; Rocky Mountain Laboratory Research Technologies Section, Genomics Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Ricklefs S; Rocky Mountain Laboratory Research Technologies Section, Genomics Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Virtaneva K; Rocky Mountain Laboratory Research Technologies Section, Genomics Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Asghar M; Department of Medicine Solna, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden., Homann MV; Department of Medicine Solna, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden., Turner L; Department of Immunology and Microbiology, Centre for Medical Parasitology, Faculty of Health and Medical Sciences, University of Copenhagen, København N, Denmark.; Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Martins J; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal and ICVS/3B's -PT Government Associate Laboratory, Braga, Portugal., Allman EL; Department of Biochemistry and Molecular Biology, Huck Center for Malaria Research, The Pennsylvania State University, State College, PA, USA., N'Dri ME; Université de Paris, Institut Cochin, Paris, France., Winkler V; Institute of Global Health, Heidelberg University Hospital, Heidelberg, Germany., Llinás M; Department of Biochemistry and Molecular Biology, Huck Center for Malaria Research, The Pennsylvania State University, State College, PA, USA.; Department of Chemistry, The Pennsylvania State University, State College, PA, USA., Lavazec C; Université de Paris, Institut Cochin, Paris, France., Martens C; Rocky Mountain Laboratory Research Technologies Section, Genomics Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA., Färnert A; Department of Medicine Solna, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden., Kayentao K; Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Ongoiba A; Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Lavstsen T; Department of Immunology and Microbiology, Centre for Medical Parasitology, Faculty of Health and Medical Sciences, University of Copenhagen, København N, Denmark.; Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Osório NS; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal and ICVS/3B's -PT Government Associate Laboratory, Braga, Portugal., Otto TD; Institute of Infection, Immunity & Inflammation, MVLS, University of Glasgow, Glasgow, UK., Recker M; Centre for Mathematics & the Environment, University of Exeter, Penryn Campus, Penryn, UK., Traore B; Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Crompton PD; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Portugal S; Center for Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany. portugal@mpiib-berlin.mpg.de.; German Center for Infection Research (DZIF), Heidelberg, Heidelberg, Germany. portugal@mpiib-berlin.mpg.de.; Max Planck Institute for Infection Biology, Berlin, Germany. portugal@mpiib-berlin.mpg.de.

Publikováno v: Nature medicine [Nat Med] 2022 Oct; Vol. 28 (10), pp. 2216.

Reply to: Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass.

Autor: Thomson-Luque R; Centre of Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany., Votborg-Novél L; Centre of Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany.; Max Planck Institute for Infection Biology, Berlin, Germany., Osório NS; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal and ICVS/3B's - PT Government Associate Laboratory, Braga, Portugal., Portugal S; Centre of Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany. portugal@mpiib-berlin.mpg.de.; Max Planck Institute for Infection Biology, Berlin, Germany. portugal@mpiib-berlin.mpg.de.

Publikováno v: Nature communications [Nat Commun] 2022 Sep 23; Vol. 13 (1), pp. 5558. Date of Electronic Publication: 2022 Sep 23.