Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine

Autor: Daniel R. Dempsey, Derek A. Nichols, Matthew R. Battistini, Orville Pemberton, Santiago Rodriguez Ospina, Xiujun Zhang, Anne-Marie Carpenter, Brian G. O’Flynn, James W. Leahy, Ankush Kanwar, Eric M. Lewandowski, Yu Chen, David J. Merkler

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract Agmatine N-acetyltransferase (AgmNAT) catalyzes the formation of N-acetylagmatine from acetyl-CoA and agmatine. Herein, we provide evidence that Drosophila melanogaster AgmNAT (CG15766) catalyzes the formation of N-acetylagmatine using an or

Externí odkaz: https://doaj.org/article/b2083b0e3aaf4cd49387f1ef030550cb

Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis

Autor: Ayesha Khan, Orville Pemberton, Diana Panesso, Truc T. Tran, Rafael Rios, Paul J. Planet, Sara D. Siegel, Cesar A. Arias, Sandra Rincon, Danielle A. Garsin, Hung Ton-That, Jinnethe Reyes, Milya Davlieva, Lorena Diaz, Melissa R. Cruz, April H. Nguyen, Yousif Shamoo, Kavindra V. Singh, William R. Miller, Apurva Narechania, Mauricio Latorre

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 52
Repositorio U. El Bosque
Universidad El Bosque
instacron:Universidad El Bosque

Bacteria have developed several evolutionary strategies to protect their cell membranes (CMs) from the attack of antibiotics and antimicrobial peptides (AMPs) produced by the innate immune system, including remodeling of phospholipid content and loca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606aa1dc7abfe6461eecb381a3a01533
https://escholarship.org/uc/item/8j65h21n