Direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer

Autor: Guinevere G. Connelly, Orville O. Kirkland, Seven Bohannon, Daniel C. Lim, Robert M. Wilson, Edward J. Richards, Dousabel M. Tay, Hyuk Jee, Riley D. Hellinger, Ngoc K. Hoang, Liang Hao, Arnav Chhabra, Carmen Martin-Alonso, Edward K.W. Tan, Angela N. Koehler, Michael B. Yaffe, Wendy B. London, Pui Y. Lee, Florian Krammer, Robert C. Bohannon, Sangeeta N. Bhatia, Hadley D. Sikes, Hojun Li

Publikováno v: Cell reports methods. 2(8)

Neutralizing antibody (NAb) titer is a key biomarker of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but point-of-care methods for assessing NAb titer are not widely available. Here, we present a lateral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c270b7451118583c4f310cf520c588
https://pubmed.ncbi.nlm.nih.gov/35942328

Single virus assay reveals membrane determinants and mechanistic features of Sendai virus binding

Autor: Dragan Vujovic, Robert J Rawle, Orville O Kirkland, Papa Freduah A. Anderson, Patricia A. Thibault, Nandini Seetharaman, Benhur Lee, Kristopher D. Azarm, Amy Lam

Sendai virus (SeV, formally murine respirovirus) is a membrane-enveloped, negative sense RNA virus in the Paramyxoviridae family, and is closely related to human parainfluenza viruses. SeV has long been utilized as a model paramyxovirus and has recen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6226f4ec92ee90da37dd15bb1de82081
https://doi.org/10.1101/2021.11.23.469711

Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis.

Autor: Maynard AG; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.; Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA., Pohl NK; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.; Harvard School of Public Health PhD Program, Boston, MA 02115, USA., Mueller AP; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA., Petrova B; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Wong AYL; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.; Harvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115, USA., Wang P; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Culhane AJ; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA., Brook JR; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA., Hirsch LM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Hoang N; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Kirkland O; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Braun T; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Ducamp S; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Fleming MD; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA., Li H; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Pediatrics, University of California, San Diego, CA 92093, USA., Kanarek N; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.

Publikováno v: Science advances [Sci Adv] 2024 Feb 02; Vol. 10 (5), pp. eadj9479. Date of Electronic Publication: 2024 Jan 31.